HDL function
Reduced HDL function in children and young adults with type 1 diabetes
... of HDL function per particle, analogous to measures of enzyme specific activ- ...study, HDL function per particle distinguished disease from healthy states better than the total level of ...
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The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender
... and Hdl-c) of 4205 people (3139 women, 1066 men) were examined ...and Hdl dependent paraoxonase-1 (PON1) and arylesterase (ARE) ...and HDL-C levels significantly higher compared to ...and ...
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Emerging therapeutic strategies to enhance HDL function
... of HDL-cholesterol in plasma results in a 2-3% decrease in CVD risk ...this HDL protective effect is the reverse cholesterol transport ...of HDL biology has not achieved a comparable success in the ...
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PON dering differences in HDL function in coronary artery disease
... mechanisms. HDL binding to SR-BI via apoA-I causes cholesterol efflux (orange circles) that is sensed by SR- BI, leading to PDZK1-dependent activation of Src family kinase(s), PI3K, and Akt, which phosphorylates ...
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Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
... with HDL isolated according to optimised proto- col at 10 ...with HDL overnight prior to stimulation with 20 ng/mL murine tumour necro- sis factor alpha (TNF-α) (PeproTech, 315-01A) for 8 ...
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Molecular regulation of HDL metabolism and function: implications for novel therapies
... disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol ...of HDL metabolism, macrophage cholesterol efflux, and HDL function will ...
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The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk
... of HDL are associated with disturbed HDL ...between HDL oxidation and ABCA1- dependent cholesterol efflux was observed by Zeng et ...following HDL oxidation ...changes HDL proteome ...
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Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial
... comprising HDL, and the list continues to ...numerous HDL proteins now appear to be involved in other biological functions such as the acute phase response [6] and inflammation ...other HDL ...
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The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation
... tory function of HDL ...of HDL in T2DM determined as HDL-mediated inhibition of LDL-induced chemotaxis of macrophages towards endothelial cell- conditioned ...of HDL with SAA was ...
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Effects of urban fine particulate matter and ozone on HDL functionality
... and HDL function in our study could be due to increased PM-induced arterial ...proinflammatory HDL, which can induce vaso- constriction and impaired acetylcholine-mediated relax- ation in mouse ...
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Raising HDL cholesterol in women
... raising HDL-C levels may have particular significance during the transition to ...discusses HDL-C-raising therapies and the role of HDL in the primary prevention of CHD in ...raising HDL-C, ...
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Associations between non-traditional lipid measures and risk for type 2 diabetes mellitus in a Chinese community population: a cross-sectional study
... Methods: We conducted a community-based, cross-sectional study of 9 078 participants aged 18 years or older (4 768 men and 4 310 women) who lived in the Jidong community, Tangshan, China. The adjusted odds ratios for ...
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Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults
... Information on demographic characteristics and risk factors was collected using clinical files. Body mass index was calculated by dividing weight (in kilograms) by the square of the height (in meters). We measured blood ...
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HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium
... Retinol binding protein (RBP) is another member of the Lipocalin family and transports retinol in plasma. Interestingly, apo-RBP is pro-apoptotic, whereas holo- RBP is anti-apoptotic [49]. We did not identify any pro- ...
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Plasma Lipid Profile and Uric Acid in High Fat Fed Female Rats Treated with Oral Contraceptive
... The result showed that high dose of Combined Oral contraceptive (HCOC) treatment led to a significant increase in total cholesterol when compared with vehicle group [37,38]. A number of researchers had showed that ...
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SELDI-TOF mass spectrometry of High-Density Lipoprotein
... the HDL consumes a minimum of time compared to the classic preparation techniques for lipid preparation ...the HDL associated proteins SELDI-TOF MS is much less labour intensive and much lower in sample ...
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Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis
... Previous studies had demonstrated the correlation be- tween dyslipidemia and liver disease. Obesity or dyslipid- emia is one of the primary risk factors of NAFLD [13]. Many clinical trials showed that statin, a ...
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Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A I in healthy men
... TG-enriched HDL? A number of hypotheses can be put forth to explain the increased catabolism of apo A-I on TG-enriched ...on HDL that had been whole-labeled and HDL that had been labeled by exchange ...
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HDL associated estradiol stimulates endothelial NO synthase and vasodilation in an SR BI–dependent manner
... with HDL was responsible for the stimulation of ...mice). HDL isolated from these mice stimulated eNOS nearly as well as HDL isolated from intact female mice (Figure ...when HDL isolated from ...
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A study of the influence of lipid profile in diabetic patients on the incidence of cerebrovascular events
... Background: The relationship between elevated serum lipids and atherosclerosis is well established. Recent studies have demonstrated not only that the serum lipid concentration but also the distribution of TG and ...
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