herpes simplex type 1
Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates
... Herpes simplex type 1 (HSV-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia (TG). Currently, two nonexclusive control mechanisms of HSV-1 ...
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... One unexpected result in these studies was that CJLAT caused severe corneal scarring in most of the infected rabbits. The corneal scarring was not apparent until after day 30 p.i., a time well after all primary infection ...
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Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.
... of herpes simplex virus (HSV) into mammalian cells is a multistep process beginning with an attachment step involving glycoproteins gC and ...HSV type 1 (HSV-1) attachment to cells, and ...
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Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire
... wild type HSV-1 and the ICP0 null- mutant in normal immortalized (hu- man embryonic lung fibroblasts; HEL) and cancer cells (epithelial HEp-2) depleted of STING, demon- strated that although STING was ...
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... Viral gene transcription in the region of the deletion. We next analyzed the transcription of the viral genome near the region that was deleted in the LAT null mutants. The 1.9-kb deletion in the LAT null mutants should ...
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Identification and typing of herpes simplex virus by enzyme immunoassay with monoclonal antibodies
... Typing of clinical herpes simplex virus isolates with mouse monoclonal antibodies to herpes simplex virus types 1 and 2: comparison with type-specific rabbit antisera and restriction end[r] ...
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Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B.
... Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: mutations affecting rate of virus entry and cell fusion.. The active inhibition of herpes simplex[r] ...
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Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats
... of herpes simplex keratitis, herpes simplex virus type 1 (HSV-1) infection begins in corneal epithelium cells and then progresses through the sensory nerve endings and ...
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Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report
... for herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), enteroviruses, and Epstein–Barr ...
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... TG DNA extraction. Rabbits were sacrificed, and their TG were removed, frozen in liquid nitrogen, and ground with a pestle. DNA was phenol extracted, ethanol precipitated, and solubilized in TE buffer (44). The TG DNA ...
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A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... Entry of wild-type 17 ⫹ at a low MOI of 0.1 resulted in greatly reduced beta-galactosidase activity (Fig. 4D). Despite different levels of reporter gene expression, 17 ⫹ was inhibited to a similar extent by MG132 ...
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The herpes simplex virus immediate-early protein, ICP4, is required to potentiate replication of human immunodeficiency virus in CD4+ lymphocytes.
... Deletion mutants in the gene encoding the herpes simplex virus type I immediate-early protein ICPO exhibit impaired growth in cell culture.. The herpes simplex virus type 1 alpha protein[r] ...
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Herpes simplex virus type 2 infection triggers AP 1 transcription activity through TLR4 signaling in genital epithelial cells
... against herpes viral DNA polymer- ases, and it could suppress viral productive cycle, but no or less influence on initial viral immediate-early (IE) or certain early (E) genes ...
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Pseudorabies Virus Glycoprotein M Inhibits Membrane Fusion
... immediate-early 1 promoter-enhancer of human cytomegalovirus were transfected into rabbit kidney cells, and the extent of cell fusion was quantitated 27 to 42 h after ...of herpes simplex virus ...
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Diagnosis of HSV Encephalitis in suspected Infants by using Real Time PCR at Gauhati Medical College and Hospital, Gauhati
... HIV, herpes simplex, herpes zoster (shingles), herpes B, polio, ...the herpes simplex virus, type 1 (HSV-1) and has a high rate of ...death. Herpes ...
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Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene
... In our search for novel inhibitors of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was discovered. ...
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Herpes simplex virus infects most cell types in vitro: clues to its success
... Herpes simplex viruses (HSV) are part of the alphaher- pesvirus subfamily of herpesviruses. There are two types of HSV: type-1 (HSV-1) and type-2 (HSV-2). These viruses are ...
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Characterization of herpes simplex virus type 2 transcription during latent infection of mouse trigeminal ganglia.
... RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.. Latent herpes simplex virus type 1 transcrip[r] ...
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Effect of Apolipoprotein E on the Cerebral Load of Latent Herpes Simplex Virus Type 1 DNA
... PFU of virus suspension as previously described (6). The mouse strain and the female gender were selected in order to compare the results with previously published data (6–8). The female gender was also used because this ...
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Amplification of Reiterated Sequences of Herpes Simplex Virus Type 1 (HSV 1) Genome To Discriminate between Clinical HSV 1 Isolates
... detected only three different alleles among 37 unrelated clin- ical HSV-1 isolates, which is not surprising since ReVII is located within a protein-coding region, making it a target for selective pressure. More ...
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