hepatic stellate cell
hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
... In this study, we demonstrated that similar with the hUCMSCs, hUCMSC-EVs also have the capacity to alleviate S. japonicum-induced liver damage. More importantly, hUCMSC-EV-mediated amelioration of liver injury con- ...
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Unfolded protein response is an early, non-critical event during hepatic stellate cell activation.
... Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix ...mouse hepatic stellate cells in vitro and in vivo, prior to ...
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Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway
... Figure 1. l eucine-rich repeats and immunoglobulin 1 (LRIG1) expression in carbon tetrachloride (CCl4)-induced liver fibrosis and activated hepatic stellate cell (HSC) cells. Figure 1A. H & E ...
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Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis
... the cell of origin, they facilitate cell-to-cell communica- tion, and after being internalized by the target cell, they can modulate several cell responses as well as gene expression ...
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Original Article Inhibitory effects of dimethyl α-ketoglutarate in hepatic stellate cell activation
... of Hepatic stellate cell (HSC) is a pivotal event in the initiation and progression of he- patic fibrosis and a major source of collagen ...hepatocyte cell lines were treated with DMKG at ...
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Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway
... Human hepatic stellate cell line (HSC) LX-2 was used for in vitro ...induce hepatic fibrosis in LX-2 ...CCl4-induced hepatic fibrosis in SD rats was used as an in vivo ...TGF-β1-induced ...
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Original Article Blockade of IGFBPrP1 attenuates canine hepatic fibrosis induced by thioacetamide via inhibition of hepatic stellate cell activation
... ed from the TAA group at weeks 0, 3, 6, 9, and 12 revealed that different stages of liver fibrosis had been successfully established in the 6 beagles. After 3 weeks of TAA adminis- tration, compared with the control, the ...
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Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo
... in the presence of the MFD. The cells were collected by trypsin-EDTA and lysed in RIPA buffer (50 mM Tris- HCl, 1 mM EDTA, 150 mM NaCl, 1 % NP-40) contain- ing protease inhibitors. After mixing for 30 min at 4 °C, the ...
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Original Article Hepatitis B virus X protein maintains hepatic stellate cell activation by regulating peroxisome proliferator-activated receptor γ
... ic, hepatic stellate cells still have dominated the study of fibrosis [1, ...stimuli, hepatic stellate cells (HSCs) are activated, changing from a quiescent vita- min A-storing phenotype to a ...
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Original Article Establishment and characterization of an immortalized rat hepatic stellate cell line
... Abstract: Hepatic stellate cells (HSCs) play an important role in liver fibrosis and portal ...HSC cell line ...LSC-1 cell biological characteristics were studied. LSC-1 cell have been ...
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Mechanisms of spontaneous resolution of rat liver fibrosis Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
... We have used highly pure cultures of activated stellate cells to confirm that activated HSCs undergo apoptosis in cell cul- ture. The model of activation by culture on plastic in the pres- ence of serum has ...
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Mitochondrial uncouplers inhibit hepatic stellate cell activation
... We show that different aspects of human and mouse HSC activation such as α-SMA expression and prolifera- tion are inhibited by chemical mitochondrial uncoupling. One important aspect of activated HSC is the capacity to ...
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miRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation
... miR-338 precursor to repair its loss at the early stage of primary HSCs. On day 7, cells transfected with miR-338 precursor showed a more original shape with less per- ipheral protrusions. However, the control group ...
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Original Article Suppression of hedgehog signaling regulates hepatic stellate cell activation and collagen secretion
... Rat HSCs were isolated from normal Wistar rats by liver ex vivo perfusion of collagenase type IV and density gradient centrifugation methods [17-20]. Isolated HSCs were seeded on uncoated plastic tissue culture dishes ...
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Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
... TAA causes toxicity in hepatocytes and then induces acute and chronic liver injury through free radical and oxidative stress [24]. The first step of TAA metabolism is through flavin-adenin dimucleotide (FAD)-containing ...
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Original Article Epigenetic histone methylation regulates MMP-1 expression in myofibroblastic hepatic stellate cell
... The increased collagenase activity in the early stages of liver fibrosis, which had been ob- served by a large number of studies, initially could not be correlated with the results of established gene expression ...
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1 Rap1 regulates hepatic stellate cell migration through
... gtpase rap1 regulates cell migration through regulation of small gtpase rhoa activity in response to 405. transforming growth factor-beta1[r] ...
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Suppression of hepatic stellate cell activation through downregulation of gremlin1 expression by the miR-23b/27b cluster
... of hepatic fibrosis of CCl4-induced model SD rats through siRNA knockdown of gremlin1 is associated with BMP-7, the expression of the protein in liver tissue was detected via ...attenuates hepatic fibrosis ...
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Hepatic stellate cells and parasite induced liver fibrosis
... The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well investigated over the last few years in a number ...
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Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis
... reduce hepatic venous pressure and increase hepatic perfusion in patients with cirrhosis (Albraldes, ...of hepatic stellate cell of the liver (Shirin et al, 2013), reducing ...
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