HIF-1alpha
Weak HIF 1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma
... high HIF-1alpha expression and good prognosis remains ...studies, HIF-1alpha associated commonly with other hypoxia-related markers, such as CAIX, suggesting hypoxia-dependent ...
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Original Article Exposure to cigarette smoke alters AgNOR number and HIF-1alpha expression in colorectal tubular adenocarcinoma in rats
... in HIF-1alpha hypoxia marker expression and AgNOR count, as well as the relationship between these two markers and tubular adenocarcinoma differentiation level in an experi- mental colorectal cancer ...for ...
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Expression and regulation of HIF 1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor
... pro-inflammatory HIF-1 alpha expression in macrophages to identify possible new intervention ...on HIF-1 alpha expression and downstream production of pro-angiogenic factors in ...of HIF-1 alpha, ...
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Quantification of the Expression of HIF 1alpha by Real Time PCR in Rat Hepatocytes Cultures Invaded by Shigella flexneri under Normoxic and Hypoxic Conditions
... factor HIF-1alpha that may have a cell protective ...and HIF-1alpha on bacterial infection, studied in this work, is ...factor- 1alpha (HIF-1alpha) is a transcription ...
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The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells
... by HIF- 1alpha was CLIC2. The largest groups upregulated by HIF- 1alpha in NCI-H446 cell were genes associated with trans- port and the metabolic ...of HIF-1alpha such as VEGF, ...
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Halbgewachs, Birgit (2010): Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) als prometastatischer Faktor: Identifizierung von Hypoxia-inducible Factor-1alpha (HIF-1alpha) und Neutrophilen Granulozyten als wichtige Mediatoren. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... der HIF-1α- und CAIX-Expression, obwohl auch hier mehr als dop- pelt so viele Neutrophile Granulozyten nachweisbar waren wie in ...an HIF-1α in den Tumorzellen ...von HIF-1α wäre beispielsweise ...
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Original Article Anti-angiogenic effect of rapamycin in mouse oxygen-induced retinopathy is mediated through suppression of HIF-1alpha/VEGF pathway
... As described, cell preparation was treated with RAPA at different concentrations. HUVECs and the retinas in the experimental groups were col- lected and lysed in RIPA buffer. Bradford meth- od was used to measure the ...
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Original Article Increased HIF-1alpha expression in tumor cells and lymphocytes of tumor microenvironments predicts unfavorable survival in esophageal squamous cell carcinoma patients
... of HIF-1α in esophageal squamous cell carcinoma (ESCC) is still ...the HIF-1α expression by immunochemistry in tumor specimens from 136 resected ESCC; in the current study, the HIF-1α expression in ...
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Original Article Hypoxia-inducible factor (HIF)-1alpha knockout accelerates intervertebral disc degeneration in mice
... Abstract: Introduction: The abnormality of nucleus pulposus (NP) plays a critical role in intervertebral disc (IVD) de- generation, in which NP cells show apoptosis and fibrosis, leading to the ability of the disc to ...
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Novel stromal cell signalling systems in oesophageal cancer
... "Expression of hypoxia-inducible factor HIF-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma."[r] ...
206
Original Article Hypoxia-induced up-regulation of Aquaporin-1 in Rat Schwann cells via the MAPK pathway
... AQP1 expression alterations affect morphology and water trans- port in Schwann cells and hypoxia-induced up- regulation of AQP1 occurs in a HIF-1alpha- dependent manner.. Hypoxia-induced[r] ...
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Enrichment of CD44 in basal-type breast cancer correlates with EMT, cancer stem cell gene profile, and prognosis
... Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1alpha in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohist[r] ...
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Vasa vasorum anti-angiogenesis through H<sub>2</sub>O<sub>2</sub>, HIF-1α, NF-κB, and iNOS inhibition by mangosteen pericarp ethanolic extract (<em>Garcinia mangostana</em> Linn) in hypercholesterol-diet-given <em>Rattus norvegicus</em> Wistar strain
... , HIF-1α, NF-κB, and iNOS inhibition in rats given a hypercholesterol ...and HIF-1α, which were measured by using immunofluorescence double staining and observed with a confocal laser scanning microscope in ...
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The effect of HIF-1α and PKM1 expression on acquisition of chemoresistance
... Results: The resistance index was 6.1 by determining as the ratio of the 50% growth inhibition (IC 50 ) of rMKN45-PTX/IC 50 of MKN45. Expression of nuclear factor kappa B and HIF-1α was increased in rMKN45-PTX ...
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Hypoxia inducible factor–2 (HIF 2) regulates hepatic erythropoietin in vivo
... of HIF-2–mediated EPO expres- sion in ...of HIF-1α and HIF-2α and the transcriptional activation of EPO and PGK1 (Figure 7, A and ...was HIF-2α dependent and HIF-1α inde- pendent as ...
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LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118
... of HIF-1α, HIF-2α, and HIF-1β in hCMEC/D3 cells, with or without induction by DMOG ...of HIF-1β, but not HIF-1α and HIF-2α ...of HIF-1β in regulation of the HIF ...
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Original Article Anti-angiogenic and anti-proliferative effects of inhibition of HIF-1α by p-HIF-1α RNAi in colorectal cancer
... of HIF- 1α and VEGF is correlated with a more advanced tumour stage and a poorer prognosis in patients with ...that HIF-1α regulates tumour angiogenesis through VEGF induction in primary and meta- static ...
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<p>ASAP3 is a downstream target of HIF-1α and is critical for progression of lung adenocarcinoma</p>
... Figure 4 (A and B) Western blotting of ASAP3 and HIF-1 α in A549 cells transfected with pLKO.1-ASAP3, pLKO.1-HIF1 α or the combination of pLKO.1-HIF1 α + pcDNA3.1-ASAP3. (C) Representative immunohistochemical ...
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HIF 1 and HIF 2: working alone or together in hypoxia?
... of HIF-2α rather than ...linking HIF-2α with Epo regulation; a previous study using siRNA to suppress the expression of HIF-α isoforms specifically in Hep3B cells reported a dominant role for ...
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<p>Long Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer</p>
... that HIF-1 α can also positively regulate CASC9 expression, suggesting a positive feedback loop existed between CASC9 and HIF-1 α ...that HIF-1 α was markedly overexpressed in lung cancer tissues, ...
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