High-mobility group
<p>Serum high mobility group box protein 1 (HMGB1) levels reflect clinical features of childhood hemophagocytic lymphohistiocytosis</p>
... HMGB1, high mobility group box protein 1; IQR, interquartile range; AST, aspartate aminotransferase; Hb, hemoglobin; ALT, alanine transaminase; LDH, lactate dehydrogenase; sFDP, serum fibrin degraded ...
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Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes
... High-mobility group box 1 (HMGB1) is a non-histone DNA-binding protein that regulates gene expression and nucleosome stabilization [19]. HMGB1 is also a cytokine that can activate monocytes and ...
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<p>Impact of high-mobility-group A2 overexpression on epithelial-mesenchymal transition in pancreatic cancer</p>
... High-mobility group AT-hook (HMGA2) changes the DNA structure as an architectural factor, thereby regulating DNA-dependent activities, including transcription, replica- tion and ...at high ...
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Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder
... Objective: It was reported that High Mobility Group Box 1 (HMGB1), also known as the nuclear transcription factor, is a late mediator of inflammation. It was thought that HMGB1 has a prominent role ...
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Molecular isoforms of high mobility group box 1 are mechanistic biomarkers for epilepsy
... The high-mobility group box 1 (HMGB1)/TLR4 axis is a key initiator of neuroinflammation following epileptogenic injuries, and its activation contributes to seizure generation in animal ...
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Structural and functional properties of linker histones and high mobility group proteins in polytene chromosomes
... Int J De, Bini ~O 177 187 (1996) 177 Structural and functional properties of linker histones and high mobility group proteins in polytene chromosomes JACEK R WISNIEWSKI' and ULRICH GROSSBACH Third Dep[.] ...
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The High Mobility Group Protein 1 Is a Coactivator of Herpes Simplex Virus ICP4 In Vitro
... ICP4 is an activator of herpes simplex virus early and late gene transcription during infection and in vitro can efficiently activate the transcription of a core promoter template containing only a TATA box and an ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... with high morbidity and mortality ...The High Mobility Group Box 1 (HMGB1) protein is an important inflammatory mediator which alters the immune system to tissue stress and ...
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High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
... High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal ...
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Bench to bedside review: High mobility group box 1 and critical illness
... High-mobility group box 1 (HMGB1) is a DNA-binding protein that also exhibits proinflammatory cytokine-like activity. HMGB1 is passively released by necrotic cells and also is actively secreted by ...
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Renal Expression and Clinical Significance of High Mobility Group Box 1 in Lupus Nephritis
... of high mobility group box 1 (HMGB1) expression in nephridial tissues of lupus nephritis ...assessment group (BILAG) ...had high renal disease activity (BILAG ...
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High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis
... High mobility group box protein 1 (HMGB1) is a highly conserved protein, ubiquitously expressed in the nucleus of all vertebrate cells. The intranuclear functions of this protein have been well ...
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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... The pathogenesis of autism spectrum disorder (ASD) likely involves genetic and environmental factors, impacting the complex neurodevelopmental and behavioral abnormalities of the disorder. Scientific research studies ...
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
... Introduction: High mobility group box 1 protein (HMGB1) is a nuclear DNA binding protein acting as a pro- inflammatory mediator following extracellular ...
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High mobility group box-1 and its clinical value in breast cancer
... understood. High mobility group box-1 (HMGB1) is a regulator of the tumorigenesis, expansion, and invasion of cancer cells and was identified relatively ...
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High mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
... High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in human cancer, but the molecular basis of HMGA1 oncogenic activity remains ...
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High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
... High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that exerts divergent biological tasks in- side and outside of ...
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Serum High Mobility Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections
... ABSTRACT Host-derived “danger-associated molecular patterns” (DAMPs) contrib- ute to innate immune responses and serve as markers of disease progression and severity for inflammatory and infectious diseases. There is ...
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High Mobility Group Box 1 and Traumatic Brain Injury
... identify High Mobility Group Box 1 (HMGB1) as a novel causative factor in the development of cerebral oedema, mediating coagulation, pre- venting secondary brain damage as well as serving as a novel ...
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The Role of High Mobility Group Box 1 in Innate Immunity
... studies. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is implicated in various aspects of the innate immune system as a damage-associated molecular pattern molecule and a ...
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