heart development
Epigenetics and Mechanobiology in Heart Development and Congenital Heart Disease
... Aside from its presence in the AVC, elevated levels of klf2a and notch1b have also been found localized to the developing OFT [137]. A recent study has shown that contractile and hemodynamic forces play independent roles ...
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Cardiomyocyte Polarity and Embryonic Heart Development: Role of Rac1
... the heart but the signaling pathways regulating this polarity are not well ...proper development of cardiac structures such as the OFT and ventricular ...downstream development of SHF-derived cardiac ...
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Hox and Tale transcription factors in heart development and disease
... During gastrulation, cardiovascular progenitors are among the first mesodermal cells to emerge from the primitive streak between E6.5 and E7.5 in the mouse embryo. Lineage tracing experiments have shown that ...
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Loss of plakophilin 2 disrupts heart development in zebrafish
... the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular ...decreased heart rate, cardiac oedema, blood pooling, a failure of the heart to pattern correctly ...
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A novel role for cardiac neural crest in heart development
... defective development of the cardiac outflow ...in heart development after cardiac neural crest ...tighter heart loops, and variable ...endocardial development appeared normal, as ...
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The Role of Claudin-5 on Xenopus Heart Development
... the heart (Xie & Brizuela, ...determining heart development and should be the first step in constructing the heart structure of ...
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Inhibitor of DNA binding in heart development and cardiovascular diseases
... in heart development and the related cardiovascular ...embryonic development, Ids play major roles in early cardiogenesis and during the entire process of the differentiation and proliferation of ...
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Multiple essential roles for primary cilia in heart development
... The recessive mouse mutant cobblestone ( cbs ) bears a hypomorphic allele of the gene Ift88 [16], leading to a reduction of Ift88 mRNA and protein levels in cbs embryos by 70% to 80% compared to wild type litter- mates. ...
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Gene environment interaction impacts on heart development and embryo survival
... first heart field and the SHF, contributing to different parts of the heart (reviewed by Buckingham et ...primary heart tube and arrested chamber development, highlighting its central ...
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Characterisation of the human embryonic and foetal epicardium during heart development
... quail heart, allowing insight into some of the morphological events associated with avian epicardium formation (Vrancken Peeters et ...foetal heart development the human ventricular epicardium ...
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Heart development and regeneration in urodeles
... Int J Dev BioI 40 719 725 (1996) 719 Heart development and regeneration in urodeles ANTON W NEFF", ARLENE E DENT' and JOHN B ARMSTRONG' IMedicaf Sciences Program, Indiana University, School of Medicin[.] ...
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Myocardin regulates BMP10 expression and is required for heart development
... cardiac development and the absence of expression of cardiac differentia- tion markers with disruption of cardiac morphological processes ...mouse heart leads to the rapid onset of dilated cardiomyopathy ...
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The ontogeny, activation and function of the epicardium during heart development and regeneration
... during development or in response to injury: a subset may proliferate and undergo EMT but may remain undifferentiated, and the fate of such cells, in either setting, remains to be ...through development ...
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QUANTITATIVE 3D RECONSTRUCTIONS AS IDENTIFICATION TOOL IN HEART DEVELOPMENT
... DNA synthesizing cells of a rat embryo of 13 days of development (E13) were labelled in utero for 24 hours with bromodeoxyuridine (BrdU) prior to sacrifice. The embryo was isolated, fixed, embedded and serially ...
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Programmed cell death during heart development
... mammalian heart initially forms as a tubular structure, with a single lumen, from a genetically pre-specified region of splanchnic mesoderm (DeRuiter et a l, 1992), and is the first organ of the body to develop ...
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Evolution and Development of Ventricular Septation in the Amniote Heart
... The evolution from the single fish ventricle to the two ventricles of mammals and archosaurs is the result of ventricular septation and has been studied and discussed for more than a century. It is tempting to apply to ...
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Lymph heart in chick somitic origin, development and embryonic oedema
... In order to examine the effects of absence of the lymph heart on the embryo, we removed all tissue below somite 33 – by ablating the tail bud at HH20-22. Fourteen embryos (out of 30) survived until E10. Six ...
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Development of the atrioventricular junctional area in the human heart
... Research was conducted on material consisting of 100 human hearts of both sexes (42 females, 58 males) from the age of 16 Hbd to 105 years of age, fixed in a formalin-ethanol solution, in which no pathologi- cal changes ...
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CYANOTIC HEART DISEASE AND PSYCHOLOGICAL DEVELOPMENT
... effects of chronic hypoxia on the percep- tual, motor, and intellectual development of children with congenital heart disease.. Within the limits of a clinical study, the di-.[r] ...
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View from the heart: cardiac fibroblasts in development, scarring and regeneration
... (Shapiro et al., 2014), a model physiologically closer to humans. The porcine model confirmed findings previously described for rodents, as virus-transduced hearts showed improved function, increased cardiomyocyte ...
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