H5N1 influenza
An Anti-H5N1 Influenza Virus FcDART Antibody Is a Highly Efficacious Therapeutic Agent and Prophylactic against H5N1 Influenza Virus Infection
... pathogenic H5N1 avian influenza viruses are associated with severe disease in humans and continue to be a pandemic ...drifted H5N1 influenza viruses, we developed two neutralizing monoclonal ...
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Persistent Host Markers in Pandemic and H5N1 Influenza Viruses
... pandemic influenza virus isolates we surveyed (see Table A1) and are also enriched in the population of human H5N1 isolates (Table ...avian influenza virus like H5N1 into a virus that is ...
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A model to control the epidemic of H5N1 influenza at the source
... of influenza A ...pathogenic H5N1 strains due to their unique immune system, or if they are previously exposed to other H5 ...pathogenic H5N1 strains can revert or be selected to lowly pathogenic ...
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Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients
... Therefore, H5N1 viruses may acquire HA mutations that enable binding to both types of sialylglycans to effectively increase their binding affinity for human airway ...mutant H5N1 viruses with binding ...
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Improving global influenza surveillance: trends of A(H5N1) virus in Africa and Asia
... 97-like H5N1 influenza virus ...exotic H5N1 viruses isolated from poultry seized at a port of entry into Viet Nam ...avian influenza A (H5N1) viruses circulating in ...potential ...
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Characterization of a Highly Pathogenic H5N1 Avian Influenza A Virus Isolated from Duck Meat
... Kong H5N1 viruses because at least four of the internal genes are different from all previously characterized ...several influenza viral genes have been associated with virulence and host specificity, the ...
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Protective Memory Responses Are Modulated by Priming Events prior to Challenge
... pathogenic H5N1 avian influenza A viruses in the last decade have legitimized fears of a long-predicted ...virulent, H5N1 influenza A virus in the C57BL/6 mouse ...modified H5N1 virus ...
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Molecular Evolution of H6 Influenza Viruses from Poultry in Southeastern China: Prevalence of H6N1 Influenza Viruses Possessing Seven A/Hong Kong/156/97 (H5N1)-Like Genes in Poultry
... H6N1 influenza viruses was calculated to determine the rate of evolution of the viruses (Table ...H6N1 influenza viruses isolated in 2000 (group II) had a lower rate of nonsynonymous substitutions than did ...
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Therapeutic Trial of an Endothelin Receptor Agonist for the Highly Pathogenic Avian Influenza A/H5N1 Virus Infection in Chicks
... The A/H5N1 virus attaches to receptors on the cell surface, enters the cytoplasm by endocytosis, replicates using host enzymes and nucleotides, and a huge number of virions are subsequently produced by the host ...
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Sensitivity of Influenza Rapid Diagnostic Tests to H5N1 and 2009 Pandemic H1N1 Viruses
... the more recent isolates, with some exceptions. The differ- ence in clade or host did not account for this temporal tendency (compare the results for virus strains categorized as clade 1 in Tables 4 and 5). The ...
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A single dose of DNA vaccine based on conserved H5N1 subtype proteins provides protection against lethal H5N1 challenge in mice pre exposed to H1N1 influenza virus
... (H1N1) influenza virus six weeks ...or H5N1 influenza ...and H5N1 influenza viruses, ...against H5N1 virus, as proved by the HI ...lethal H5N1 chal- ...
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Use of Highly Pathogenic Avian Influenza A(H5N1) Gain Of Function Studies for Molecular Based Surveillance and Pandemic Preparedness
... HPAI H5N1 and other zoonotic influenza viruses evolve and how these mechanisms influence host receptor specificity, antigenic variation, replication, pathogenesis, drug susceptibility, and transmission ...
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Rapid Detection of H5N1 Subtype Influenza Viruses by Antigen Capture Enzyme-Linked Immunosorbent Assay Using H5- and N1-Specific Monoclonal Antibodies
... avian H5N1 influenza strains (clade ...four influenza B virus strains were isolated from human clinical samples by the Department of Pathology, Singapore General ...(2). H5N1 subtype viruses ...
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H5N1-SeroDetect EIA and Rapid Test: a Novel Differential Diagnostic Assay for Serodiagnosis of H5N1 Infections and Surveillance
... Therefore, H5N1 virus is detected in indi- viduals mainly during the period of acute ...human H5N1 influenza cases is likely underre- ported, missing nonsymptomatic H5N1 virus exposure cases ...
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Antigenic Drift in H5N1 Avian Influenza Virus in Poultry Is Driven by Mutations in Major Antigenic Sites of the Hemagglutinin Molecule Analogous to Those for Human Influenza Virus
... avian influenza virus has been endemic in poultry in Egypt since 2008, notwith- standing the implementation of mass vaccination and culling of infected ...avian influenza viruses is less well documented and ...
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Pathogenesis of Avian Influenza A (H5N1) Viruses in Ferrets
... human H5N1 cases, multiorgan dysfunction was associated with severe disease ...in H5N1 cases occurred late in the course of hos- pitalization after extensive periods of mechanical ...of H5N1 ...
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White-Tailed Sea Eagle (Haliaeetus Albicilla) Die-Off due to Infection with Highly Pathogenic Influenza Virus, Subtype H5N8, in Germany
... HPAIV H5N1 epidemic among wild birds in the same area in 2006, all sea eagles found dead (n=19) in the center of the outbreak, the Isle of Rügen (Mecklenburg Western- Pomerania), had always tested negative for AIV ...
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Single-Dose Vaccination of a Recombinant Parainfluenza Virus 5 Expressing NP from H5N1 Virus Provides Broad Immunity against Influenza A Viruses
... from H5N1 HPAI virus between SH and HN in PIV5 (ZL46; PIV5-H5- SH/HN) resulted in better protection against H5N1 HPAI virus challenge than insertions at the junctions of NP and V/P, V/P and M, or HN and L ...
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The Homologous Tripartite Viral RNA Polymerase of A/Swine/Korea/CT1204/2009(H1N2) Influenza Virus Synergistically Drives Efficient Replication and Promotes Respiratory Droplet Transmission in Ferrets
... The viral polymerase can mediate adaptation of influenza vi- ruses in a new host (35). The internal gene segments of CT-Sw/ 1204 and Sw/1130 have notable amino acid differences, which are likely responsible for ...
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Knowledge and attitude of poultry farmers towards biosecurity against zoonotic avian influenza H5N1 in Kaduna state, Nigeria
... Highly pathogenic and devastating as bird flu is, it is gratifying to note that the disease is preventable and can be controlled and contained. According to FAO (2008), the HPAI, like any disease that spreads primarily ...
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