Herpes simplex virus type 1/2
Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene
... The level of similarity between HSV-1 UL6 (strain Patton) and its HCMV homologue UL104 (strain AD169) is 21% (data not shown). This might indicate that the actual function of these proteins is conserved but that ...
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Herpes simplex virus infects most cell types in vitro: clues to its success
... HSV-2: Herpes simplex virus type-1 and type-2; HveA: herpesvirus entry mediator A; HveB: herpesvirus entry mediator B; HveC: herpesvirus entry mediator C; HVEM: ...
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... wild-type virus and marker-rescued dLAT2903R is ...detected 2-kb LAT (solid rectangle) appears to be an intron derived by splicing of the primary LAT ...This virus is missing key promoter ...
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Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency.
... 17Syn 1 and at least 80% of the eyes of these rabbits undergo ocular reactivation from 20 to 360 days fol- lowing ...of virus from eye swabs and/or recurrent corneal epithelial lesions (1–3, 8, ...
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Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D.
... A region common to herpes simplex virus type 1 and 2 gD amino acid residues 11 to 19 and two sites specific for herpes simplex virus type 2 gD one determined by proline at position 7, th[r] ...
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Amplification of Reiterated Sequences of Herpes Simplex Virus Type 1 (HSV 1) Genome To Discriminate between Clinical HSV 1 Isolates
... of 1 M, and each deoxynucleoside triphosphate, including equimolar amounts of dGTP and 7-deaza-2⬘-dGTP (Boehringer Mannheim, Mannheim, Germany), at a concentration of 200 ...Table 1), and primer ...
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Characterization of herpes simplex virus type 2 transcription during latent infection of mouse trigeminal ganglia.
... RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice.. Latent herpes simplex virus type 1 transcrip[r] ...
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Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire
... the virus expresses a subset of immediate- early, early and latent genes, including viral homologues of the anti-apoptotic Bcl-2 family members, the viral interleukin (vIL-10) and BZLF1 that secure the ...
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Effect of Apolipoprotein E on the Cerebral Load of Latent Herpes Simplex Virus Type 1 DNA
... of virus suspension as previously described ...subsides 2 weeks after inoc- ulation and all HSV-1 present is in a latent state by 4 weeks after inoculation (33), the mice were sacrificed at 37 days ...
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Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation in Mice
... With the recent findings of HSV DNA in the CNS of pa- tients dying without encephalitis (2, 43, 68), it became impor- tant to determine whether i.c. injection of G207 might lead to reactivation of or recombination ...
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Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report
... for herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), enteroviruses, and Epstein–Barr ...
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A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... Reduced capsid transport to the nucleus in the absence of tegument ICP0. To begin to address the impact of virion ICP0 on HSV entry, we analyzed HSVs bearing mutations in the ICP0 gene (Table 1). Viruses with ICP0 ...
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Identification and typing of herpes simplex virus by enzyme immunoassay with monoclonal antibodies
... Typing of clinical herpes simplex virus isolates with mouse monoclonal antibodies to herpes simplex virus types 1 and 2: comparison with type-specific rabbit antisera and restriction end[r] ...
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Herpes simplex virus type 2 infection triggers AP 1 transcription activity through TLR4 signaling in genital epithelial cells
... that herpes simplex virus could trigger cellular PPRs to modulate innate immune ...of virus-induced TLR4 expres- sion up-regulation was ...
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The herpes simplex virus immediate-early protein, ICP4, is required to potentiate replication of human immunodeficiency virus in CD4+ lymphocytes.
... Deletion mutants in the gene encoding the herpes simplex virus type I immediate-early protein ICPO exhibit impaired growth in cell culture.. The herpes simplex virus type 1 alpha protein[r] ...
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Establishment of a novel therapeutic vector targeting the trigeminal ganglion in rats
... experiments demonstrated the safety of rdHSV-IFN γ . To evaluate the targeting effectiveness of rdHSV-IFN γ , we isolated trigeminal ganglia from immunized rats and assayed IFN γ expression on days 1, 7, 14, and ...
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Syncytium-inducing mutations localize to two discrete regions within the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B.
... Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: mutations affecting rate of virus entry and cell fusion.. The active inhibition of herpes simplex[r] ...
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Pattern of Sexually Transmitted Infections among Men having Sex with Men - A Prospective Study.
... Among these, again viral infection(33.4%) topped the list followed by the bacterial STIs(24.4%).The following pattern is seen, primary syphilis(2.2%), secondary syphilis(6.7%), latent Syphilis(6.7%), gonorrhea(2.2%), non ...
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Herpes Virus And Periodontal Disease
... Herpes virus infections generally involve a mild or asymptomatic primary phase followed by an asymptomatic latent phase interrupted sporadically by periods of ...activation. Herpes virus ...
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Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.
... with 1% bovine serum albumin (BSA) (fraction V; Boehringer Mannheim) and 1% chicken ovalbumin (Sigma) in PBS (blocking buffer) for 30 min at room temperature ...After 1 h of incubation, plates were ...
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