group II introns
Evolution of group II introns
... of group II introns to the spliceosome are not well refined, and multiple scenarios are possible ...LECA, group II introns likely invaded the nuclear genome and proliferated as ...
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Diversity, mobility, and structural and functional evolution of group II introns carrying an unusual 3' extension
... cereus group sequences, respectively (data not ...B.th.I6-like introns, shows that both retrohoming and retrotranspo- sition of unusual group II introns in plasmid or chromo- somal loci ...
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Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis
... Although group II introns can and have been retar- geted by the method mentioned above, in which the closest match to the native recognition site in a se- quence to be targeted is identified, and the ...
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Origin and evolution of spliceosomal introns
... between Group II intron dynamics and the evolution (emergence) of ...of Group II introns certainly must not be under-appreciated, and we explicitly note in the revised manuscript: ...
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Using bioinformatic and phylogenetic approaches to classify transposable elements and understand their complex evolutionary histories
... If nucleotide or amino acid sequences can be aligned to form reasonably-sized blocks of homology, conventional phylogenetic methods can be applied towards inference of their evolutionary histories. Reconstruction of RT ...
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Genetic repair Bruce A Sullenger, Series EditorRibozyme mediated revision of RNA and DNA
... retrohoming Group II introns to insert into thera- peutically relevant targets ...addition, introns that successfully integrated into the targets were identified using the selection scheme and ...
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Did group II intron proliferation in an endosymbiont-bearing archaeon create eukaryotes?
... of group II introns in two species of archaea, Methanosarcina acetovorans and Methanosarcina mazei [7,8]; in both cases, group II introns have become established as the result of ...
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Homing endonucleases from mobile group I introns: discovery to genome engineering
... as group I introns, group II introns and ...surrounding introns and inteins to act as invasive DNA elements, while the splicing activity allows the endonuclease gene to invade a ...
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The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?
... mitochondrial group II introns inserted into the host genome sweep to fixation in the population via drift, and subsequently expand in num- ...'berserk introns' theory to work over a long ...
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Meeting Report for Mobile DNA 2010
... and group II introns illustrated both the continued activity of these elements in altering the human genome and the remark- able diversity of regulatory mechanisms of the various non-LTR ...
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Potential roles of microRNAs in regulating long intergenic noncoding RNAs
... potentials), the regions were further filtered by their distance to the nearest known gene, signal levels from RNA Polymerase II (RPolII) ChIP-seq data, and coding substitution frequency (CSF) scores. (3) ...
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Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss
... genome, genes are not identical. Some genes have unique characteristics (high expression in germline cells, co- expression with RT) that increase the frequency of mRNA reverse transcription compared with other genes ...
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Emergence and loss of spliceosomal twin introns
... extant introns in the orthologue gene (miscalled locus ASP- NIDRAFT_53020) by sequencing cDNA (GenBank MF612151) including the complete coding region encod- ing a peptide of 909 amino acids in ...
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Spliceosomal introns in Trichomonas vaginalis revisited
... 11 introns allowed us to classify them into two distinct types, named here types A and B, based on their sequence properties and splicing motifs ...8 introns and were closely related to the existing ...
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Original Article Effects of subchronic exposure to lead acetate and cadmium chloride on rat’s bone: Ca and Pi contents, bone density, and histopathological evaluation
... control group shows the bone trabeculas from distal of femur were more numerous (↑) (×50); B: The femoral bone trabecula were few, thin, and developed local fracture ( ↗ ) (×55); C: The surfaces of bone trabeculas ...
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Selection on Position of Nonsense Codons in Introns
... To test whether there is evidence that selection has acted to minimize the deleterious effects of failure to remove an intron from an mRNA by modifying the location of PTCs, we utilized data from seven model organisms: ...
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Exon definition as a potential negative force against intron losses in evolution
... and ii) the typical small size and narrow size distribution of exons in those same ...as introns loss results in fusion of exons and the formation of a new, long exon, so if intron loss rate is low, there ...
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Patterns of Y and X Chromosome DNA Sequence Divergence During the Felidae Radiation
... Zfx introns, character-based analysis reveal the precision with which each site change reflects mated time (in millions of years) that members within evolutionary ...
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Introns Regulate RNA and Protein Abundance in Yeast
... larger introns than nonribosomal i-genes (B on et ...longer introns provide more ‘‘real estate’’ for potential regulatory sequences al- though no such sequences have yet been ...of introns affect ...
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Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength
... We measured the kinetics of transcription and splicing recovery following release from drug-induced transcrip- tional arrest using a previously published protocol [37]. Briefly, control siRNA-treated cells and ...
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