HIF -1
Prognostic value of plasma levels of HIF-1 aand PGC-1a in breast cancer
... and HIF-1α has been studied extensively and it seems that in angiogenesis, PGC-1α stimulates VEGF independently of ...induce HIF-1α- ...activates HIF [38, ...and HIF-1: ERRα and PGC-1β ...
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The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
... induce HIF-1 α in JHH-4 or solely in a transient way in ...OSM-induced HIF-1 α pro- tein levels are similar to those induced by hypoxia, the impact on PDK1 expression was less ...OSM-induced ...
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Circulating stem cells, HIF 1, and SDF 1 in septic abdominal surgical patients: randomized controlled study protocol
... Background: Sepsis caused by complicated intra-abdominal infection is associated with high mortality. Loss of endothelial barrier integrity, inflammation, and impaired cellular oxygen have been shown to be primary ...
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ERβ regulation of NF- B activation in prostate cancer is mediated by HIF-1
... by HIF-1. Loss of ERβ or hypoxia stabilizes HIF-1α, which we found to be a direct driver of IKKβ transcription through a hypoxia response element present in the promoter of the IKKβ ...
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Effect of L- Arginin on Placental Hipoxia Inducible Factor -1-Alpha (HIF-1-A) Expression at Preeclampsia Mice Models
... blood. HIF-1 is an important element in the regulation of transcription of various genes that appear in hypoxic conditions (Wantania et ...1α). HIF-1α or HIF-1-A play an important role ...
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Temperature regulates hypoxia inducible factor 1 (HIF 1) in a poikilothermic vertebrate, crucian carp (Carassius carassius)
... that HIF-1 also has important roles in metabolic control of tissue function at high oxygen ...Although HIF-1 ␣ amounts in mammalian cells upon normoxia are generally less than the detection ...
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ARNT is a potential direct HIF-1 target gene in human Hep3B hepatocellular carcinoma cells
... affinity HIF binding sites might also be occupied by HIF-1 dur- ing prolonged hypoxia ...between HIF-binding sites and distant gene promoters ...define HIF target genes and contribute ...
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DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas
... of HIF-1α is sufficient to enhance DEC2 protein levels, and inhibiting prolyl hydroxylase activity by DFX under normoxic condition also enhanced DEC2 levels (Figure ...predicted HIF-1 binding site at ...
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HIF-1 and TAZ serve as reciprocal co-activators in human breast cancer cells
... that HIF-1 stimulates the expression and activity of TAZ, which is a transcriptional effector of the Hippo signaling pathway, by increasing TAZ synthesis and nuclear ...between HIF-1α and TAZ has ...
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<p>ASAP3 is a downstream target of HIF-1α and is critical for progression of lung adenocarcinoma</p>
... and HIF-1 α in A549 cells transfected with pLKO.1-ASAP3, pLKO.1-HIF1 α or the combination of ...against HIF-1α and ASAP3 in orthotopic tumors in nude ...
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Expression of Iron Regulatory Protein 1 Is Regulated not only by HIF-1 but also pCREB under Hypoxia
... Unless otherwise stated, all chemicals including β-actin were obtained from the Sigma Chemical Company, St. Louis, MO, USA. Primary anti-rabbit IRP1 antibody was bought from Abcam, Cambridge, UK; anti-rabbit pCREB ...
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The association of HIF-1α expression with clinicopathological significance in prostate cancer: a meta-analysis
... or HIF or HIF-1 or HIF-1 α OR HIF-1A”) and (“prostatic cancer” or “prostate cancer” or “prostatic carcinoma” or “prostate carcinoma” or ...
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Adaptation to HIF 1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas
... than HIF- 1 upregulating transcription or inducing a covalent post-translational modification of one or more glycolytic ...Table 1 Differentially expressed glycolytic and related proteins in ...
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Hypoxia promotes fibrogenesis in vivo via HIF 1 stimulation of epithelial to mesenchymal transition
... epithelial Hif-1α is fibrogenic in a chronic renal injury model and thus exerts a disease-promoting ...that HIF-1 may have a context- and/or cell type–specific biological role with regard to renal ...
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A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia
... We next analyzed the APL-specific subnetwork across different FAB subtypes to study its behavior following progressive differentiation states of leukemic cells. In Figure 2B, transcripts are depicted as empty circles if ...
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Studies of hypoxia response and regulation of hypoxia inducible factor HIF 1 in Caenorhabditis elegans
... However, the expression levels of the HIF-1-dependent reporter and HIF-1 target gene K10H10.2 are significantly higher in rhy-1 mutants than in vhl-1 mutants Chapter 3 Figure 5A & C, ind[r] ...
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The effect of HIF-1α and PKM1 expression on acquisition of chemoresistance
... Western blotting results revealed that the expression level of HIF-1 α in rMKN45-PTX was significantly higher than that in MKN45 as shown in Figure 4. rMKN45-PTX cells showed upregulation of the ...
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HIF 1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
... lucomutase 1 (PGM1), UDP-glucose pyrophosphorylase (UGP2), glycogen synthase (GYS1), glycogen branching enzyme (GBE1), as well as the gene encoding PPP1R3C, which activates GYS1 and inhibits liver-type glycogen ...
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Short-wave enhances mesenchymal stem cell recruitment in fracture healing by increasing HIF-1 in callus
... hypoxia. HIF protein, es- pecially HIF-1α, has been associated with MSC migration and differentiation ...regulator, HIF-1 can regulate the expression of multiple cytokines, such as stromal ...
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The role of HIF-1α in chemo-/radioresistant tumors
... that HIF-1 α inhibited the chemo-/ radiotherapy-induced apoptosis of tumor cells through the promotion of antiapoptotic proteins (STAT3 and TCF4; Table ...that HIF-1 α -mediated suppression of ...
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