hepatic stellate cell(s)
hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
... In this study, we demonstrated that similar with the hUCMSCs, hUCMSC-EVs also have the capacity to alleviate S. japonicum-induced liver damage. More importantly, hUCMSC-EV-mediated amelioration of liver injury ...
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Leucine-rich Repeats and Immunoglobulin 1 (LRIG1) Ameliorates Liver Fibrosis and Hepatic Stellate Cell Activation via Inhibiting Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P) Pathway
... Figure 1. l eucine-rich repeats and immunoglobulin 1 (LRIG1) expression in carbon tetrachloride (CCl4)-induced liver fibrosis and activated hepatic stellate cell (HSC) cells. Figure 1A. H & E ...
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Original Article Inhibitory effects of dimethyl α-ketoglutarate in hepatic stellate cell activation
... of Hepatic stellate cell (HSC) is a pivotal event in the initiation and progression of he- patic fibrosis and a major source of collagen ...hepatocyte cell lines were treated with DMKG at ...
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Unfolded protein response is an early, non-critical event during hepatic stellate cell activation.
... Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix ...mouse hepatic stellate cells in vitro and in vivo, prior to ...
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miRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation
... in cell cycle regulation. Activation of cyclin D—CDK4 promotes the cell cycle progression through G1/S transition ...miR-338-3p-inhibited cell activation and ...
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Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
... reduced hepatic collagen content by down-regulating hepatic expression of type I and III col- lagen and/or decreasing the serum levels of type III pro- collagen and type IV ...
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Original Article Suppression of hedgehog signaling regulates hepatic stellate cell activation and collagen secretion
... Rat HSCs were isolated from normal Wistar rats by liver ex vivo perfusion of collagenase type IV and density gradient centrifugation methods [17-20]. Isolated HSCs were seeded on uncoated plastic tissue culture dishes ...
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Original Article Establishment and characterization of an immortalized rat hepatic stellate cell line
... Rat HSCs were isolated from normal Wistar rats by liver ex vivo perfusion of collagenase type IV and density gradient centrifugation methods [20-23]. Isolated HSCs were seeded on uncoated plastic tissue culture dishes ...
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Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
... TAA causes toxicity in hepatocytes and then induces acute and chronic liver injury through free radical and oxidative stress [24]. The first step of TAA metabolism is through flavin-adenin dimucleotide (FAD)-containing ...
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Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo
... extensively used in animal models to evaluate the thera- peutic potential of drugs. On the other hand, plants of the Dendrobium genus (Orchidaceae) are used in tradi- tional herbal medicines in Asia, and studies have ...
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Original Article Blockade of IGFBPrP1 attenuates canine hepatic fibrosis induced by thioacetamide via inhibition of hepatic stellate cell activation
... attenuated hepatic fibrosis, as assess- ed by the decreased collagen deposition and less advanced stage of fibrosis ...single stellate cell usually surrounds more than two nearby sinusoids, where the ...
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Mechanisms of spontaneous resolution of rat liver fibrosis Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
... the process of fibrosis as the major source of fibrillar and non- fibrillar matrix proteins (1). Quiescent HSC synthesize low levels of matrix proteins, but, as a result of injury, HSCs prolif- erate and transform to a ...
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The role of miR-29a in the regulation, function, and signaling of liver fibrosis
... 12. Bandyopadhyay, S.; Friedman, R. C.; Marquez, R. T.; Keck, K.; Kong, B.; Icardi, M. S.; Brown, K. E.; Burge, C. B.; Schmidt, W. N.; Wang, Y.; McCaffrey, A. P., Hepatitis C virus infection and ...
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Mitochondrial uncouplers inhibit hepatic stellate cell activation
... a major role during HSC activation stimulating several pathways related to the activation process [13]. After 30 minutes, FCCP and Valinomycin reduced ROS levels to 50% and 80% of control cells respectively (Figure 1B). ...
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1 Rap1 regulates hepatic stellate cell migration through
... gtpase rap1 regulates cell migration through regulation of small gtpase rhoa activity in response to 405. transforming growth factor-beta1[r] ...
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Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
... The discovery of the molecular basis underlying the pathophysiological mechanisms of human disease is a step of paramount importance for the discovery of effective therapies. In this regard, while advanced liver fibrosis ...
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Mucosal-Associated Invariant T cell in liver diseases
... Mucosal-associated invariant T cells (MAIT cells) are a new population of innate immune cells, which are abundant in the liver and play complex roles in various liver diseases. In this review, we summarize MAIT cells in ...
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PubMedCentral-PMC5175173.pdf
... Cell culture models for monocyte/macrophage and hepatic stellate cell activation. Human PBMCs were isolated from buffy coats of healthy HIV/HBV/HCV sero/qPCR negative blood donors by ...
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Hepatic stellate cells in liver development, regeneration, and cancer
... studying hepatic stellate cell–HCC interactions in transgenic mouse models of HCC has been somewhat limited, with the notable exception of the PDGF-C transgenic mouse ...show hepatic ...
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Effect of simvastatin on the transforming growth factor β1, fibroscan scores, and aspartate transaminase to platelet index ratio patients with Liver Cirrhosis
... reduce hepatic venous pressure and increase hepatic perfusion in patients with cirrhosis (Albraldes, ...of hepatic stellate cell of the liver (Shirin et al, 2013), reducing ...
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