GTPase-activating Proteins
GTPase-Activating Proteins for Cdc42
... Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive ...of proteins called ...
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Specific Rab GTPase activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
... Rab GTPase- activating proteins (GAPs) that interfere with this ...domain–containing proteins, the identifi cation of specifi c Rab–Rab GAP pairs is not a trivial task (Zerial and McBride, ...
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Haas, Alexander (2008): Regulation of endocytosis and secretion by Rab GTPase activating proteins. Dissertation, LMU München: Fakultät für Biologie
... domain proteins, RabGAP-5 is a multi domain ...in proteins involved in signal ...several proteins that are linked to GTPases of both the Rab and the Rap ...
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Analysis of Rab GTPase-Activating Proteins Indicates that Rab1a/b and Rab43 Are Important for Herpes Simplex Virus 1 Secondary Envelopment
... envelope proteins accumulate in the ER, and virus assembly is less ...envelope proteins are incorporated into virions at the TGN or, interest- ingly, that secondary envelopment could occur at other post- ...
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Biochemical characterisation of rho/rac GTPases and their GTPase activating proteins in humans and Dictyostelium discoideum
... the GTPase activity and interactions with target proteins have been ...intrinsic GTPase activity of the protein and renders the GTPase resistant to acceleration by GAP although the interaction ...
240
Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS
... Arf1 GTPase activity [11]. Second, Ruk/ CIN85 can recruit variety of GTPase-activating proteins [[10,26,27] and this ...component proteins are rarely dedicated to one particular ...
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Drinking problems: Mechanisms of macropinosome formation and maturation.
... cytoskeletal proteins and inositol phospholipids have been identified, how they are spatially and temporally organized over the large distances involved in macropinocytic cup formation is poorly understood ...and ...
27
C elegans Rab GTPase activating protein TBC 2 promotes cell corpse degradation by regulating the small GTPase RAB 5
... small GTPase, the role of RAB5 as a molecular switch relies on it oscillating between inactive GDP-bound and active GTP-bound states, which is coordinated by guanine nucleotide exchange factors (GEFs) and ...
11
The Arf-GTPase-Activating Protein Gcs1p Is Essential for Sporulation and Regulates the Phospholipase D Spo14p
... SPO14, encoding the major Saccharomyces cerevisiae phospholipase D (PLD), is essential for sporulation and mediates synthesis of the new membrane that encompasses the haploid nuclei that arise through meiotic divisions. ...
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RPE phagocytic function declines in age related macular degeneration and is rescued by human umbilical tissue derived cells
... Rho GTPase effectors, PLD1 and PAK3, were upregulated by the treatment, suggesting that hUTC-secreted RTK ligands, such as GDNF, BDNF and HGF, and possibly other RTK ligands and factors, could enhance Rho ...
15
The Arf GTPase Activating Protein Family Is Exploited by Salmonella enterica Serovar Typhimurium To Invade Nonphagocytic Host Cells
... Arf GTPase-activating proteins (GAPs) can downregulate Arf signaling by stimulating GTP hydrolysis, but whether they do this during infection is ...Arf GTPase activation and ...
11
Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma
... Previous studies have indicated that IQGAP3 plays an important role in cell proliferation, adhesion, migration, and metastasis in various cancers [17, 18, 23, 24]. Further- more, IQGAP3 has been identified as a ...
14
Lrg1p Is a Rho1 GTPase-Activating Protein Required for Efficient Cell Fusion in Yeast
... non that is necessary for fertilization (see reviews of the cell cycle and transcriptional induction of genes of Wassarman et al. 2001; Talbot et al. 2003) and develop- required for conjugation (reviewed in Dohlman and ...
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Purification and functional characterization of brain and recombinant chimaerin, a p21rac GTPase activating protein
... separating proteins by SDS-PAGE followed by western ...renatured proteins were incubated with a solution containing [y^^P]GTP-bound p21s, and then laid on an agarose gel to limit diffusion of ...fusion ...
243
Lymphangioleiomyomatosis — a wolf in sheep’s clothing
... conserved GTPase-activating protein (GAP), and TSC1 encodes hamartin, which heterodimerizes with tuberin (49) and appears to be essential for its function (Figure ...
11
Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia
... No evidence of previously described CNS autoantibodies All reference sera were negative for anti-ARHGAP26 in a previously described dot-blot assay [30-32]. The index serum was, in addition, tested for anti-ARHGAP26 in ...
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Ras GTPase-Activating Protein Regulation of Actin Cytoskeleton and Hyphal Polarity in Aspergillus nidulans
... Ras proteins are the founding members of the “true” Ras protein subfamily ...Ras proteins have been intensively studied because its deregulation results in malignant cell transforma- ...Ras proteins ...
13
Poliovirus Proteins Induce Membrane Association of GTPase ADP-Ribosylation Factor
... membrane proteins and initiate membrane remodeling (46, ...the proteins that accel- erate replacement of bound GDP by GTP (44, 55, 62, ...poliovirus proteins but also RNA replication and assembly of ...
10
The Function of Rac Small GTPase and Associated Proteins in Rice Innate Immunity
... G- proteins are involved in a variety of signaling activities, including light reception, hormone signaling, and regulation of ion channels (Perfus-Barbeoch et ...
10
Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)
... The family of PI3K proteins mainly regulates cellular growth and cycle. Its activation is triggered by upstream receptor tyrosine kinase such as ErbB family receptor (including EGFR), platelet-derived growth ...
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