hepatic insulin resistance
Activation of hypothalamic S6 kinase mediates diet induced hepatic insulin resistance in rats
... by insulin and nutrients leads to inhibition of insulin signaling via negative feedback input to the signaling factor ...enhances insulin sensitivity in ...diet-induced hepatic insulin ...
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Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
... in hepatic insulin ...the insulin receptor in vivo and impairs insulin receptor kinase activity both in vivo and in ...fat-induced hepatic insulin resistance and ...
8
Adipocyte JAK2 mediates growth hormone–induced hepatic insulin resistance
... confers insulin sensitivity throughout ...to insulin resistance, risk of dia- betes, and increased ...whole-body insulin and glucose ...and hepatic insulin sensitivity, protects ...
15
Association of Alanine Aminotransferase Levels (ALT) with the Hepatic Insulin Resistance Index (HIRI): a cross-sectional study
... increment in ALT, HIRI increased by 0.9 and 1.0 unit re- spectively. In subjects with T2DM (model 6), an incre- ment of 3 units of HIRI could be expected for the same 10 IU/L increment in ALT. This progressive increment ...
9
Probing the role of stearoyl CoA desaturase–1 in hepatic insulin resistance
... obesity, insulin resistance, and ...and hepatic ste- ...of hepatic SCD1 is sufficient to prevent diet-induced hepatic insulin resistance, signifying an important role of ...
5
Critical role of stearoyl CoA desaturase–1 (SCD1) in the onset of diet induced hepatic insulin resistance
... of hepatic Akt activity can per se decrease blood glucose and insulin levels, induce fatty liver, and suppress the expression of Glc-6-Pase and PEPCK within just 4 days ...of hepatic Akt, they are ...
11
Hypothalamic resistin induces hepatic insulin resistance
... controlling hepatic glucose homeostasis in response to hypothalamically initiated hormonal ...(i.e., insulin and leptin) (36–38) and nutritional ...via hepatic effects and indi- rectly through a ...
10
Association of moderately elevated trimethylamine N-oxide with cardiovascular risk: is TMAO serving as a marker for hepatic insulin resistance
... mediate hepatic insulin resistance, it serves as a marker for the increased FFA influx that ...promote hepatic insulin ...ameliorating hepatic insulin ...of hepatic ...
8
Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... patic insulin resistance is generated from modifications in IRS1 tyrosine phospho- rylation, leading to its impaired function and, ultimately, to disruption of insulin signal transduction in the ...
9
Reversal of diet induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl CoA carboxylases 1 and 2
... to hepatic insulin ...and hepatic insulin resistance to explore the impact of suppressing Acc1, Acc2, or both Acc1 and Acc2 on hepatic lipid levels and insulin ...reduce ...
9
Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male rats
... Hepatic insulin resistance recently received increasing attention. Gluconeogenesis is a major source of fasting EGP, which maintains the body's fasting blood glucose at normal levels [23,24]. In ...
11
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
... plasma insulin levels and visceral adiposity in humans (1–3, 8–10) and in animal models (23, ...of insulin on hepatic glucose fluxes in a well-characterized rodent model of aging (23, ...reverse ...
10
Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques
... to hepatic insulin resistance [18,19] the predictive value of the index further improved (r 2 = 56%) but the additional gain of accuracy is obtained at considerable increased costs due to the state ...
10
Role of resistin in diet induced hepatic insulin resistance
... Diet-induced insulin resistance is a relevant model for the most common forms of insulin resistance in ...of hepatic insulin resistance typically precedes the appear- ance ...
9
Insulin receptor Thr1160 phosphorylation mediates lipid induced hepatic insulin resistance
... in hepatic insulin resis- tance, is caused by hepatic insulin resistance, or is unrelated to hepatic insulin resistance is actively ...dissociated hepatic ...
12
Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study
... process: insulin resistance influencing post- prandial lipoprotein response or instead the exaggerated postprandial response favouring the insulin resistance ...of hepatic ...
10
Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene
... peripheral insulin resistance? While a modest decrease in postabsorptive HGP was present in the GLUT4 ( 1/2) compared with the WT (1/1) mice, the basal rate of glucose clearance was not significantly ...
10
Glycerol-3-phosphate acyltransferase isoforms : hepatic triacylgycerol synthesis and the development of insulin resistance
... with insulin resistance and type 2 diabetes, but it is unclear whether triacylglycerol accumulation or an excess flux of lipid intermediates in the pathway of TAG synthesis are sufficient to cause ...
149
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
... by hepatic steatosis. Increased hepatic lipogenesis contributes to both of these ...Because insulin fails to suppress gluconeogenesis but continues to stimulate lipogenesis in both obese and ...
9
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
... severely insulin resistant, as reflected by the very low rates of glucose infusion required to maintain euglycemia during the hyperinsulinemic-euglycemic clamp (lipodystrophic, ...in insulin-stimulated ...
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