High affinity
High affinity esterification of eicosanoid precursor fatty acids by platelets
... exhibited high affinity, relatively rapid incorporation into platelet phospholipids at pH ...apparent affinity of the synthetase for fatty acid is much ...
8
Regulation of high affinity IgE receptor mediated mast cell activation by murine low affinity IgG receptors
... Allergic symptoms result from the release of granular and lipidic mediators and of cytokines by inflammatory cells. The whole process is initiated by the aggregation of mast cell and basophil high-affinity ...
10
Multiple high affinity binding sites for
... of high-affinity 5-HT binding sites in the Arctic charr brain, all showing high affinities for the endogenous ligand but differing affinities for the synthetic ligands, best illustrated by the ...
7
The high affinity calcium binding sites in fibrinogen
... a high a f f i n i t y fo r o th e r c a tio n s , p a r tic u la r ly those o f a lk a lin e e a rth m etals such as magnesium, which is a s e rio u s disadvantage in fib rin o g e n s tu d ie s as b u ffe rs c ...
172
Virtual screening for high affinity guests for synthetic supramolecular receptors
... In the GOLD docking process, a search of different guest conformations is performed, and it is possible to nd a conformation of the open-chain ketone that ts as well into the cage as the cyclic ketone. The ...
6
Virtual screening for high affinity guests for synthetic supramolecular receptors
... In the GOLD docking process, a search of different guest conformations is performed, and it is possible to nd a conformation of the open-chain ketone that ts as well into the cage as the cyclic ketone. The ...
5
High Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa
... ABSTRACT Histamine is a key biological signaling molecule. It acts as a neu- rotransmitter in the central and peripheral nervous systems and coordinates lo- cal inflammatory responses by modulating the activity of ...
15
Virtual screening for high affinity guests for synthetic supramolecular receptors
... describes the torsional strain, in other words the enthalpy penalty associated with putting a guest into a high energy conformation. However, the scoring function does not account for the entropy penalty of ...
5
Direct selection for mutants with increased K+ transport in Saccharomyces cerevisiae.
... Saccharomyces cerevisiae cells containing a deletion of T R K l , the gene encoding the high affinity potassium transporter, retain only low affinity uptake of this ion[r] ...
8
Chronic caffeine ingestion sensitizes the A1 adenosine receptor adenylate cyclase system in rat cerebral cortex
... two affinity states in control rat cerebral cortex membranes with a high affinity dissociation constant (KH) of ...low affinity dissociation constant (KL) of ...the high affinity ...
7
Characterization of recombinant β-fructofuranosidase from Bifidobacterium adolescentisG1
... showed high affinity to low molecular fructans (Raftilose, DP < 5) compared to low or high polymerized inulin (Raftiline LS or HP) or sucrose ...
10
Structural Insight into the Binding Interactions of Native and Mutant Structures of Dihydrofolate Reductases
... ABSTRACT: Dihydrofolate reductase (DHFR) is an important enzyme in the cell and is the target for antifolate drugs such as methotrexate, pyrimethamine and trimethoprim. In this study, we compared the binding interactions ...
5
Hemoglobin–oxygen affinity in high altitude vertebrates: is there evidence for an adaptive trend?
... indigenous high-altitude populations. In yaks, high-affinity fetal Hb isoforms are expressed at high levels in one-month-old calves (Weber et ...
14
Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant.
... Kinetic analysis showed that the snf3 mutants lack high-affinity glucose uptake, but exhibit normal low-affinity uptake (BISON et al. The defect in high-affinity transport[r] ...
8
Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue
... pound’s affinity for the channel. A fair agreement between affinity and correction was observed; a high affinity analogue (DA-1) completely restored mature hERG protein levels in the presence ...
13
High vaccination efficiency of low affinity epitopes in antitumor immunotherapy
... with high-affin- ity tumor epitopes in tumor immunotherapy. High- avidity CTLs specific for high-affinity dominant tumor epitopes have been recruited in some ...instance, high-avidity ...
10
Dynamic regulation of leukocyte beta adrenergic receptor agonist interactions by physiological changes in circulating catecholamines
... a high affinity from a mean (+/- SEM) of 42 +/- 5 to 24 +/- 2% (P less than ...a high affinity were seen after infusion of ...and affinity for agonists, probably by the effect of ...
8
Core-Binding Factor Influences the Disease Specificity of Moloney Murine Leukemia Virus
... containing high-affinity core sites (Mo:Soule and Mo: SL3-3) that conferred relatively high transcriptional activity in T cells induced disease with significantly shorter latent periods than viruses ...
13
Binding of Typical and Atypical Antipsychotic Agents.pdf
... Although 5-HT6 or 5-HT receptor affinity alone does not prediCt whether or not a drug will have atypical antipsychoc actMty, the relatively high affinity of the 5-HT receptor for several[r] ...
8
Two E2 binding sites alone are sufficient to function as the minimal origin of replication of human papillomavirus type 18 DNA.
... two high-affinity E2BS, while pori117* contains one low-affinity and one high-affinity site), these results suggest that replication of HPV-18 ori DNA by the heterologous HPV-1a E1 and ...
5