Hematopoietic Stem Cell Niche
The hematopoietic stem cell niche: from embryo to adult
... potent niche that contains hematopoietic progenitors (Robin et ...healthy stem cells are infused into the body of the patient to replace the diseased bone marrow) because the progenitor content of ...
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Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche
... pre-pro-B cell, or pro-B cell-specific genes involved in interactions with PSS cells—as identified in Figure 4D—were highly relevant niche genes, as demonstrated by the greater significant enrichment ...
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Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
... and niche engage- ment events activated by PCa cells to coopt the HSC ...HSC niche is able to regulate dormancy of tumor cells for extend- ed ...HSC niche plays a crucial role in maintain- ing ...
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Secreted protein Del 1 regulates myelopoiesis in the hematopoietic stem cell niche
... non-dividing stem cells have also been localized around sinusoids (6, ...the niche by producing stem cell factor, pleiotrophin, and CXCL12 (6, 7, 9, 11–16) or by direct adhesive interactions ...
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Signaling in the stem cell niche: regulating cell fate, function and plasticity
... of stem cell ...adult stem cells has also been observed in the hematopoietic stem cell niche, where they generate an immunoprivileged microenvironment that promotes ...
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Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment
... HSC niche interaction is between the CXC4 chemokine receptor (CXCR4) and its ligand, stromal cell-derived factor 1α ...chymal stem cells ...marrow niche during ...
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Hematopoietic stem cell development in the placenta
... important niche cell for ...of hematopoietic stem- and progenitor cells (Robin et ...putative niche cell types are shared with other hematopoietic organs, the tropho- ...
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The stem cell niche: tissue physiology at a single cell level
... complex hematopoietic phenotype with multiple defects at the stem cell, progenitor, and mature cell level, creating a myelodysplasia-like state ...of stem cells to progenitors and ...
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Effects of Mesenchymal Stem Cell Derivatives on Hematopoiesis and Hematopoietic Stem Cells
... Signaling pathways and cellular interactions adjust the BM niche for HSPCs. MSCs produce numerous paracrine agents, and it may be difficult to investigate the mechanisms accountable for the production of ...
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Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche
... mesenchymal stem cells with the REH‑conditioned medium we showed that hematopoietic stem cells, normally in a quiescent state, enter cell cycle and ...well‑known cell ...
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Engineering a multicellular vascular niche to model hematopoietic cell trafficking
... perivascular niche in vivo, we engi- neered a 3D microvessel network in collagen gel com- bining lithography and injection molding processes as described previously ...HS27a cell lines, were embedded ...
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Adhesion in the stem cell niche: biological roles and regulation
... adult stem cells reside in the body and undergo continuous self-renewal throughout an organism’s ...of stem cells, is collectively referred to as the stem cell niche (Spradling et ...
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Ex vivo expansion of Hematopoietic Stem cells for Therapeutic purposes: Lessons from development and the niche
... adult stem cells and fetal ...development, stem cell maintenance and tissue ...in cell fate, proliferation and survival, while the non-canonical pathway is more involved in differentiation, ...
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Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche
... the cell cycle of non-hematopoietic cells, we studied the effect of RHOAV14 and RHOAN19 expression on the cell cycle status of ...the cell cycle in RHOAV14 expressing HSPC compared to control ...
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Hematopoietic Stem Cell Biology
... of niche occupancy may exert some modulatory effect on the recruitment of T-cell precur- sors through expression of putative endothelial thymus homing receptors and/or the release of chemotactic factors ...
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Targeting stem cell niche can protect hematopoietic stem cells from chemotherapy and G-CSF treatment
... the niche and disrupt HSC functions such as quiescence, proliferation, and self-renewal ...osteoblast niche was impaired by multiple rounds of cytotoxic drug treatment before G-CSF mobilization, in which ...
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Dormancy in the stem cell niche
... c cell surface markers allowed the isolation, purifi cation, and func tional characterization of HSCs in vitro and in vivo, leading to the recent identifi cation of a population of highly quiescent, ...
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Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells
... blood stem cell ...of hematopoietic progenitors that can lodge and mature in the ...vascular niche to an in vivo BM niche supports their maturation from precursor to ...of ...
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The spermatogonial stem cell niche in testicular germ cell tumors
... many stem cell populations, including embryonic, hematopoietic, and neural stem cells among ...of stem cell characteristics, hypoxia alters the Notch1 signaling pathway and ...
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Hemmule: A Novel Structure with the Properties of the Stem Cell Niche
... large size cells, cells inside bone marrow vessels, cells around footprints, and are scattered around. 442.[r] ...
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