growth plate chondrocytes
Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ – prostaglandin E2dependent proliferation of growth plate chondrocytes
... in growth plates as well as in cultured ...both growth plates and cultured chondrocytes expressed COX-1 and COX-2 mRNA (Figure ...rat growth plate tissue and in cultured rat ...level, ...
11
The Effect of Estradiol on the Growth Plate Chondrocytes of Limb and Spine from Postnatal Mice in vitro: The Role of Estrogen-Receptor and Estradiol Concentration
... on growth plate chondrocytes at postnatal stages in the present ...primary chondrocytes was validated in culture medium with low-concentration FBS in the CCK8 analysis and was shown to ...
10
Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes
... [15,16]. Growth plate chondrocytes have active telomerase [43], yet exhibit senescence at an earlier age relative to most somatic cells [23] undergoing only 3 to 5 rounds of mi- tosis before ...
8
Differential effects of insulin like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo
... physiological values by IGF-I and GH. In contrast, cell productivity, i.e., increases in cell volume, height, and matrix production per unit of time, did not reach normal values with either IGF-I or GH, and this ...
10
Effect of nitrogen-rich cell culture surfaces on type X collagen expression by bovine growth plate chondrocytes
... adulthood, growth of the long bone is centred in the cartilagenous growth plates, leading to an increase in bone length and epiphyseal ...mammalian growth plate can be divided into several ...
12
Convergent extension movements in growth plate chondrocytes require gpi anchored cell surface proteins
... resting chondrocytes appeared normal but proliferative chondrocytes failed to flatten or form columns ...mutant chondrocytes adjacent to discoid wild- type chondrocytes ...the growth ...
12
Calcium/calmodulin dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes
... of growth plate chondrocytes is regulated by CamkII ...on chondrocytes) that results in an inverse gradient of CamkII activity (green in ...proliferative chondrocytes that can be ...
12
Long non-coding RNA Gas5 regulates proliferation and apoptosis in HCS-2/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 regulation
... Previous studies have shown that the expression of Gas5 is negatively regulated by mTOR [19], which promotes cell proliferation. In the present study, Gas5 overexpres- sion down-regulated miR-21 levels and miR-21 ...
10
Enhancement of cartilage repair through the addition of growth plate chondrocytes in an immature skeleton animal model
... autogenic chondrocytes, allogenic chondrocytes, mesen- chymal stem cells (MSCs; most widely used; can be de- rived from bone marrow, blood, synovium, and synovial fluid), and human pluripotent stem cells ...
10
Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes
... proliferative chondrocytes grow by clonal expansion, cell division is biased against orientations that result in daughter cells aligned parallel to the column (Dodds, ...resting chondrocytes divided at ...
10
HIF1α is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development
... the growth plate of developing bones as a model system, we identify the transcription factor hypoxia-inducible factor 1 (HIF1) as a central component in a mechanism that underlies collagen hydroxylation ...
12
HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes
... profiles during the induction of the osteoblast phenotype in C2C12 cells; ii the exhibition by both genes of robust expression in osteoprogenitors, growth plate chondrocytes, and osteobl[r] ...
16
Leptin-deficient mice have altered three-dimensional growth plate histomorphometry
... in growth plates of obese ...Tibial growth plate chondrocytes of leptin-deficient mice exhibit disturbed 2D columnar structure with inhibited proliferation and extracellular matrix synthesis ...
5
JAWS coordinates chondrogenesis and synovial joint positioning
... embryonic growth plate, chondrocytes align in a pseudocolumnar arrangement along the longitudinal axis according to their differentiation status, which is reflected in the demarcation of four ...
6
Effects of interleukin 1 on syntheses of alkaline phosphatase, type X collagen, and 1,25 dihydroxyvitamin D3 receptor, and matrix calcification in rabbit chondrocyte cultures
... The effect of IL-1 on expression of the mineralization-related phenotype by chondrocytes was examined. In cultures of rabbit growth plate chondrocytes, IL-1 beta at 0.1 ng/ml caused 95% ...
9
Lin28a overexpression reveals the role of Erk signaling in articular cartilage development
... and growth plate ...articular chondrocytes and synovial cells, but not those of growth plate chondrocytes (Rountree et ...
6
Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice
... a growth plate with orderly columns of prolife- rating chondrocytes ...tibial growth plates exhibited disorderly co- lumnar arrays of chondrocytes as well as acellular regions in the ...
8
Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes
... stable. However, a substantial number of mRNAs in each sample set exhibited rapid turnover. We observed that the number of short-lived transcripts was higher in chondrocytes from OA tissue than in ...
10
Two mutations within a feline mucopolysaccharidosis type VI colony cause three different clinical phenotypes
... the growth plate, the major site responsible for bone ...bone growth typical of most of the MPS types is ...in chondrocytes indicates that they are closely implicated in this abnormal ...in ...
12
Differential gene expression associated with postnatal equine articular cartilage maturation
... the growth plate during endo- chondral ossification, though expression can still be detected in postnatal articular cartilage ...neonatal chondrocytes (Table ...
14