H19 gene
Dynamic readjustment of parental methylation patterns of the 5' flank of the mouse H19 gene during in vitro organogenesis
... the H19 gene, which is not only methylated in a parent of origin-specific manner, but also regulates the silencing of the maternal Igf2 and paternal H19 alleles, ...or H19 expression patterns ...
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H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury
... of H19, a developmentally regulated gene, in rat blood ...the H19 gene is associated with the differentiation process that takes place during development of many ...this, H19 was highly ...
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Original Article Long non-coding RNA H19 protects PC-12 cells from hydrogen peroxide-induced injury by targeting miR-155 in spinal cord injury
... The H19 gene produces lncRNA that is 2.3 kb long [10]. LncRNA H19 is highly expressed in extraembryonic tissues, embryo proper and most fetal tissues, but the expression was sig- nificantly reduced ...
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Original Article Long noncoding RNA H19 inhibits the growth and invasion of trophoblasts by inactivating Wnt/β-catenin signaling via downregulation of DDX3X
... lncRNA-H19 gene transcript is present in the placenta from the early developmental stage to the late developmental stage in mice. The main physiological role of lncRNA-H19 in mice is to limit ...
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H19, a marker of developmental transition, is reexpressed in human atherosclerotic plaques and is regulated by the insulin family of growth factors in cultured rabbit smooth muscle cells
... of H19 in liver cells ...and H19 during embryogenesis and fe- tal development (17, 38), their adjacent physical chromosomal location (39), and their opposed imprinting pattern (4, 40), it was proposed that ...
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H19 acts as a trans regulator of the imprinted gene network controlling growth in mice
... the H19 non-coding RNA. Targeted deletions of the H19 gene (H19 Δ13 and H19 Δ3 ) have lead to overgrowth phenotypes, which can be explained by a cis effect of the H19 locus on ...
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Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
... the H19 ICR protects its pater- nal methylation status against pre-implantation repro- gramming of the whole ...the H19 ICR was under control of the surrounding sequences somewhere within the ...
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Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
... regulating gene expression during cellular differentiation during embryonic develop- ment and throughout life ...) gene, coding a well-characterized growth factor active throughout embryogenesis and fetal ...
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Association of lncRNA H19 rs217727 polymorphism and cancer risk in the Chinese population: a meta-analysis
... LncRNA H19, as an imprinted gene, servers as an oncogene and was aberrantly increased in several cancers, and it might promote carcinogenesis via acting as competitive endogenous RNAs (ceRNA) or precursors ...
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Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls
... of H19 lncRNA. In 2012, Riaz et al. analysed mRNA expression of the gene H19 most likely to be closely located to SNP rs2107425 in a subset of 1,401 primary breast ...and H19 mRNA expression ...
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Functional polymorphisms of the lncRNA H19 promoter region contribute to the cancer risk and clinical outcomes in advanced colorectal cancer
... the H19 gene ...that H19 rs2107425 polymorphism had close relationships with radiation therapy response in breast cancer patients in the United States (n = 859) ...that H19 rs2107425 ...
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Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3
... (lncRNA) H19 gene is located on chromosome 11 in humans and is a maternally expressed imprinted gene that plays a vital role in mammalian development [10, ...Although H19 has been intensively ...
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H19 controls reactivation of the imprinted gene network during muscle regeneration
... of H19, which can be rescued by the H19 ...of H19 acting as a tumor suppressor (Yoshimizu et ...the H19 −/+ ;Tg strongly suggests that the H19 gene is involved in the control of ...
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Myod and H19 Igf2 locus interactions are required for diaphragm formation in the mouse
... imprinted H19-Igf2 ...the H19 promoter, leading to increased H19 expression in the presence of ...non-coding H19 RNA represses Igf2 expression in ...
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Regulation of Imprinted Genes in the brain by the ATRX Chromatin Remodeling Protein
... the H19/Igf2 domain(Biniszkiewicz et ...the H19/Igf2 DMRs in the mouse ...the H19 ICR, we detected approximately 50% methylated alleles in both control and ATRX-null samples, indicating DNA ...
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DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
... Despite being a classically imprinted region, with clear-cut patterns of allele-specific gene expression, there is evidence of considerable epigenetic heterogeneity at the Igf2/H19 locus. Population studies ...
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The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy
... that H19 binds and inhibits S-adenosylhomocysteine hydrolase (SAHH), which con- sequently decreases DNMT3B-mediated methylation ...which H19 regu- lates Beclin1 expression, we examined methylation in the ...
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Original Article Upregulated lncRNA H19 promotes non-small cell lung cancer cell proliferation through miR-138/PDK1 axis
... LncRNA H19, encoded by an imprinted gene, was firstly found in the studies of embryonic development, and its functions in cancer have also attracted more and more attention ...lncRNA H19 has been ...
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Original Article Regulation and mechanisms of lncRNA H19 in COPD
... lncRNA H19 in COPD rats improved lung tissue struc- ture, downregulated secretion of inflammatory factors IL-6, IL-8, and TNF-α, upregulated SOD activity, and inhibited ROS generation, suggest- ing that lncRNA ...
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CTCF modulates allele specific sub TAD organization and imprinted gene activity at the mouse Dlk1 Dio3 and Igf2 H19 domains
... CTCF binding at the Meg3 DMR is required for allelic sub-TAD structuration and for correct imprinted activation of Dlk1 To confirm if CTCF binding to the maternal Meg3 DMR is essential for the structure of the maternal ...
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