hepatocyte nuclear factor-1
A NOVEL MUTATION IN THE HEPATOCYTE NUCLEAR FACTOR-1 Α GENE AMONG MODY EGYPTIAN PATIENTS
... variants throughout the HNF1α gene, almost half of variants were silent mutations (8/23). Other 25 variants were detected in 14 different missense/frameshift mutations (14/25). Like in other studies (Pearson et al., ...
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Regulation of Hepatocyte Nuclear Factor 1 Activity by Wild-Type and Mutant Hepatitis B Virus X Proteins
... is identical to pET-HAX except that it contains the nt 1765 A-to-T and nt 1767 G-to-A double mutation. pCpHNF1-Luc contains four copies of the HNF-1 binding site derived from nt 1750 to 1779 of the core promoter ...
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Promoter-specific transactivation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1.
... Influence of the orientation and sequence of the HNF1 binding site on transcriptional activity from large surface antigen minimal promoter constructs containing single synthetic HNF1 bin[r] ...
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Novel variants in the hepatocyte nuclear factor 1 alpha gene in MODY and early onset NIDDM: Evidence for a mutational hotspot in exon 5
... MODY 1, HNF1- alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO- ...transcription factor genes with spe- cial reference to HNF1-alpha which are highly pe- netrant with ...
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Mesonephric adenocarcinoma of the cervix: a case report with a three-year follow-up, lung metastases, and next-generation sequencing analysis
... scription factor 1) is generally considered a biomarker for lung and thyroid carcinoma, it may be positive in ...(hepatocyte nuclear factor 1-beta), while considered a marker of ...
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Liraglutide downregulates hepatic LDL receptor and PCSK9 expression in HepG2 cells and db/db mice through a HNF-1a dependent mechanism
... Methods: At the cellular level, the expressions of PCSK9 and hepatocyte nuclear factor 1 alpha (HNF1α) protein in HepG2 cells stimulated by liraglutide was examined using Western blot. ...
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A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy
... alpha 1; EDS: Ehlers- danlos-syndrome; FBN1: Fibrillin 1 gene; GBM: Glomerular basement membrane; HNF1 β : Hepatocyte nuclear factor-1 β gene; LHX1: Homeobox transcription ...
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Cholestatic jaundice in infancy: struggling with many old and new phenotypes
... (hepatocyte nuclear factor-1-beta) gene muta- ...transcription factor, also plays a pivotal role in organogenesis during embryonic ...
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Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review
... for hepatocyte nuclear factor-1 beta (HNF-1 beta), but negative for CD30, making the diagnosis of AFP-producing clear cell type EOC with fetal gut differentiation in focal areas, FIGO ...
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Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening
... synthase 1; CDCFDA: 5(6)-carboxy-2’: 7’-dichlorofluorescein diacetate; DAPI: 4’:6-diamidino-2-phenylindole; DMET: drug metabolizing enzymes and transport; DMSO: dimethyl sulfoxide; DILI: drug-induced liver injury; ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... plus 1 to 1990 of the HBV genome (subtype ...plus 1 to 1990 of the HBV genome (subtype ...and nuclear hormone receptor (HNF4 and RXR␣-PPAR␣) binding sites are also ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... The hepatitis B virus (HBV) is a 42-nm enveloped particle possessing an internal 28-nm nucleocapsid (5, 14). The 3.2-kb partially double-stranded circular viral genome and the HBV polymerase are present within the ...
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor 4alpha/MODY1 gene
... LDL 1 HDL by the GPO-PAP method using the Ciba Corning 550 Express Clinical Chemistry Ana- lyzer (Boehringer ...LDL 1 HDL, were prepared by preparative ultracentrifugation using an Optima ta- bletop TLX ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Moreover, nuclear receptors exert diverse effects upon cell differentiation, morphogenesis, and carcinogenesis (2, 10, 12, ...(PPAR); hepatocyte nuclear factor-4 (HNF-4); chicken ovalbumin up- ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... With the greater realization of HNF-1α-inactivated hep- atic adenomas and HCCs, the scientific temptation to find its signaling transduction mechanism has become a natural drive. HNF-1α-regulated lipid and glucose me- ...
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Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma
... HNF4α is regarded as a key suppressor of hepatic carcinoma. To explore the mechanisms underlying the inhibitory effect of HNF4α on HCC, a cDNA microarray was performed to obtain gene expression profiles in Hep3B cells ...
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Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... Plasmids. The HBV (genotype D, GenBank accession number V01460.1) replication-competent plasmid pHBV1.3 was a generous gift from Guangxia Gao (Institute of Biophysics, Chinese Academy of Sciences, China). Plasmids ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... type 1 diabetes and some features of T2D, in addition to probable clinical diagnosis of MODY, genetic investigation of identified mutations could let to better ...
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Defective insulin secretion in hepatocyte nuclear factor 1alpha deficient mice
... Glucokinase and insulin mRNA levels. Since reduced ex- pression of the enzyme glucokinase could explain the decrease in insulin secretory responses to glucose present in the ho- mozygous mutant mice, experiments were ...
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Interactions between nuclear factors and the hepatitis B virus enhancer.
... These are the nuclear factor NF-1 binding site FP-I, the SV40 enhancer core element FP-II and FP-VI, the polyomavirus enhancer factor EF-C element FP-III, and the hepatocyte nuclear fact[r] ...
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