haemophilia A / B
Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients
... Results: IB1001 PK non- inferiority to comparator rFIX was demonstrated through ratio of AUC 0-∞ in 32 subjects. IB1001 was well tolerated in all 76 treated sub- jects; the most common adverse drug reaction was headache ...
9
Haemophilia B in Five Nigerian Siblings
... Discussion: The peculiarity in these cases is the large number of affected individuals in one family. This is made more remarkable by the fact that haemophilia B (HB) is extremely rare in Nigeria. The ...
7
Investigated the hospital utilization and medical resource usage of haemophilia A and B in Taiwan: 2001 2010
... (hemophilia B, ...with haemophilia has significantly increased, largely because of the advances in medical care, the introduction and accessibility of factor replace- ment therapies, as well as improvements ...
8
HAEMOPHILIA: AN OVERVIEW
... of haemophilia, haemophilia A due to not enough clotting factor VIII and haemophilia B due to not enough clotting factor ...while haemophilia B affects about 1 in 40,000, males ...
10
Issues in pediatric haemophilia care
... in haemophilia currently are for haemophilia B, where intravenous infusion of an adeno-associated viral (AAV) vector encoding factor IX (FIX) under the control of a liver-restricted promoter has ...
5
Studies of HIV and HCV co-infection in the context of haemophilia
... El (31kD) and E2 (70kD) are the two envelope glycoproteins o f HCV. They are both type I transmembrane proteins with C-terminal domains that are probably important for membrane anchoring. Inefficient cleavage at the ...
284
Effect of progressive exercise program on the bleeding frequency in haemophilic patients
... with haemophilia were assigned into two equal groups; group A was the study group and consisted of 15 haemophilic patients (type A and B) with mild and moderate severity received their medical treatment and ...
6
Clinical Profile of Haemophilia In Children in A Tertiary Care Hospital
... of haemophilia were ...were haemophilia A and 10 (20%) cases were Haemophilia ...the Haemophilia A, ...the Haemophilia B, 40% cases had mild, 50% cases had moderate and 10% cases ...
7
Modelling gene therapy for haemophilia
... In theory, gene therapy offers the potential o f a life-long cure for even severe haemophiliacs (see review, Brownlee, 1995). By introducing a functional copy o f the clotting factor gene into a somatic cell of a ...
269
Treatment of Haemophilia A by Replacement Therapy using Factor VIII Inhibitors
... This mechanism is indicated by various studies that FVIII is actually responsible for the activation of immune response. As we know that FVIII is mainly T helper cell-mediated and always present on the antigen presenting ...
7
A STUDY OF HAEMOPHILIA IN MAHARASHTRA
... of haemophilia A to haemophilia B patients was ...severe haemophilia A patients were under 20 years of ...severe haemophilia A patients above 20 ...the haemophilia clinics, and ...
15
Epidemiology of Haemophilia in Greece: an overview
... Demogtaphic data of the Greek haemophiha A and B population for the penod 1972-1993 were analyzed Pievalence at buth includmg known not-registeied patients was calculated at 23 l pei 100[r] ...
6
Inhibitor development in non-severe haemophilia across Europe
... non-severe haemophilia A, 14 (36%) of inhibitors were observed in patients with moderate haemophilia (FVIII activity 1-5%) and 25 (64%) in patients with mild haemophilia (FVIII activity ...mild ...
17
Prevention of lives affected by haemophilia : a mixed methods study of the views of adults with haemophilia and their families towards genetic screening
... Tim was 51 years old at the time of his interview, and was diagnosed with hemophilia A in the early 1970s when he was three years old. Tim described the negative reaction of his family to the diagnosis, in particular the ...
19
European principles of inhibitor management in patients with haemophilia
... (European Haemophilia Consortium, Brussels, Belgium); ...(Portuguese Haemophilia Association, Lisbon, Portugal); ...(Serbian Haemophilia Society, Belgrade, Serbia); ...Haematology, Haemophilia ...
6
The cost of severe haemophilia in Europe: the CHESS study
... of haemophilia A patients relative to that of haemo- philia B in the CHESS cohort (approximately ...between haemophilia A and B is a topic of ongoing research; current evidence suggests that ...
8
Complications of haemophilia therapy
... Fresh or serum stored from 1979 from patients who had received any blood product therapy was tested for antibody to HCV by second-generation enzyme immunoassay, EIA, (Ortho Diagnostics, Amersham, England). RIBA-2 was ...
201
Clinico-Hematological Profile and Iron Studies in Haemophilia Patients in Government Royapettah Hospital
... The dose calculation for factor IX is different from that of Factor VIII as the intravascular recovery of factor IX is only 50%. This is probably due to the binding of Factor IX to collagen type IV in the vessel wall. ...
131
Haemophilia A: health and economic burden of a rare disease in Portugal
... The development of inhibitors results in a great im- pact to the economic burden of the disease. Our data suggests that a patient with inhibitors costs 7.6 times more than a patient without inhibitors. This can be ex- ...
11
Blood borne virus infection and immune modulation in boys with haemophilia A
... with haemophilia A and to treat them with only one factor VIII ...hepatitis B surface ...hepatitis B and non A non B hepatitis by monitoring liver function ...of haemophilia (Schimpf et ...
403