herpes simplex type-I virus
Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... In Fig. 4 and 5, the HSV DNA copy numbers per 100 cells for p.i. days 5 and 10 are expressed on the histograms, but they were not used in calculating the average copy number for the latency period between p.i. days 20 ...
5
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... PFU of 17syn⫹, 17-AHRI, 17-AH, 17-FA94, or 17-FA94R, groups of four mice were processed as above at days 6, 10, or 15 p.i., and 8-m sections were analyzed for TUNEL-positive cells. To facilitate interpretation of the ...
16
Amplification of Reiterated Sequences of Herpes Simplex Virus Type 1 (HSV 1) Genome To Discriminate between Clinical HSV 1 Isolates
... Herpes simplex virus type 1 (HSV-1)-related disease ranges from a localized, self-limiting illness to fatal disease in immunocompromised ...latent virus or reinfection with an exogenous ...
6
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... Construction of CJLAT. The plasmid p1658 contains two HSV-1 DNA restric- tion fragments. One restriction fragment (HpaI-EcoRV) corresponds to the region from 1800 to 161 nucleotides upstream of the LAT start site (LAT ...
12
Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire
... receptor type 5; CD4: cluster of differentiation 4; CD45: cluster of differentiation 45; CD63: cluster of differentiation 63; CD81: cluster of differentiation 81; CD86: cluster of differentiation 86; CD9: cluster ...
12
The Herpes Simplex Virus 2 Virion-Associated Ribonuclease vhs Interferes with Stress Granule Formation
... to type I interferon (IFN), resulting in impaired viral replication (47, ...the type I IFN signaling pathway is present and functional in HaCaT cells (49, 50), it is possible that a growth ...
13
Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.
... Truncated gC binds to cell surface HSPG. We demonstrated that truncated gC binds specifically to HSPG, employing three methods used previously to study the interaction of HSV viri- ons with the cell surface. First, HSV ...
13
Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene
... no virus growth was observed with any other fragment (Table ...bovine herpes virus has been shown to be a nonessential cytoplasmic protein ...
8
Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation in Mice
... Intracerebral inoculation of HSV-1. Three-week-old BALB/c female mice, obtained from the National Cancer Institute (Frederick, Md.), were anesthetized with a 250-l intraperitoneal (i.p.) injection of sodium ...
10
The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis
... HSV belongs to the family of neurotropic alphaherpesviruses, and their infection of neurons in the adult brain has been well described (7). However, some virus families which are not neu- rotropic in the adult ...
7
A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... Reduced capsid transport to the nucleus in the absence of tegument ICP0. To begin to address the impact of virion ICP0 on HSV entry, we analyzed HSVs bearing mutations in the ICP0 gene (Table 1). Viruses with ICP0 ...
9
The herpes simplex virus immediate-early protein, ICP4, is required to potentiate replication of human immunodeficiency virus in CD4+ lymphocytes.
... Deletion mutants in the gene encoding the herpes simplex virus type I immediate-early protein ICPO exhibit impaired growth in cell culture.. The herpes simplex virus type 1 alpha protein[r] ...
8
Effect of Apolipoprotein E on the Cerebral Load of Latent Herpes Simplex Virus Type 1 DNA
... Herpes simplex virus type 1 (HSV-1) is neurotropic and enters a latent state lasting the lifetime of the ...the virus in the nervous system than the wild-type mice, while the ...
5
Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report
... We then hypothesized an astrovirus-related CNS in- fection and tested the initially obtained CSF sample for the virus. Sanger sequencing revealed a classic genotype HAstV-1 with the same nucleotide sequence in ...
5
Herpes virus seroepidemiology in the adult Swedish population
... We report seroprevalence estimates of five common human herpes viruses in the general adult population in Sweden. The most frequent species, VZV and HHV6, both showed more than 97% prevalence. Studies from USA ...
6
Identification and typing of herpes simplex virus by enzyme immunoassay with monoclonal antibodies
... Typing of clinical herpes simplex virus isolates with mouse monoclonal antibodies to herpes simplex virus types 1 and 2: comparison with type-specific rabbit antisera and restriction end[r] ...
5
Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B.
... Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: mutations affecting rate of virus entry and cell fusion.. The active inhibition of herpes simplex[r] ...
11
Herpes simplex virus infects most cell types in vitro: clues to its success
... HSV-2: Herpes simplex virus type-1 and type-2; HveA: herpesvirus entry mediator A; HveB: herpesvirus entry mediator B; HveC: herpesvirus entry mediator C; HVEM: Herpesvirus entry ...
11
Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs
... Histone deacetylase inhibitors (HDIs) are a class of com- pounds that appear to benefit HSV oncolysis, possibly via suppression of innate immune responses. Histone deacety- lases (HDACs) have pleiotropic effects on cells ...
18
Pseudorabies Virus Glycoprotein gK Is a Virion Structural Component Involved in Virus Release but Is Not Required for Entry
... varicella-zoster virus, egress of virions from infected cells has been postulated to involve primary envelopment at the inner nuclear mem- brane, loss of primary envelope by fusion at the outer lamella of the ...
10