Growth factor receptor
PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients
... epidermal growth factor receptor 2 (HER2), phosphatase and tensin homolog (PTEN), and insulin-like growth factor 1 receptor ...
10
The coexpression and prognostic significance of c-MET, fibroblast growth factor receptor 2, and human epidermal growth factor receptor 2 in resected gastric cancer: a retrospective study
... fibroblast growth factor receptor 2 (FGFR2), and human epidermal growth factor receptor 2 (HER2) in human GC and their clinical significance in clinical therapy were ...
11
The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... the receptor during transport. As a receptor involved in FGF signaling, Flg is found in the membrane fraction, as it is a membrane-associated protein (Meyers et ...
132
The autotaxin-lysophosphatidic acid–lysophosphatidic acid receptor cascade: proposal of a novel potential therapeutic target for treating glioblastoma multiforme
... Bevacizumab, a monoclonal antibody that recognizes VEGF, is currently clinically approved for GBM treat- ment. Unfortunately, although bevacizumab treatment prolongs progression-free survival in a subset of pa- tients, ...
9
In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features
... Epidermal growth factor receptor (EGFR) is an attractive therapeutic target for a number of human tumors including non-small cell lung cancer ...
51
Use of anlotinib in intra-abdominal desmoplastic small round cell tumors: a case report and literature review
... multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1–3, fibroblast growth factor receptor (FGFR) 1–4, ...
5
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
... Epidermal growth factor receptor; ER: Estrogen receptor; EZH2: Enhancer of zeste homolog 2; FAK: Focal adhesion kinase; FGFR: Fibroblast growth factor receptor; GGNBP2: ...
16
New developments in the treatment of HER2-positive breast cancer
... epidermal growth factor receptor 2 (HER2) by trastuzumab; (2) receptor cross talk, where cell surface receptor kinase such as insulin-like growth factor 1 receptor ...
12
Patient survival and tumor characteristics associated with CHEK2:p I157T – findings from the Breast Cancer Association Consortium
... BCAC Breast Cancer Association Consortium, ER estrogen receptor, PR progesterone receptor, Her2 human epidermal growth factor receptor 2, EGFR epidermal growth factor receptor, CK5/6 cyt[r] ...
15
Expression of amphiregulin predicts poor outcome in patients with pancreatic ductal adenocarcinoma
... malignancies in humans [4]. There is increasing recogni- tion that epidermal growth factor receptor variant III (EGFRvIII), the most common form of mutant EGFR, is an important target for cancer ...
8
Selective use of vandetanib in the treatment of thyroid cancer
... Rat sarcoma (RAS) genes encode proteins activating MAPK and PI3K pathways (Figure 1). RAS activation depends on epidermal growth factor receptor (EGFR), and is often overexpressed if mutated. RAS ...
12
NGF Induces Proliferation and Aggressiveness in Prostate Cancer Cells.
... androgen receptor and nerve growth factor receptor in prostate cancer cells: implications for a new. 725[r] ...
24
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
... Tyrosine receptor kinases and PKA activate the Src/Ras/ Raf/MEK/ERK ...cyst growth in nonorthologous models and Pkd1 heterozygous mice (127, 131), and a phase II clinical trial is currently ongoing ...
11
Synthesis, characterization and molecular docking studies of anilinoquinazoline derivatives
... H and 13 C Nuclear magnetic resonance and mass spectroscopic analysis. Compounds PR (1-6) were screened for cytotoxicity assays against various cell lines such as HCT116, K562, SKBR3 and EAC cell lines , trypan blue dye ...
9
ER and PR signaling nodes during mammary gland development
... its receptor (receptor activator of NF-κB) in the mammary epithelium is sufficient to induce side branching in virgin mammary Figure ...estrogen receptor (ER) alpha/ progesterone receptor ...
12
Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
... epidermal growth factor receptors (EGFRs) or ERBB receptors has attracted great attention in the literature ...epidermal growth factor receptor (HER)2/neu (c-erbB2), HER3 (c-erbB3) and ...
8
HER2 therapy: Molecular mechanisms of trastuzumab resistance
... Growth factor receptor tyrosine kinases, such as HER2 and IGF-IR, activate the PI3K signaling ...trastuzumab-mediated growth arrest of HER2- overexpressing breast cancer ...
8
<p>Targeting the MET-Signaling Pathway in Non-Small–Cell Lung Cancer: Evidence to Date</p>
... epidermal growth factor-receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) ...tropomyosin receptor kinase (NTRK) in all patients whose cancers express it (making it a marker for ...
16
6100.pdf
... EGFR(epidermal growth factor receptor) and the related HER-2 (human epidermal growth factor receptor 2) associated with breast cancer has allowed for the development of more ...
46
EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis
... epidermal growth factor receptor (EGFR), were found effective in combination with chemotherapy or as a single agent for the treatment of chemotherapy-resistant mCRC ...
9