HCC cells
Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells
... cancer cells such as growth, proliferation, motility, metabolism and ...in HCC cells. As the substrate stiffness increased, HCC cells exhibited high proportion of cells with ...
11
A20 inhibits the motility of HCC cells induced by TNF-α
... in HCC tissues probably due to the inflammatory environment of HCC ...in HCC with metastasis is decreased compared to that in HCC without metastasis ...the HCC cells of MVI ...
13
2 Ethoxystypandrone, a novel small molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells
... HepG2/STAT3 cells were HepG2 cells stably transfected with a STAT3-responsive firefly luciferase reporter plas- ...HepG2/STAT3 cells (2 × 10 4 per well) were seeded into 96-well cell culture ...
13
Original Article Knockdown of UACA inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells
... To further validate the effect of hypoxia on UACA, we treated UACA-silencing or control HCC cells with CoCl 2 , a reagent which mimics a hypoxic environment. We observed that the expression of UACA was ...
10
<p>Long Noncoding RNA NEAT1 Promotes Cell Proliferation And Invasion And Suppresses Apoptosis In Hepatocellular Carcinoma By Regulating miRNA-22-3p/akt2 In Vitro And In Vivo</p>
... of HCC patients were collected and the correlations with NEAT1 expression were ...both HCC tissues and cell ...in HCC cells, which was opposite to the effect of NEAT1 ...promoted HCC ...
14
Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways
... in HCC tissues. In this study, the role of Cx32 in HCC metastasis and proliferation was ...in HCC tissues was significantly associated with increased vascular invasion, increased tumor size, and poor ...
18
<p>ARQ-197 enhances the antitumor effect of sorafenib in hepatocellular carcinoma cells via decelerating its intracellular clearance</p>
... Materials and methods: The antitumor effects of sorafenib or ARQ-197, an antagonist of c-MET (tyrosine-protein kinase Met or hepatocyte growth factor receptor), were examined by MTT or in murine tumor model. The effect ...
12
Original Article LncRNA GAS6-AS2 facilitates tumor growth and metastasis of hepatocellular carcinoma by activating the PI3K/AKT/FoxO3a signaling pathway
... in HCC tissues and ...in HCC tissues and ...on HCC cells. OTUB1, a target of miR-493-5p, was up-regulated in HCC cells and its expression was modulated by ...of HCC ...
13
miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1
... promotes HCC metastasis and pre- sents a novel mechanism of miRNA-mediated FOXO1 ...promoted HCC cell migration and ...in HCC cells transfected with miR-135a mimic, while miR-135a inhibition ...
7
MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10
... that HCC cell migration and proliferation is promoted by miR-18a through targeting of the KLF4 ...inducing HCC cell migra- tion and proliferation, miR-18a also inhibited apoptosis and initiated cell cycle ...
16
GIT1 is a novel prognostic biomarker and facilitates tumor progression via activating ERK/MMP9 signaling in hepatocellular carcinoma
... MHCC-97H cells that were sus- pended in 500 μ L serum-free DMEM were added into the upper chamber and DMEM medium with 10% fetal bovine serum was added into the lower ...the HCC cells on the inner ...
12
Metformin exhibits the anti-proliferation and anti-invasion effects in hepatocellular carcinoma cells after insufficient radiofrequency ablation
... Metformin exert a direct effect on cancer cells par- tially through the activation of AMPK. Furthermore, the mTOR/AMPK pathway is the main mechanism of action of metformin [25]. The mTOR pathway plays a major role ...
8
Microvascular invasion in hepatocellular carcinoma overexpression promotes cell proliferation and inhibits cell apoptosis of hepatocellular carcinoma via inhibiting miR-199a expression
... which HCC cells were supplemented with miR-199a inhibitor, the downregula- tion of MVIH-induced decrease in cell viability and increase in cell apoptosis were ...
8
MicroRNA-98 acts as a tumor suppressor in hepatocellular carcinoma via targeting SALL4
... in HCC still remains ...in HCC tissues compared to matched adjacent normal tissues ...of HCC cells. Besides, SALL4, upregulated in HCC tissues compared to the matched ANTs, was ...
15
<p>UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma</p>
... y, HCC cells were seeded in 6-well plates the day before ...to HCC cells with normal culture medium and 5 μ g/mL Polybrene (Sigma-Aldrich, ...transduced cells were collected for ...
12
Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition
... in HCC, whose overexpression is correlated with the poor prognosis of HCC ...MHCC97-H cells after CD44 inhibition, rather than Twist1, ZEB2 and FOXC2, indicating that CD44 knockdown may induce the ...
10
Long noncoding RNA ZNFX1-AS1 suppresses growth of hepatocellular carcinoma cells by regulating the methylation of miR-9
... in HCC cells. To further confirm whether ZNFX1-AS1 regulated HCC growth through miR-9, we examined the methylation of miR-9 in HepG2 and SNU449 cells, ...in HCC progression by ...
10
High USP22 expression indicates poor prognosis in hepatocellular carcinoma
... of HCC patients ...in HCC remain ...in HCC cell lines and cancer ...with HCC differentiation ...in HCC cells, USP22-specific siRNA was transfected into HepG2 ...HepG2 ...
14
ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling
... hepatoma cells. EGFR is the most important RTK in cancer cells, and activated EGFR promotes tumor growth in numerous cancer ...hepatoma cells. The hyperactivation of c-MET is frequently observed in ...
13
Original Article Screening candidate metastasis-associated genes in three-dimensional HCC spheroids with different metastasis potential
... high-metastatic HCC spheroid were apparently more than those in the low-meta- static spheroid, indicating that the highly meta- static spheroid secretes more matrix proteins and there are more interactions between ...
9