Heparin Binding
Heparin-binding protein is important for vascular leak in sepsis
... Heparin-binding protein (HBP), also known as azurocidin or CAP37, is stored in secretory vesicles and azurophilic granules of neutrophils and is released early upon neutrophil adhesion and during neutrophil ...
16
Role of Heparin Binding in Plasmin-mediated Activation of TAFI and Thermal Stability of TAFIa
... of heparin, when compared to the wild-type ...of heparin. When examining the effect of heparin on the half-lives of all of the above variants, half-life fold increase is the lowest for K327A, ...
111
Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles
... specific binding-mediated particle incorporation. Heparin-binding proteins were chosen for the incorporation as DS in the outer shell of DSCS NPs is an analog of ...A heparin-binding ...
11
Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV 1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines
... receptor binding, but appear to block members of the DBL with either known GAG or chemokine binding ...DARC binding and has specific sulfated polysaccharide binding proper- ties that ...
11
Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix
... nucleotide binding (28, ...⫹ binding involves a large conformational change ...impaired heparin binding and, thus, that they both contribute to form a single binding surface, it could ...
14
Heparin-binding protein in ventilator-induced lung injury
... Heparin-binding protein (HBP) is a protein found in the vesicles of neutrophil granu- locytes. It has been shown to have several properties contributing to the inflammatory process, and its ability to ...
11
Proposed heparin binding site in antithrombin based on arginine 47 A new variant Rouen II, 47 Arg to Ser
... prime heparin binding site in antithrombin and that it forms part of a proposed positively charged linear site (to which heparin binds) that stretches across the surface of the molecule from the A to ...
6
Role of the heparin-binding domain in intracellular trafficking of sHB-EGF
... of heparin-binding domain) forms of HB-EGF that were fluorescently-labeled with mCherry or ...of heparin- binding domain of HB-EGF in the process of its binding to receptors and ...
7
Augmented production of heparin binding mitogenic proteins by preadipocytes from massively obese persons
... the heparin-binding (fibroblast) growth factor family was indicated by Western blot analysis, for a 66-kD protein with anti-(1-24)bFGF, and for a 32-kD protein with anti-(40-63)bFGF ...of ...
7
Identification and Analysis of a Novel Heparin-Binding Glycoprotein Encoded by Human Herpesvirus 7
... putative heparin-binding motifs (individually or in com- bination). Heparin-binding by these full-length mutant deriv- atives of gp65 was then ...of binding to heparin in a ...
11
Heparin binding defective lipoprotein lipase is unstable and causes abnormalities in lipid delivery to tissues
... its heparin affin- ...(LRP) binding and presumably other members of this family of receptors includes amino acids 404–430 (36), a region that includes the carboxyl terminal heparin-binding ...
11
Localization of heparin binding EGF like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques
... Heparin-binding EGF-like growth factor (HB-EGF) is a potent chemoattractant and mitogen for smooth muscle cells (SMC) in culture. To elucidate whether HB-EGF is implicated in the pathogenesis of human ...
9
Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury
... Plasma heparin-binding protein levels from patients with acute lung injury and healthy volunteers were measured by ...plasma heparin-binding protein were significantly higher in patients with ...
6
Isolation, characterization, and localization of heparin binding growth factors in the heart
... Acidic and basic fibroblast growth factors (aFGF and bFGF) are angiogenic polypeptide mitogens for cells of mesodermal and neuroectodermal origin. In this report we describe the purification from several normal human ...
10
The role of Heparin-binding proteins in normal pancreas and acute pancreatitis
... HS- binding proteins will necessarily bind the heparin column and may, instead remain bound to HSPGs during affinity ...than heparin (Ori et ...of heparin, which makes up 75% of the ...
196
In silico analyses of heparin binding proteins expression in human periodontal tissues
... of heparin in periodonti- tis, where it alters MMP/TIMP complexes circulating in blood, and increases release of TIMP-2 ...[11]. Heparin/HS, HBPs and MMPs are, thus, important in ...
7
Participation of heparin binding proteins from the surface of Leishmania (Viannia) braziliensis promastigotes in the adhesion of parasites to Lutzomyia longipalpis cells (Lulo) in vitro
... The strong binding of L. (V.) braziliensis to GAGs observed in the performed physicochemical assays rein- forces the putative function of the 65.0 kDa and 55.0 kDa proteins of promastigotes as important adher- ent ...
10
Effect of buffer on heparin binding and sensing in competitive aqueous media
... A binding study of MalB with heparin in different buffer systems was performed using UV-Vis ...and heparin was titrated into the ...of heparin is relatively challenging, as it is a ...
20
Identification of Amino Acid Residues in the Capsid Proteins of Adeno-Associated Virus Type 2 That Contribute to Heparan Sulfate Proteoglycan Binding
... of heparin, and use of mutant cell lines that express various levels of HSPG (16, 37, 46, ...51). Binding to HS is usually the result of electrostatic charge interactions between basic amino acids (R, K, ...
12
Specificities of the interaction of fibroblast growth factor and heparan sulfate
... similar heparin binding sites compared to FGFs from different subfamilies ...HS binding properties of the paracrine FGFs were selected for during the divergence and expansion of the FGF family that ...
204