Heme biosynthesis
Staphylococcus aureus HemX Modulates Glutamyl tRNA Reductase Abundance To Regulate Heme Biosynthesis
... for heme biosynthesis, and the corresponding genes often colocalize on the ...novo heme synthesis, as hemX never occurs in a genome without gtrR, and hemX never occurs without the capacity for de ...
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Sampangine Inhibits Heme Biosynthesis in both Yeast and Human
... Upon individual validation, we identified 132 haploid deletion mutants that were significantly more sensitive to sampangine at 0.5 g/ml than a wild-type strain (see Table S1 in the supple- mental material). Highly ...
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Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis
... increased heme biosynthetic genes, with UROD associating with poor ...the heme metabolism path- way was upregulated (Supplemental Figure 1A; supplemental material available online with this article; ...the ...
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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis
... 2B) and lower levels of heme synthesis (45% and 65% reductions, respectively, Figure 2C), as suggested by the loss of red pigmen- tation. Total iron accumulation was slightly lower in cells dif- ferentiating under ...
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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
... cluster biosynthesis and the maintenance of normal mitochondrial and cytosolic iron homeostasis in human ...cluster biosynthesis was impaired, the ...
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Porphyrin heme biosynthesis in organotypic cultures of mouse dorsal root ganglia Effects of heme and lead on porphyrin synthesis and peripheral myelin
... and heme together for 6 wk, the segmental demyelination seen in cultures treated with lead alone did not ...the heme biosynthetic pathway in myelinating cells and that exogenous heme may counteract ...
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Frataxin, a Conserved Mitochondrial Protein, in the Hydrogenosome of Trichomonas vaginalis
... The frataxin sequence identified in T. vaginalis possesses features typical of the protein family as found for the human and yeast homologues. Conserved acidic residues implicated in iron binding are found at the N ...
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... ORIGINAL ARTICLE Diagnosis Of Porphyria By Measuring Metabolites Of Heme Biosynthesis In Correlation With Clinical Findings SORTE K *, PALANDURKAR K **, GOYAL M ***, SINGH A L ****, BASA[r] ...
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An update of clinical management of acute intermittent porphyria
... with heme preparations, if an acute attack is severe or moderate; 2) symptomatic treatment of autonomic dysfunctions, polyneuropathy and encephalopathy; 3) exclusion of pre- cipitating factors; and 4) adequate ...
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The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation
... to heme are also highly susceptible to altered expression of Flvcr1 ...allows heme biosynthesis and heme efflux into the cytosol, a process essential for hemoglobinization and ery- throid ...
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Engineering Corynebacterium glutamicum to produce 5-aminolevulinic acid from glucose
... and heme production and causes the cultures to become red ...regulate heme synthesis ...of heme, which are compo- nents of oxygen-binding and regulatory proteins as well as those of the electron ...
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Pharmacological Inhibition of Host Heme Oxygenase 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes
... identify heme oxygenase-1 (HO-1) as a po- tential target for HDT of ...catalyzes heme degradation into biliverdin, iron, and carbon monoxide (3), is induced during both experimental and clinical ...
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PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis
... for heme acquisition by ...using heme as an iron source versus the siderophore-mediated utilization of ferric citrate (26 and 11 days, respectively ...ever, heme acquisition by ...of ...
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Coordinate expression of heme and globin is essential for effective erythropoiesis
... of heme export via FLVCR1 and, consequently, an increase in intracellular heme, we sorted developing erythroblasts and measured total cellular heme con- tent from pooled marrow ...The heme ...
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The biosynthesis of porphyrins and haems
... 1 The biosynthesis of porphyrins and haems* 3 3* Glycine in haem biosynthesis* 8 4* Acetate in haem biosynthesis* 10 5* The citric acid cycle and haem biosynthesis* 6* 6-aminolaevulic ac[r] ...
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Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
... of heme proteins by inducing the heme- degradative enzyme, heme oxygenase, as well as increasing the synthesis of ferritin, the major cellular repository for ...
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Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction
... Please cite this article as: Spencer, C.S., Yunta, C., Gomes de Lima, G.P., Hemmings, K., Lian, L.-Y., Lycett, G., Paine, M.J.I., Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding ...
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Diverse protein regulations on PHA formation in Ralstonia eutropha on short chain organic acids
... histidine. Biosynthesis of three aro- matic amino acids, phenylalanine, tyrosine, and tryptophan uses a shared starting compound as phos- phoenolpyruvate ...
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A New Approach to Understanding Biological Control of Quinone Electrochemistry
... hydroquinone, semiquinone and oxidized states of their substrate quinones. This level of control allows for maximization of conversion efficiency between the energy of the quinone reducing equivalents and the proton ...
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Staphylococcus lugdunensis IsdG Liberates Iron from Host Heme
... Both heme oxygenases are transcriptionally regulated by Fur in response to iron levels; however, in the absence of heme, IsdG is targeted for proteolytic degradation ...control heme degradation. S. ...
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