High Dose Methotrexate Treatment
A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity
... as high as 40% in the elderly patient (older than 65 years) ...of methotrexate; however, its toxicity remained unchanged in elderly but significantly increased in the patient with reduced renal function ...
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Prevalence of Leukoencephalopathy in Children Treated for Acute Lymphoblastic Leukemia with High Dose Methotrexate
... Consecutive patients who were at least 1 year of age who were enrolled on our institutional ALL treatment protocol between July 30, 1998, and August 30, 1999, were eligible for this study. The diagnosis of ALL was ...
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High Dose Methotrexate and Leucovorin Rescue Therapy in Childhood Malignancies: Experience in Resource-Limited Country
... of high dose methotrexate (HDMTX) repeated courses in five groups of pediatric patients seven patients had Pre-B ALL and were treated with four courses of HD-MTX (total of 28 courses); two patients ...
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The Effects of Low Dose Methotrexate on Metabolism in Primary Human PBMCs
... both high and low concentrations. It is generally accepted that low-dose MTX has no cytotoxic effect in unactivated primary cells and non-mitogen-activated primary cells have also shown little ...
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Clinical Reasoning: Progressive visuospatial problems in a 71-year-old man
... Methotrexate does not typically cross the blood– brain barrier in high concentration. However, it is possible that autoimmune disorders and a systemic inflammatory response, as was present here, lead to ...
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Neoadjuvant multidrug chemotherapy including High Dose Methotrexate modifies VEGF expression in Osteosarcoma: an immunohistochemical analysis
... combined treatment consisting of neoadjuvant chemotherapy, wide tumor excision, adjuvant chemotherapy and, if necessary, resec- tion of ...customize treatment pro- tocols [7], the possibility of identifying ...
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High Dose Methotrexate in Treatment of Acute Lymphoblastic Leukemia: Toxicity Profile and Comparison of Tolerability Between Two Dosage Schedules.
... significantly elevated plasma MTX concentrations Variations in serum Creatinine was further studied in both the groups, by taking the absolute values in each consolidation cycle .Elimination delay in Methotrexate ...
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Glucarpidase to combat toxic levels of methotrexate in patients
... Like methotrexate (and unlike carboxypeptidase G2) it is taken up and metabolized by ...loading dose followed by a continuous 18-hour intravenous infusion of methotrexate designed to maintain a ...
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Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo A rationale for high dose methotrexate
... logic measurement translated into greater cytotoxicity, the present investigation was undertaken to determine whether higher MTXPG concentrations in the target tissue are associ- ated with greater antileukemic effects in ...
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EFFECT OF HIGH DOSE METHOTREXATE AND DELAYED ELIMINATION ON MYELOTOXICITY PROGRESSION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
... the treatment of children with ALL. The use of high dose methotrexate, sometimes in combination with 6- mercaptopurine (6-MP) has significantly contributed to cure children ...
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Medium and High-Dose Methotrexate-Induced Toxicity in Children with Acute Lymphoblastic Leukemia
... When MTX administration ended, its serum level was measured 24, 48 and 72 hours later. Patients’ hydration and urine alkalization as well as plasma creatinine were checked in first and second days and patients were ...
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Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
... In this case report we demonstrate the successful the- rapy of a patient with cIVL, i.e. intravascular lymphoma limited to the CNS. The few reports available on the treatment of this medical condition are ...
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Original Article A survival analysis and treatment outcomes of 131 cases of osteosarcoma treated with high-dose methotrexate multidrug chemotherapy 1
... to high physiological AKP level in children patients, whose bone development is ...and high costs, BALP as an osteosarcoma pre- dictor is not widely ...
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The effect of intravenous hydration strategy on plasma methotrexate clearance during intravenous high-dose methotrexate administration in pediatric oncology patients
... plasma methotrexate level-monitoring guidelines to optimize the dose and frequency of administered ...cancer treatment; however, only a few of these have specifically looked at the safety of this ...
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<p>Identifying risk factors for high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia</p>
... the dose of CF to decrease the MTX-related toxicities in the original treatment protocol of HD-MTX in all children with ...HD-MTX treatment in children with ALL showed relationships between poly- ...
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Neurocognitive Side Effects of High Dose Methotrexate and Cranial Radiotherapy in Acute Lymphoblastic Leukemia Patients on Bfm 86 Protocol Treatment.
... of treatment for childhood ALL in a group of patients who received dexamethasone during the intensification and maintenance phases of therapy with those in a historical control group for whom antileukemia therapy ...
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Comparison between low disease activity or DAS remission as treatment target in patients with early active rheumatoid arthritis
... targeted treatment aimed at either low disease activity or remission in patients with early active rheumatoid arthritis ...with methotrexate, sulfasalazine and tapered high dose of prednisone ...
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APPEARANCE OF A METHOTREXATE BINDING PLASMA PROTEIN DURING HIGH DOSE METHOTREXATE THERAPY
... extremely high doses (8-15 gms/m 2 ) in the treatment of osteosarcoma 2 , non-Hodgkin’s lymphoma and metastatic head and neck cancer 3 ...Such high doses facilitate the passive entry of MTX in most ...
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The Administration of the Irinotecan with Oxaliplatin, Actinomycin and Methotrexate may not be Feasible for Relapsed Germ Cell Tumours with Poor Prognosis.
... The treatment of germ cell tumours is considered to be one of the major successes in the arena of cytotoxic ...actinomycin-D, methotrexate, etoposide and cisplatin) which delivered dose intense ...
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Primary Cerebral Lymphoma: About 22 Cases with Literature Review
... The treatment consists of a high dose of methotrexate based CMT associated with a consolidation by radi- otherapy on total brain; This strategy is most commonly used for the treatment ...
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