Hepatocyte apoptosis
Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection
... of hepatocyte apoptosis fol- lowing ...Fas-mediated apoptosis and caspase activation, which aggravated tissue injury by increasing apoptosis [25, ...hepatic apoptosis and the ...
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Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice
... Following the MCD diet for 4 weeks, mice rapidly and consistently developed a steatohepatitis with steatosis, mixed inflammatory cell infiltration and hepatocellular necrosis which is in line with our previous report ...
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Death receptor and mitochondria-mediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water
... mitochondria-mediated apoptosis pathways, leading to liver ...mitochondria-mediated apoptosis pathways are orchestrated together, amplifying the apoptosis-inducing effect in rat ...
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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
... inhibited apoptosis and that hepatocytes isolated from Fas-deficient lymphoproliferative mice were resistant to GCDC-induced ...GCDC-induced hepatocyte apoptosis involves ligand-independent ...
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Hepatitis B Spliced Protein (HBSP) Suppresses Fas-Mediated Hepatocyte Apoptosis via Activation of PI3K/Akt Signaling
... of apoptosis, we generated HepG2 sublines stably transfected with empty vector pFlag or HBSP-expressing pHBSP and tested their sensitivity to agonistic anti-Fas antibody CH11, known to kill cells by the process of ...
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Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis
... in hepatocyte apoptosis in Acyl-Coenzye A oxidase 1-deficient mice during hepatocarcinogenesis ...and apoptosis than those from non-tumor livers ...
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Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF α induced hepatocyte apoptosis
... Excessive hepatocyte apoptosis is thought to lead to liver dysfunction and damage in a variety of liver dis- eases, and this process may occur during the initiation and/or progression of ...from ...
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<p>Phosphocreatine attenuates <em>Gynura segetum</em>-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway</p>
... Superoxide dismutase 2, mitochondrial (SOD2), a pri- mary antioxidant located in the mitochondrial matrix, sca- venges excess mitochondrial reactive oxygen species (ROS) to maintain mitochondrial function so the cell can ...
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The 55-kD Tumor Necrosis Factor Receptor and CD95 Independently Signal Murine Hepatocyte Apoptosis and Subsequent Liver Failure
... Materials and Methods: Using both mice and primary liver cell cultures deficient in either TNF-R I or functional CD95, the induction of apoptosis and hepatocyte death following activatio[r] ...
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The hepatocyte-specifically expressed lnc-HSER alleviates hepatic fibrosis by inhibiting hepatocyte apoptosis and epithelial-mesenchymal transition
... Many molecules and signalings have been documented to initiate HCs apoptosis and EMT in liver fibrosis, including TGFβ1, Notch and Hippo pathways. TGFβ1, a known pro-apoptotic cytokine in mature HCs, is capable of ...
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Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice
... Ablation of TNF signaling delays Fas-mediated hepatotoxicity. (A) Apoptosis of wild-type primary hepatocytes treated for 12 hours with the indicated doses of Jo-2 in the presence or absence of 1 ng/ml TNF. ...
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Kinase independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis
... induces apoptosis and necroptosis via kinase-dependent mechanisms and exhibits kinase-independent prosurvival and proinflammatory ...increased hepatocyte apoptosis and developed spontaneous chronic ...
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Massive hepatic apoptosis associated with TGF β1 activation after Fas ligand treatment of IGF binding protein 1–deficient mice
... massive hepatocyte apoptosis and caspase activation within 3 hours of Fas agonist treatment, which could be corrected by pretreatment with ...a hepatocyte apoptogen, was observed in IGFBP-1–deficient ...
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Hepatocyte specific inhibition of NF κB leads to apoptosis after TNF treatment, but not after partial hepatectomy
... to apoptosis (2, ...lethal hepatocyte apoptosis observed in p65 knockout mice can be rescued by crossing these mice into a TNF or TNFR1-null background (11, ...a hepatocyte progenitor cell ...
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s41421-017-0007-9.pdf
... macrophages are responsible for the hepatocyte apoptosis in DEN-treated WT mice and that the reduction in macrophages in the Cd24 − / − livers is responsible for the decreased hepatocyte[r] ...
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Important Role of P-Selectin for Leukocyte Recruitment, Hepatocellular Injury, and Apoptosis in Endotoxemic Mice
... induces hepatocyte apoptosis, which is character- ized by chromatin condensation, DNA fragmentation, and for- mation of intracellular apoptotic bodies (13, 18, ...of apoptosis in hepatocytes in vitro ...
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Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes
... dependent hepatocyte apoptosis in vitro in the virtual absence of Kupffer and stellate cells, and that LPS’s effect is additive to the apoptosis caused by bile acids or Fas ...
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Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation
... The hydrogen-rich UW solution group also showed less oxidative damage and hepatocyte apoptosis than the control group, and the expression of proinflammatory cytokines tended to be lower [r] ...
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Silica nanoparticles induce liver fibrosis via TGF-β<sub>1</sub>/Smad3 pathway in ICR mice
... hepatocytes’ apoptosis shown by morphological examination and TUNEL ...and hepatocyte apoptosis activated TGF-β 1 /Smad3 signaling pathway, and thus promoted the process of liver fibrosis induced by ...
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Original Article Prolonged warm ischemia aggravates hepatic mitochondria damage and apoptosis in DCD liver by regulating Ca 2+ /CaM/CaMKII signaling pathway
... chondrial apoptosis induced by ...cardiomyocyte apoptosis and necrosis by directly inducing mitochondrial apoptosis [29, ...inhibiting hepatocyte apoptosis ...mitochondrial ...
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