Hepatocyte nuclear factor 4
Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4
... receptor hepatocyte nuclear factor 4 (HNF-4), which binds to the NHRRE, dramatically stimulates apoAI gene expression in Caco-2 cells but not in HepG2 ...
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Suppression of Hepatocyte Nuclear Factor 4 Alpha by Long-Term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation
... To evaluate whether downregulation of HNF4α by HBV would affect the tumorigenicity of hepatoma cells in vivo, we investigated the tumor formation and growth in nude mice bearing HepAD38 or HepG2-X xenograft. HepAD38 ...
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Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... HNF4α mutations have been shown to play role in an autosomal dominant manner in families with an atypical form of T2D known as maturity onset diabetes of the young (MODY1) [20,21]. HNF4α's role in MODY origi- nates from ...
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Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
... Hepatic nuclear factors (HNFs) are a group of impor- tant host transcription factors that mainly reside in the liver and regulate numerous liver-expressed genes ...of hepatocyte nuclear factor ...
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A missense mutation in hepatocyte nuclear factor 4 alpha, resulting in a reduced transactivation activity, in human late onset non insulin dependent diabetes mellitus
... subjects is very similar to that seen in the prediabetic members of the MODY pedigree with the Q268X mutation in HNF-4 a as they have normal insulin secretion rates at lower glucose levels but lower than normal ...
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Mesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice
... key factor through which MSCs exert their anti-inflammatory effects ...inflammatory factor stimulation, nitrate was increased significantly in the con- ditioned ...
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Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma
... that affecting the uptake of nucleoside analogs. A study has reported that although the mRNA level of hENT1 in chronic lymphocytic leukemia cells is increased with the presence of interleukin 4 (IL-4), the ...
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Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults
... receptor hepatocyte nuclear factor 4-α (HNF4α) activates the promoters of multiple genes expressed in he- patocytes that play a role in lipoprotein metabolism ...transcription factor ...
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Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... Moreover, nuclear receptors exert diverse effects upon cell differentiation, morphogenesis, and carcinogenesis (2, 10, 12, ...(PPAR); hepatocyte nuclear factor-4 (HNF-4); chicken ...
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Functional interaction of nuclear factors EF-C, HNF-4, and RXR alpha with hepatitis B virus enhancer I.
... The nucleotide sequence of the GB element is similar to the sequences of binding sites of liver-enriched nuclear proteins HNF-4 hepatocyte nuclear factor 4 42 and RXRot retinoid X recept[r] ...
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Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
... Results: WGBS analyses in liver identified 969 hypermethylated and 871 hypomethylated differentially methyl‑ ated regions (DMRs) specifically identifying patients with WD, including 18 regions with genome‑wide ...
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Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left right asymmetry
... Figure 1. Targeted disruption of the mouse hfh-4 gene. (a) Wild-type hfh-4 allele (top) is composed of two exons (solid boxes) with the DNA- binding domain (shaded boxes) split between exons I and II. In ...
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor 4alpha/MODY1 gene
... the hepatocyte nuclear factor(HNF)-4 a /MODY1, glu- cokinase/MODY2, and HNF-1 a /MODY3 genes can cause this form of ...scription factor in the tissues in which it is expressed, in- ...
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Mechanisms of Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by Hepatocyte Nuclear Factor 3β
... Expression of truncated HNF3  polypeptides in mouse fi- broblasts. HNF3 has previously been shown to activate tran- scription from the HBV nucleocapsid promoter in reporter gene analysis (37) and to inhibit pregenomic ...
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Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6
... Regulation of HBsAg expression is crucial for the pathogenesis of HBV, as the envelope proteins is essential for the viral particle formation, infectivity, and immune response (2, 4). In the present study, an ...
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The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences
... tumorigenesis and aging. Interestingly, hepatic deficiency of SIRT1 leads to decreased HNF-1α/FXR signaling ac- tivity, which reduces hepatic bile acid excretion and raises the chances of liver damage [28]. One of the ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... studies, 4-week old HBV transgenic mice that lacked the rat HNF3 transgene were used as controls and compared with their rat HNF3-expressing HBV transgenic ...
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A NOVEL MUTATION IN THE HEPATOCYTE NUCLEAR FACTOR-1 Α GENE AMONG MODY EGYPTIAN PATIENTS
... The molecular spectrum of 13 HNF1α missense mutations were analysed according to two criteria. First, mutations were classified into two groups; Homozygous mutations 4/22 (I27L, E105G, E90V and S487N), and ...
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A review on hepatocyte nuclear factor-1beta and tumor
... peptidase 4 (DPP4), and osteopontin (SPP1) are most likely direct target genes, as they contain functional HNF1 binding sites in their promoter ...(Tissue factor pathway inhibitor 2) are proteases involved ...
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Hepatocyte nuclear factor 1α suppresses steatosis associated liver cancer by inhibiting PPARγ transcription
... increased hepatocyte proliferation as revealed by nuclear PCNA and Ki67 localization (Figure 3C and Supplemen- tal Figure ...a 4-fold increase in lip- id accumulation in liver, as assessed by ...
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