HER2 expression
Quantitative measurement of HER2 expression in breast cancers: comparison with ‘real world’ routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival
... local HER2 status and HERmark H2T results, we performed Kaplan-Meier analysis on four HER2-HERmark sub- groups: concordant negative (HER2 negative and H2T low), concordant positive (HER2 ...
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ER and HER2 expression are positively correlated in HER2 non overexpressing breast cancer
... and HER2 pathways might be an underlying cause of resistance, although the intrinsic biologic mechanism is poorly understood ...and HER2 expression have been described previously. ER and HER2 ...
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PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression
... that HER2 and HER3 could cooperatively regulate cancer cell growth and determine sensitivity to TAK-285, an orally bioavailable small molecule inhibitor of HER kinases ...plus HER2- targeted drugs such as ...
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Original Article Kif2a and HER2 expression in breast cancer tissue chip and their prognostic significance
... and HER2 expression in the breast cancer tumor and adjacent tissues of 102 patients to investigate the correlation of the two and the clinic pathological ...
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Effect of CD44st and HER2 expression on the postoperative prognosis of breast cancer patients
... abnormal expression of some CD44 isoforms are closely associated with axillary lymph node metastasis, cancer progression, and patients’ ...the expression of CD44st and HER2 in breast cancer and the ...
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ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer
... and HER2 RNA levels were negatively correlated as expected in HER2+ve (IHC 3+ and/or FISH- amplified) tumors (r = ...in HER2-ve tumors (ER+ve and ER-ve combined), a significant positive correlation ...
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HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status
... of HER2 protein expression or gene amplification is central to the management of breast cancer patients and is carried out according to standardized guidelines ...of HER2 expression [54], ...
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A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk
... For HER2 staining, cells were incubated with 2 mg ml 1 biotinylated Herceptin or Remicade as human IgG1 isotype control, for 20 min on ice, followed by washing and incubation with 2 mg ml 1 strepta- ...
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CYTOPLASMIC EXPRESSION OF HER2 IN GASTRIC ADENOCARCINOMA: AN UNUSUAL FINDING
... Nine out of 50 (18%) showed intestinal and 41/50 (82%) showed diffuse adenocarcinoma. 77.8% and 41.5% of intestinal and diffuse type adenocarcinoma were considered to be true positive for HER2 expression ...
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A BRCA1deficient like signature is enriched in breast cancer brain metastases and predicts DNA damage induced poly (ADP ribose) polymerase inhibitor sensitivity
... of HER2 expression in tumors of BRCA1 mutation carriers [24-26], and thus may reflect more upon the underlying biology of metastatic outgrowth in the brain rather than an aspect of HER2 ...19 ...
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HER2 reduces breast cancer radiosensitivity by activating focal adhesion kinase in vitro and in vivo
... if HER2 overexpression is associated with radiosensitivity of breast ...in HER2 expression by transducing HER2 cDNA or short hairpin RNA against ...that HER2 introduction in breast ...
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Original Article Impact of polysomy 17 on HER2 testing of invasive breast cancer patients
... define HER2-positive tumors as those with > 6 HER2 genes per nucleus or those with HER2/CEP17 (chromosome 17) ratio > ...of HER2 testing of invasive breast ...and HER2 gene status ...
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HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging.
... in HER2-positive cells and BC xenograft models when combined with trastuzumab (12, ...of HER2 expression and sensitivity to HER2-targeted drugs ...
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HER2-siRNA delivered by EGFR-specific single chain antibody inhibits NSCLC cell proliferation and tumor growth
... Because HER2 is frequently overexpressed in EGFR-positive NSCLC and to some extent accounts for resistance to EGFR-targeted therapy [31], we attempted to utilize scFv-9R to deliver HER2 siRNA (HER2si) and ...
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Original Article Human epidermal growth factor receptor 2 expression in urothelial carcinoma of the renal pelvis: correlation with clinicopathologic parameters
... Although HER2 expression in uro- thelial carcinoma of the urinary bladder has also been recently characterized, it has not been well studied in urothe- lial carcinoma of the renal ...between HER2 ...
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Original Article Quantitative RT-PCR assay of HER2 mRNA expression in formalin-fixed and paraffin-embedded breast cancer tissues
... erbB2) expression is a preparatory process to decide a treatment strategy for breast cancer ...have HER2 overexpression, and they usually show poor recovery ...of HER2 expression, immuno- ...
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Transphosphorylation of kinase dead HER3 and breast cancer progression: a new standpoint or an old concept revisited?
... of HER2-containing heterodimers (HER2 over- expression or overall low HER2 but high levels of the auto- crine/paracrine HER3 ligand heregulin), HER3 transphos- phorylation appears to be a ...
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Evaluation of Tobacco Use and Her 2 Receptor Expression in Breast Cancer in an Ethnically Diverse Inner City Population
... mented HER2 expression status, ER positivity and detailed smoking exposure ...documented HER2 status or who had BRCA mutation were excluded from final ...
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Original Article Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells
... Elevated expression of fatty acid synthase (FASN) and human epidermal growth factor receptor-2 (HER2) are observed in human osteosarcoma ...FASN expression and the activity of ...and HER2 as ...
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A class of genes in the HER2 regulon that is poised for transcription in breast cancer cell lines and expressed in human breast tumors
... ectopic HER2 overexpression in a breast cell culture model and compared these data to expression in breast cancer cell lines and breast cancer tissues with and without naturally amplified ...in HER2 ...
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