hepatitis B virus X
Hepatitis B Virus X Protein Interferes with Cellular DNA Repair
... The hepatitis B virus X protein (HBx) is a broadly acting transactivator implicated in the development of liver ...tumor-associated virus might contribute to ...
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Upregulation of MicroRNA 146a by Hepatitis B Virus X Protein Contributes to Hepatitis Development by Downregulating Complement Factor H
... in hepatitis B virus (HBV) patients are caused by immune responses of the ...HBV X protein (HBx) was responsible for its effects on miR-146a expression through NF-B-mediated ...
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Hepatitis B Virus X Protein Function Requires Zinc Binding
... Biophysical analyses of recombinant HBx indicate that C61, C69, C115, and C137 are involved in zinc binding. We next performed mass spectrometry-based hydrogen-deuterium exchange (HDX) analysis of the coexpressed ...
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Molecular characterization of hepatitis B virus X gene in chronic hepatitis B patients
... Analysis was performed by comparison of the obtained gene sequences, with HBV reference sequences for each genotype, available at GenBank. HBV-X sequences were aligned using ClustalX software 1.81 version [27]. ...
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Mutations at Nucleotide 1762, 1764 and 1766 of Hepatitis B Virus X Gene in Patients with Chronic Hepatitis B and Hepatitis B-Related Cirrhosis
... chronic hepatitis B and 34 patients with cirrhosis, with confirmed diagnosis by a doctor using ...the X gene at nucleotide positions 1374 to 1836 of the HBV genome, a pair of external primers and a ...
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Mapping of B-cell epitopes of the human hepatitis B virus X protein.
... The carboxy-terminal half of the HBx antigen was the most frequent target for anti-HBx antibodies in sera of patients with viral hepatitis and contained an immunodominant antigenic regio[r] ...
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trans-activation of viral enhancers by the hepatitis B virus X protein.
... b X protein for trans-activating the HBV enhancer was derived from pSVX by co-transfecting this plasmid with pHBE7 into PLC/PRF/5 cells, and pEN4 provided the X protein for the trans-act[r] ...
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Hepatitis B virus x protein induces epithelial mesenchymal transition of hepatocellular carcinoma cells by regulating long non coding RNA
... Fig. 3 ZEB2-AS1 was an important lncRNA that mediated HBx-induced EMT. a The level of ZEB2-AS1 was verified by a real-time PCR assay. The siRNA can effectively inhibit the level of ZEB2-AS1. b Transwell assay. ...
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The Role of HBx-mediated Transcriptional Activities and Epigenetic Alterations in Hepatitis B Virusinduced Hepatocellular Carcinoma
... HBV is a non-cytopathic hepadnavirus transmitted prenatally, sexually and percutaneously. More than 350 million people are chronically infected worldwide and 1million die from infection annually as a result of hepatic ...
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Characterization of the hepatitis B virus EnhI enhancer and X promoter complex.
... Since the 2c site is essential for the liverspecific activity of the basal enhancer module, the reduction of X promoter activity in liver cells is likely due to loss of the liver-specifi[r] ...
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Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice.
... Although the expression of mouse AAT protein in the transgenic mice remained high throughout the life span of the animals 43, the pattern of transgene expression in the ATX transgenic mi[r] ...
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Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans.
... To unambiguously demonstrate the specificity of the antigen-antibody interactions, we used a mixture of 35S-labeled polypeptides synthesized by in vitro coupled transcription-translation[r] ...
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Original Article Association of hepatitis B virus basal core promoter T1762/A1764 and precore A1896 mutations with serum hepatitis B virus DNA load, hepatitis B e antigen status, serum α-fetoprotein and hepatitis B virus-related liver disease progression
... Serum virus DNA was extracted using the TIANamp virus DNA/RNA kit (DP315, Tiangen Biotech ...HBV X gene fragment containing the BCP 1762/1764 and PC 1896 sites was amplified by nested ...
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Mutations in hepatitis B virus small <em>S</em> genes predict postoperative survival in hepatocellular carcinoma
... Abstract: Hepatitis B virus (HBV) DNA is prone to mutations due to proofreading deficiencies of HBV ...the X, precore, and core ...HBV B genotype, 52 patients with HBV C genotype, and 3 ...
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The Enigmatic X Gene of Hepatitis B Virus
... with an HBx expression vector that included the HBV X cod- ing sequence as well as the HBV enhancer I region, the X gene promoter, and the HBV polyadenylation signal (Fig. 1). Using an identical expression ...
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2359.pdf
... "Following the identification of hepatitis A and hepatitis B, this disorder was categorized in 1974 as 'non-A, non-B hepatitis.' In 1989, the hepatitis C virus was identified and[r] ...
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Seroprevalence of hepatitis B virus surface antigen (HBsAg) among clients visiting ‘Tefera Hailu’ memorial hospital, Sekota, Northern Ethiopia
... General, hepatitis B virus (HBV) infection and its squelae (cirrhosis and liver cancer) are major global health problems mostly in developing countries includ- ing ...
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Influence of Hepatitis B and Hepatitis C Virus Infections and Human Immunodeficiency Virus Therapy on Liver Status of Patients with Human Immunodeficiency Virus
... A similar finding to the present study revealed that ALT level of HIV/HCV co-infected patients under HAART, during the first year of treatment, was at least 5 fold greater than that of pre- HAART [36]. HCV has been ...
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Cost-effectiveness of birth-dose hepatitis B vaccination among refugee populations in the African region: a series of case studies
... chronic hepatitis, cirrhosis and HCC, and the cost of operations according to triangular distributions, with the lower and upper bounds of vaccination coverage repre- senting the worst and best performing ...
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Clinical and biochemical profile of patients with viral hepatitis at tertiary care centre
... of hepatitis symptoms including: weakness, lethargy, early fatigue, joint pains, jaundice (yellow skin) and Abdominal pain; an elevated liver enzymes; and positivity of serological markers for of HAV, HBV, HCV, ...
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