Herpesvirus 8
Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Replication and Transcription Factor Activates the K9 (vIRF) Gene through Two Distinct cis Elements by a Non-DNA-Binding Mechanism
... Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8), is found in Kaposi’s sarcoma (7). The genomic sequence of KSHV has high similarity to that of Epstein-Barr virus (EBV), ...
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Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran
... human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub- Saharan Africa and Mediterranean ...
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Pregnancy and Human Herpesvirus 8 Reactivation in Human Immunodeficiency Virus Type 1 Infected Women
... In conclusion, although this study was limited to a relatively low number of pregnant women, it demonstrates that, like other herpesviruses, HHV-8 may be reactivated during preg- nancy in HIV-1-infected women. The ...
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Intracellular Localization Map of Human Herpesvirus 8 Proteins
... Human herpesvirus 8 (HHV-8) is the etiological agent of Kaposi’s sarcoma. We present a localization map of 85 HHV-8-encoded proteins in mammalian cells. Viral open reading frames were cloned ...
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Human Herpesvirus 8 (HHV-8)-Encoded Cytokines Induce Expression of and Autocrine Signaling by Vascular Endothelial Growth Factor (VEGF) in HHV-8-Infected Primary-Effusion Lymphoma Cell Lines and Mediate VEGF-Independent Antiapoptotic Effects
... Human herpesvirus 8 (HHV-8) is associated with Kaposi’s sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman’s ...references 8 and 28). In PEL, expres- sion of several ...
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K-bZIP of Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 (KSHV/HHV-8) Binds KSHV/HHV-8 Rta and Represses Rta-Mediated Transactivation
... sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) gene expression bears resemblance to that of Epstein-Barr virus (EBV), but with interesting ...
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Three-Dimensional Structure of the Human Herpesvirus 8 Capsid
... Human herpesvirus 8 (HHV-8), or Kaposi’s sarcoma-associated herpesvirus, is a gammaherpesvirus impli- cated in all forms of Kaposi’s sarcoma and certain ...
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Characterization of Human Herpesvirus 8 ORF59 Protein (PF-8) and Mapping of the Processivity and Viral DNA Polymerase-Interacting Domains
... Human herpesvirus 8 (HHV-8), also known as KS-associated herpesvirus, is implicated in the pathogenesis of KS (reviewed in references 17 and ...(1, 8, 9, 15, 23, 36, 51) and in ...
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Multiple human herpesvirus-8 infection
... In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus–8 (HHV-8) subgenomic DNA, amplified from oral and blood samples ...
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Serodiagnosis of Human Herpesvirus 8 in Women with Breast Cancer
... Human herpesvirus 8 (HHV-8) is a common virus in the Mediterranean region. It has been linked to a number of malignancies, and it is believed to be the causative agent in certain cases. The aim of ...
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Investigation of the Multimerization Region of the Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Protein K-bZIP: the Proposed Leucine Zipper Region Encodes a Multimerization Domain with an Unusual Structure
... The K8 gene of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr virus. The protein products of K8 and BZLF1, ...
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Lipid Rafts of Primary Endothelial Cells Are Essential for Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8-Induced Phosphatidylinositol 3-Kinase and RhoA-GTPases Critical for Microtubule Dynamics and Nuclear Delivery of Viral DNA but Dispensable for Binding and Entry
... sarcoma-associated herpesvirus (KSHV) (human herpesvirus 8 [HHV-8]) induces the host cell’s preexisting FAK, Src, phosphatidylinositol 3-kinase (PI3-K), Rho-GTPases, Diaphanous-2 (Dia-2), ...
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Human Herpesvirus 8 Induces Polyfunctional B Lymphocytes That Drive Kaposi’s Sarcoma
... human herpesvirus 8 (HHV-8; Kaposi’s sarcoma-associated herpesvirus) that are not fully transformed but are instead driven to excess proliferation by inflammatory and angiogenic ...
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Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
... Human herpesvirus 8 (HHV-8; also known as Kaposi’s sarcoma-associated herpesvirus) is the causative agent of Kaposi’s sarcoma and certain B-cell ...
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Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma.
... Epidemiological studies indicated that Kaposi’s sarcoma (KS) has an infectious etiology (5), and this led to the identi- fication of sequences of a new gammaherpesvirus in KS tumor tissue (9), termed Kaposi’s ...
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The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
... sarcoma-associated herpesvirus (KSHV) (also called human herpesvirus 8) has been isolated and ...of herpesvirus saimiri, the most similar virus by phylogenetic ...
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Role of ORF74-Encoded Viral G Protein-Coupled Receptor in Human Herpesvirus 8 Lytic Replication
... HHV- 8-related gamma-2-herpesviruses, the vGPCRs are fairly highly diverged structurally and have unique functional prop- erties (19, 21, ...in herpesvirus repli- cation has been investigated in other viral ...
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New approaches to the treatment of human herpesvirus 8-associated disease.
... Human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus or KSHV) is the etiologic agent of Kaposi sarcoma (KS) and primary effusion lymphoma (PEL), as well as many ...
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Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons
... Human herpesvirus-8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), establishes life- long latent infection, punctuated with periods of lytic replication at mucosal sites ...
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Transcriptional Regulation of the Interleukin-6 Gene of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)
... Human herpesvirus 8 (HHV-8; Kaposi’s sarcoma-associated herpesvirus is linked to Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD), all of ...
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