GROWTH-FACTOR RECEPTOR
Epidermal Growth Factor Receptor PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
... depolymerizing factor family that is critical for actin ...epidermal growth factor receptor (EGFR)-phosphatidylinositide 3-kinase (PI3K) signaling pathway, which leads to virus-induced early ...
15
Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... Tamoxifen resistance has also been shown to emerge from a subpopulation in which epidermal growth factor receptor (EGFR) and/or Her2 mitogenic signaling is hyperactived. Transfection and activation ...
6
Redefining prognostic factors for breast cancer: YB 1 is a stronger predictor of relapse and disease specific survival than estrogen receptor or HER 2 across all tumor subtypes
... epidermal growth factor receptor (HER)-2 is a marker of poor prognosis in breast can- cer, following its initial report in 1987 by Slamon and cowork- ers ...this receptor such as trastuzumab ...
9
Vasculogenic mimicry is associated with trastuzumab resistance of HER2 positive breast cancer
... epidermal growth factor receptor (HER)-2 is called HER2-positive (HER2+) breast ...a receptor tyrosine kinase that has no specific ligands; the protein is activated when it forms a homodimer ...
18
Integration of endocrine therapy with targeted agents
... that growth factor receptor and downstream kinases often operate in conjunction with ER through bidirectional crosstalk to account for both de novo and acquired endocrine ...
5
Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
... epidermal growth factor receptor (EGFR). Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature over the past few years ...
8
ER and PR signaling nodes during mammary gland development
... estrogen receptor and progesterone receptor signaling ...Estrogen receptor (ER) and progesterone receptor (PR) can bind directly to DNA-specific sequences or indirectly by binding to other ...
12
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
... Tyrosine receptor kinases and PKA activate the Src/Ras/ Raf/MEK/ERK ...cyst growth in nonorthologous models and Pkd1 heterozygous mice (127, 131), and a phase II clinical trial is currently ongoing ...
11
PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients
... with tamoxifen resistance. In our primary analysis, we tested the clinical validity of these molecular alterations as single markers, analyzed as binary factor. Covariate adjusted Cox proportional hazard ...
10
HER2 therapy: Molecular mechanisms of trastuzumab resistance
... Growth factor receptor tyrosine kinases, such as HER2 and IGF-IR, activate the PI3K signaling ...trastuzumab-mediated growth arrest of HER2- overexpressing breast cancer ...
8
Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer
... (PIK3R1), receptor tyrosine kinases (RTKs) such as human epider- mal growth factor receptor (HER)2 (ERBB2) and fi bro- blast growth factor receptor (FGFR)1, the PI3K ...
12
New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
... Long years of basic and clinical research have resulted in a switch from this repetitious iatrogenic intoxication of patients and their tumors to more targeted antineo- plastic “snipers”, which eliminate tumor cell ...
11
Molecular biology of breast cancer metastasis Inflammatory breast cancer: clinical syndrome and molecular determinants
... estrogen receptor (ER) and progesterone receptor (PgR) expression has been corre- lated with a shorter disease-free survival time and overall poor clinical outcome of breast cancer patients, including those ...
7
Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
... the receptor for insulin (class II), for PDGF (Class III), for FGF (class IV), for VEGF (class V) and HGF (MET, Class VI) are strongly associated with oncological ...
12
Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response
... Molecular markers of response and survival can vary across breast cancer subtypes. Therefore, molecular sub- types need to be considered when evaluating associa- tions between tumor expression and clinical outcomes. In ...
13
Lack of transforming growth factor β signaling promotes collective cancer cell invasion through tumor stromal crosstalk
... Our results begin to pinpoint a mechanism responsi- ble for the clustered T b RII KO epithelial invasion versus the single cell or strand migration of TGF- b -competent epithelia. Tmeff1 is a crucial inhibitor of the ...
18
Fibroblast growth factor 2 orchestrates angiogenic networking in non GIST STS patients
... FGF2, PDGF-B and VEGFR-3 expression leads to acti- vation of several different intracellular pathways includ- ing PI3K, MEKK, SEK, PLCg and others. Further studies to investigate the relative involvement of these ...
8
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
... two receptor molecules into a ...the growth factor by FGFR2, recep- tor dimerization is stabilized and autophosphorylation is up- ...the receptor, and to recruit downstream effector proteins ...
12
CT Imaging Correlates of Genomic Expression for Oral Cavity Squamous Cell Carcinoma
... endothelial growth factor receptors and ligands), which relate to enhancement on the basis of other tumor types; and epidermal growth factor receptor, which may relate to proliferation ...
5
Pre eclampsia : predicting onset and poor outcome
... intrauterine growth restriction was established on the basis of a birth weight below the 10th weight for gestational age centile, using the gestation related optimal weight standard (GROW)(Gardosi,1992), with ...
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