Growth differentiation factor-15
The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis
... Figure 1. Serum Growth differentiation factor 15 (GDF15 ) levels in patients with various hematological malignancies. Serum concentrations of GDF15 were measured by ELISA in 14 normal subjects ...
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Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
... Growth differentiation factor-15 (GDF15), a TGF- β / bone morphogenetic protein (BMP) superfamily mem- ber, is a 40-kDa secretory propeptide that is cleaved in the endoplasmic reticulum to ...
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Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice
... Kook Hwan Kim 1 , Seong Hun Kim 2 , Dai Hoon Han 3 , Young Suk Jo 4 , Yong-ho Lee 4 & Myung-Shik Lee 1,4 Growth differentiation factor 15 (GDF15) is an endocrine hormone belonging to the TGFβ ...
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A meta-analysis of genome-wide association studies of growth differentiation Factor-15 concentration in blood
... Growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), is a stress response cytokine and a divergent member of the transforming growth ...
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Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells
... migration, growth and chemo-resistance of tumor cells in several solid tumors, including human prostate, pancreatic, colo- rectal carcinoma, and in hematologic malignancies, such as multiple myeloma, and the ...
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Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
... C. Growth differentiation factor‑15 (GDF‑15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary ...
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Pericardial fluid levels of growth differentiation factor 15 in patients with or without coronary artery disease: a prospective study
... Background: Growth differentiation factor 15 (GDF15) has already been reported as a novel efficient biomarker in patients with coronary artery diseases ...
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Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer
... on growth inhibi- tion and apoptosis of BGC-823 ...in growth differentiation factor-15 (GDF-15) was verified by qRT-PCR and Western ...
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Bovine Growth Differentiation Factor 15 (GDF-15) Elisa kit
... 2. PRINCIPLE OF THE ASSAY GDF-15 ELISA kit applies the competitive enzyme immunoassay technique utilizing an anti-GDF-15 antibody and an GDF-15-HRP conjugate. The assay sample and buffer are ...
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Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis
... In conclusion, serum GDF-15 levels were found to be significantly increased in patients with ulcerative colitis. These patients also had significantly lower levels of hemoglobin. Increases in GDF-15 may ...
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Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease
... Statistical analysis Continuous variables were presented as means ± SDs, while categorical variables were described as percent- ages. Comparisons between groups were performed by using unpaired Student’s t test for ...
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Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest
... Limitations Several limitations of our study should be noted. First and foremost, it was performed at a single center and involved a small number of patients, which limited the generalization of our observations. ...
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The interplay of growth differentiation factor 15 (GDF15) expression and M2 macrophages during prostate carcinogenesis
... epithelium-derived factor, has been shown to act directly on monocytes/macro- phages by inducing their migration and differentiation into M1-type cells ...
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Growth differentiation factor 15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study
... Statistical analysis The Wilcoxon rank-sum test or Student ’ s t -test were used to analyze differences in continuous variables between patients with and without PVD. Simple linear regression was used to test ...
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Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
... In conclusion, we are the first to demonstrate that leuko- cyte deficiency of GDF-15 improves atherosclerotic plaque stability by impairing macrophage migration and inducing collagen deposition. Our data not only ...
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Preoperative plasma growth differentiation factor 15 for prediction of acute kidney injury in patients undergoing cardiac surgery
... Conclusions In conclusion and taking into account the limitations of a monocentric study, but supporting findings from pre- vious work in patients undergoing CABG [8, 9], the present analysis shows that preoperative ...
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Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes
... Liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) are commonly induced by chronic hepatitis C virus (HCV) infection. We aimed to identify and characterize the involvement of previously screened cytokine GDF15 ...
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Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease
... Of note, our results demonstrated that CAD patients had high concentrations of GDF-15 and low levels of testosterone. Furthermore, the results of comparison means of GDF-15 across different testosterone ...
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Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo
... are a predictor of all-cause mortality in elderly individuals. 9,10 The mechanism linking the protein to mortality is not clear, but some evidence suggests that GDF-15 may promote muscle wasting perhaps providing ...
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The effect of red blood cell transfusion on plasma hepcidin and growth differentiation factor 15 in gastric cancer patients: a prospective study
... In our study, an increase in plasma hepcidin concentration after RBC transfusion was observed. This result confirms our hypothesis. To explore the reasons for this increase, plasma erythropoietin and IL-6 were analyzed. ...
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