H3K4 Methylation
Impaired removal of H3K4 methylation affects cell fate determination and gene transcription
... RBR-2 controls the enhancer signature of the lin-11 locus As ChIP-seq analysis of the rbr-2(tm3141) allele identified increased levels of H3K4me3 in regions upstream the TSSs (cluster 3 and 6), where distal enhancer ...
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Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers
... In the present study, we aimed to extend the under- standing of the molecular mechanisms of Pax6-mediated gene activation and repression [45] by identifying chro- matin remodeling activities associated with Pax6. Using ...
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Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy
... in H3K4 me3 redistribution in monocyte-derived dendritic cells [31, ...both H3K4 me3 enrichment and miRNA expression, and affects TNF-α production [31, ...increased H3K4 me3 in podo- ...of ...
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<p>Effect of <em>SMYD3</em> on biological behavior and H3K4 methylation in bladder cancer</p>
... lysine methylation, a group of proteins which contains the evolutionarily con- served Suppressor of variegation, Enhancer of Zeste and Trithorax (SET) domain are ...through methylation of histone 3 lysine-4 ...
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Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes
... Thus, we propose that the decrease in Kcnip2 transcript expression is a direct result of PTIP deletion and the inability of PTIP– mice to maintain a KMT2 complex and H3K4me3 marks at the[r] ...
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Histone H3 lysine K4 methylation and its role in learning and memory
... that H3K4 methylation is involved in both ...this H3K4 demethylase ...dysregulated H3K4 methylation during development and in the developed ...
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Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae
... ABSTRACT Histone post-translational modifications (PTMs) alter chromatin structure by promoting the interaction of chromatin- modifying complexes with nucleosomes. The majority of chromatin-modifying complexes contain ...
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Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
... promote H3K4 methylation and gene activa- tion (40, 41), we determined the level of H3R2SDM and found that it was significantly decreased after PRMT5 knockdown or PJ-68 treat- ment in K562 cells (Figure 9J) ...
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c Myb binds MLL through menin in human leukemia cells and is an important driver of MLL associated leukemogenesis
... MLL-mediated methylation of histone H3 at lysine 4 ...in H3K4 methylation, an unexpected decrease in HOXA9 and MEIS1 gene expression, and decreased MLL and menin occupancy in the HOXA9 gene ...
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KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance
... the methylation level of H3K4 decreased significantly in drug-resistant ...of H3K4 demethylases, JIB-04, restored the methylation of H3K4 and blocked the co-localization of XRCC1 and ...
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Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme
... of H3K4 methylation at target genes and inhibit the expression of tumor suppressor ...aberrant H3K4 trimethylation at enhancers leading to their conversion to promoters and the expression of ...
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The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae
... that methylation of two histone H3 lysines, H3K4 and H3K79, has a important role during meiotic DSB formation (Sollier et ...histone H3K4 methylation is a critical determinant of efficient DSB ...
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Nutritional Control of Epigenetic Processes in Yeast and Human Cells
... instance, H3K4 methylation in humans is placed by human SET-domain proteins and is enriched at transcriptionally active loci (Ruthenburg et ...H3K9 methylation is enriched in heterochromatin (Barski ...
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Normal transcription of cellulolytic enzyme genes relies on the balance between the methylation of H3K36 and H3K4 in Penicillium oxalicum
... histone methylation in yeast has revealed that H3K4me2 and H3K4me3 predominantly accumulate in transcriptionally active genes ...that H3K4 methylation shows specific enrichment patterns among ...in ...
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dSet1 Is the Main H3K4 Di- and Tri-Methyltransferase Throughout Drosophila Development
... Set1 H3K4 histone methyltransferase ...general H3K4 di- and trimethyl HMT in Drosophila. Levels of H3K4 di- and trimethylation are significantly reduced in dSet1 mutants during late larval and ...
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DNA Replication Origin Function Is Promoted by H3K4 Di-methylation in Saccharomyces cerevisiae
... that H3K4 di-methylation near origins recruits another chromatin modifier such as a ...binding H3K4 methylation (Sims et ...tri-methylated H3K4 to facilitate SAGA recruitment to some ...
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Regeneration after acute kidney injury requires PTIP-mediated epigenetic modifications
... histone H3K4 methyl- transferases that mark enhancers during development and cell lineage specification ...Mll-mediated H3K4 methyla- tion are Ash2, Wdr5, Rppb5 (30), and PTIP (17, ...imprint H3K4 ...
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The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation
... Several subunits of Set1C have been knocked down or out. In the Ash2 scaffold, knockdown of Wdr5 in ESCs resulted in reduced self-renewal, increased differentiation and global loss of H3K4me3 (Ang et al., 2011). However, ...
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Aberrant histone modification in CD19<sup>+</sup> B cells of the patients with chronic lymphocytic leukemia
... H3K9 methylation in patients with CLL were significantly increased compared with controls ...histone H3K4 methylation between the two ...histone methylation, histone acetylation, SIRT1, EZH2, ...
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The role of H3K4 methyltransferases in Drosophila memory
... Current literature suggests that post transcriptional processing of mRNA is important for normal memory function. For example, selective downregulation of alternatively spliced transcripts reduces stress enhanced memory ...
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