High glucose-induced damage
Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells
... factor induced in response to oxidative stress, triggers the production of various antioxidant enzymes and phase II detoxification enzymes, including haem oxygenase-1 (HO-1), quinone oxidoreductases (NQO1) and ...
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Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state
... attenuates high glucose-induced cell damage in rat retinal capillary endothelial cells (RCECs) and to explore the mechanisms ...to high concentration of glucose (30 mM) for 72 h ...
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Original Article Matrine attenuates high glucose-induced podocyte damage by inhibiting HMGB1-associated TLR4-NF-κB signaling
... renal damage, including kidney ischemia reperfusion injuries [15] and sepsis-induced kidney injuries ...renal damage in DN, as well as other renal damage, by stimulating inflammatory and ...
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The anti inflammatory and antifibrotic effects of Coreopsis tinctoria Nutt on high glucose fat diet and streptozotocin induced diabetic renal damage in rats
... low—and high-dose AC for 4 weeks, TC and triglyceride levels were significantly ...Blood glucose was only decreased in the low-dose AC group, and insulin secretion was only increased in the high-dose ...
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<p>Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway</p>
... It is worth noting that PI3K/Akt/eNOS signaling acti- vation in HUVECs was suppressed by HG-treatment. PI3K/Akt pathway may act as a positive regulator of endothelial NO synthase in endothelial cells and play a key role ...
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ALPHA LIPOIC ACID PREVENTS PANCREATIC ISLET CELLS DAMAGE AND DYSLIPIDEMIA IN STREPTOZOTOCIN-INDUCED IABETIC RATS
... severe damage to the islet cells of the pancreas and lowered the plasma glucose and glycated hemoglobin (HbA1c) ...increased high density lipoprotein- cholesterol (HDL-C) ...
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Original Article The protective effect of procyanidins on high glucose-induced oxidative damage in the rabbit lens
... MDA is an end product of polyunsaturated fatty acid lipid peroxidation, which causes peroxida- tion when the free radical attacks the biofilm [22]. MDA content reflects the degree of oxida- tive damage in the ...
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Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages
... the high glucose (HG)-induced atherosclerosis-related compli- cations in macrophages via oxidative-nitrosative stress-regulated inflammation and ...biomolecules damage, leading to aggravation ...
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HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo
... scr-sirna for 12 hours, and then cultured under high glucose (30 mM/l) for 48 hours. The morphology of normal cells was uniform and spindle-shaped, and cells treated with high glucose became ...
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Metabolic memory in mitochondrial oxidative damage triggers diabetic retinopathy
... blood glucose and the main target of attack from dia- betes ...of glucose via hexosamine pathway ...common high glucose-induced pathogenesis process - over-production of toxic ...
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Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit
... hyperglycemia suppressed autophagy in MCs along with activating NF- κ B signaling, both of which were reversed by AS-IV treatment. The possible mechanism employed by AS-IV is the inhibition of NF- κ B signaling by ...
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Leukocyte endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF kB dependent fashion
... whether high glucose–induced upregulation of adhesive molecules were critically dependent by the activation of ...mM glucose induced an increase in NF-kB DNA binding ...reduced ...
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Role of ERK5 in Diabetic Vascular Complications
... The angiogenic responses to high glucose (25mmol/L) and ERK5 siRNA transfection were assessed using an in vitro Matrigel analysis. Following appropriate treatment, HMVECs were seeded in 96-well culture ...
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The protective effect and mechanism of catalpol on high glucose induced podocyte injury
... Catalpol was purchased from Nanjing Spring & Autumn Biological Engineering Co., Ltd. (Jiangsu, China), Roswell Park Memorial Institute (RPMI) 1640 medium was pur- chased from Gibco (Gibco Company, USA), and foetal ...
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Antiobesity activity of aqueous and ethanol extracts of Enicostemma littorale in high fat diet induced obese rats
... of high dose of Enicostemma littorale in preventing the high fat diet induced body weight gain has been observed to be almost similar to the effect produced by ...
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AYURVEDIC MANAGEMENT OF DIABETIC RETINOPATHY: PRESENT SCENARIO .......
... Diabetes is a chronic, metabolic disease characterized by high levels of glucose in blood, which leads to serious damage to the heart, blood vessels, eyes, kidneys, and nerves. Diabetic retinopathy ...
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The influence of DNA concentration in the experiment of DNA damage induced by 7 Li ions and γ rays
... In Figure 6, the curve shows the DSBs/DNA at different DNA concentrations in the absence of mannitol except the concentration of 10 ng/ul since the fraction of linear form is 100% at this concentration. It is indicated ...
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HYPERLIPIDEMIA AND HYPERTENSION; CARDIOVASCULAR RISK FACTORS, VARIOUS INDUCTION METHODS AND THEIR MANAGEMENT BY ETHNOMEDICINES
... Despite of many peril factors, hyperlipidemia and hypertension have been largely associated with cardiovascular diseases. Major cardiovascular diseases are coronary heart diseases (CHD) along with cerebrovascular ...
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Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway
... under high-glucose ...reversed high-glucose induced abnormalities, including increased cell proliferation and induced expression of TGF-β1, CTGF, and collagen IV in MMCs exposed ...
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Fermented milk improves glucose metabolism in exercise-induced muscle damage in young healthy men
... been reported that some inflammatory cytokines and chemokines, such as TNF-α and interleukin-1, attenuate the activity of insulin-mediated signaling in muscle cells [28,29]. In addition, oxidative stress can also ...
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