HDL-mediated cholesterol efflux
The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity
... with HDL-C level ...circulating HDL-C ...in HDL-C concentration ...and HDL-C, however, it is still unclear whether ANGPTL8 could affect HDL ...above, HDL-mediated ...
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Defective regulation of phosphatidylcholine specific phospholipases C and D in a kindred with Tangier disease Evidence for the involvement of phosphatidylcholine breakdown in HDL mediated cholesterol efflux mechanisms
... in cholesterol efflux ...the HDL deficiency nor the reduced cholesterol efflux, nor the cholesterol ester deposition, are per se atherogenic, and that additional factors are ...
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SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3
... LCAT- mediated cholesterol esterification [5], so it is possible that the increase in CE induced by ABCG1 in our study might be attributable to the active LCAT, which is retained in the HDL3 ...cellular ...
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Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein
... Because HDL plays an important role in RCT via the hepatobiliary route and contains the majority of circulat- ing lipoprotein cholesterol in mice, we considered HDL a likely candidate to directly ...
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A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA I
... low HDL and are associated with premature atherosclerosis (12, ...and cholesterol efflux to extracellular apoA-I and forms nascent HDL (14), which absorbs further lipids as it matures in the ...
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Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients
... that HDL compo- sitions are key determinants for the atheroprotective functions of ...tute HDL containing apoA-I restores endothelial cell function in hypercholesterolemia men [14], improves ...
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Regulation and mechanisms of macrophage cholesterol efflux
... Cellular cholesterol efflux is mediated by both active and passive processes and is regulated on multiple lev- ...and cholesterol efflux from cells and giving rise to HDL ...
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Transient Receptor Potential Ankyrin 1 Channel Involved in Atherosclerosis and Macrophage-Foam Cell Formation
... macrophage-mediated cholesterol metabolism and pro-inflammatory cytokine secretion are central steps in the initiation and progression of atherosclerosis [13, ...14]. Cholesterol levels of macrophage ...
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Plasminogen promotes cholesterol efflux by the ABCA1 pathway
... that HDL-associated APOA1 and APOE are the major mediators of macrophage CEC but that other factors promote cholesterol efflux by the ABCA1 path- ...macrophage cholesterol efflux and ...
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Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... and HDL signaling. To examine the role of cholesterol flux in HDL-mediated eNOS stimulation, we compared the effects of methyl-β-cyclodextrin (CD) and cholesterol-loaded CD with those ...
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Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
... reduced HDL chol- esterol concentrations for the first seven days of treatment ...regulates HDL cholesterol concentration has not been ...efficient cholesterol acceptor in HDL, and the ...
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HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis
... previous reports [9, 10]. In our study, DAS28, on a con- tinuous basis, showed a trend toward being inversely re- lated with CEC. Interestingly, patients with low and moderate disease activity had statistically ...
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ATP-Binding Membrane Cassette Transporter A1 (ABCA1): A Possible Link between Inflammation and Reverse Cholesterol Transport
... cellular cholesterol efflux by different mecha- ...terol efflux in HEK 293 cells and CHO cells ...dependent cholesterol efflux in THP-1 macrophages ...plasma HDL and apoA-I ...
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AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation
... of cholesterol and sphin- gomyelin ...6). Cholesterol removal from the plasma membrane reduces lipid rafts and disrupts TLR4 signaling ...deplete cholesterol from the plasma membrane in cell culture ...
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Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
... lower HDL-C in carriers of the severe mutations, causing truncations or null alleles, com- pared with carriers of missense ...in HDL-C and efflux in affected family members, suggesting that this ...
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Estrogenic Activity of Elaeis Guineensis Leaf
... Vaginal cytology assay which has been firstly used by Cook in 1933 is a reliable, sensitive, simple and inexpensive method. It is particularly used to determine the estrogenic activity of the synthetic estrogens, ...
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Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice
... regulated cholesterol metabolism we considered the balance between choles- terol biosynthesis, efflux, and its incorporation in ...circulating HDL into ...selective HDL-cholesterol ...
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Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial
... in HDL cholesterol, and a small increase in LDL cho- lesterol [13–16], although this has not always been con- firmed by real world data ...low HDL cholesterol levels, is one contributor to the ...
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Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis
... Elevation of serum ALT and AST levels is a marker of ab- normal liver function. Therefore, we further analyzed the associations between non-HDL-c/HDL-c ratio and serum ALT&AST levels. Compared with ...
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Non-HDL-cholesterol to HDL-cholesterol ratio is a better predictor of new-onset non-alcoholic fatty liver disease than non-HDL-cholesterol: a cohort study
... lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) particles that are smaller and more dense than normal [6–8] ...total cholesterol minus HDLc, is a useful predictor of ...
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