heparan sulfate proteoglycan
Heparan Sulfate Proteoglycan Agrin in CNS Development and Aging
... I-HSUAN. Heparan Sulfate Proteoglycan Agrin in CNS Development and ...matrix heparan sulfate proteoglycan and is best known for its role as the organizer of the neuromuscular ...
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Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin
... of heparan sulfate proteoglycan-dependent functions in inflammatory ...involve heparan sulphate ...of heparan sulfate proteoglycans was tested by their chemical modification and ...
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Human Rhinovirus Type 89 Variants Use Heparan Sulfate Proteoglycan for Cell Attachment
... We now demonstrate that one of these variants utilizes heparan sulfate proteoglycan (HSPG) as a cellular receptor. Adaptation to ICAM-1-deficient cells not only resulted in the newly acquired ...
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Genogroup II Noroviruses Efficiently Bind to Heparan Sulfate Proteoglycan Associated with the Cellular Membrane
... surface heparan sulfate ...surface heparan sulfate, as well as the enzymes that specifically digest heparan sulfate, markedly reduced VLP binding to the ...of heparan ...
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Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses
... IMPORTANCE AKAV and SBV are the etiological agents of arthrogryposis-hydranencephaly syndrome in ruminants, which causes considerable economic losses in the livestock industry. Here, we identified heparan ...
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The Association between Genes Polymorphisms of Heparan Sulfate Proteoglycan 2 (HSPG2) and Chondroitin Sulfate Proteoglycan 2 (CSPG2) and Intracranial Aneurysm Susceptibil-ity: A Meta-Analysis
... the heparan sulfate proteoglycan 2 (HSPG2) and chondroitin sulfate proteoglycan 2 (CSPG2) genes have been identified as suscepti- bility genes for IA (12, ...
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Membrane-Associated Heparan Sulfate Proteoglycan Is a Receptor for Adeno-Associated Virus Type 2 Virions
... that heparan sulfate proteoglycans mediate both AAV attachment to and infection of target ...of heparan but not chondroitin sulfate moieties from the cell surface greatly reduced AAV ...
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Heparan Sulfate Proteoglycan Binding Properties of Adeno-Associated Virus Retargeting Mutants and Consequences for Their In Vivo Tropism
... Adeno-associated virus type 2 (AAV-2) targeting vectors have been generated by insertion of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates binding of heparan ...
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Interaction of poly-L-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells
... of heparan sulfate from heparan sulfate proteoglycans of the cell surface by heparinase III significantly reduced MNP cell ...PLL-heparan sulfate proteoglycan interaction ...
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Chinese hamster ovary cell adhesion to human platelet thrombospondin is dependent on cell surface heparan sulfate proteoglycan
... decreased heparan sulfate proteoglycan but increased chondroitin sulfate proteoglycan, had 42% ...decreased heparan sulfate proteoglycan and normal chondroitin ...
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Perlecan Heparan Sulfate Proteoglycan
... Cell surface heparan sulfate proteoglycans (HSPGs) participate in the catabolism of many physiologically important ligands. We previously reported that synde- can HSPGs directly mediate endocytosis, ...
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Heparan sulfate proteoglycan induces the production of NO and TNF-α by murine microglia
... Background: A common feature of Alzheimer's disease (AD) pathology is the abundance of activated microglia in neuritic plaques containing amyloid-beta protein (A β ) and associated mole[r] ...
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Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity
... oligosaccharides, sulfate groups lying on opposite sides of the helix can interact with positive residues on two peptide sequences of the branched structure, thus favoring multivalent binding, and explaining the ...
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Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin
... Abbreviations used in this paper: ARTN, artemin; BDNF, brain-derived neuro- trophic factor; FRET, Förster resonance energy transfer; GABA, -aminobutyric acid; GDNF, glial cell li[r] ...
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Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder
... protamine sulfate or the addition of purified platelet Factor 4 (PF4) to the ...The proteoglycan isolated had a mol wt of 116,000 and appears to consist of two 38,000 dalton polysaccharide units ...
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toutvelu, a Regulator of Heparan Sulfate Proteoglycan Biosynthesis, Controls Guidance Cues for Germ-Cell Migration
... To gain further insight into the mechanisms that di- rect germ-cell migration and the role of the hh-signaling pathway in this process, we carried out a screen for germ-cell migration defects using deficiencies spanning ...
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Syndecan 1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride rich lipoproteins in mice
... of heparan sulfate in hepatocytes is diminished, as this alters hepatic lipoprotein clearance via heparan sulfate proteoglycans ...available proteoglycan-deficient mice showed that only ...
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Delayed catabolism of apoB 48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice
... the delay in clearance of apoB-48–containing lipopro- teins. A similar effect may explain why apoE-null mice, for whom HSPG may constitute the principal residual apoB-48–clearance pathway, develop partic- ularly marked ...
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Identification of Amino Acid Residues in the Capsid Proteins of Adeno-Associated Virus Type 2 That Contribute to Heparan Sulfate Proteoglycan Binding
... Intact capsids were assayed for their ability to bind to heparin-agarose in vitro, and virions that packaged DNA were assayed for their ability to transduce normally permissive cell lines. We found that mutation of ...
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Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression
... The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of ...
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