high mobility group box 1 protein
Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... The high mobility group box-1 protein (HMGB1) is an inflammatory marker which has been shown to play a role in inducing and influencing ...
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High mobility group box 1 protein, lipopolysaccharide binding protein, interleukin 6 and C reactive protein in children with community acquired infections and bacteraemia: a prospective study
... the high-mobility group box-1 protein (HMGB1) [8-12], the lipopolysaccharide-binding protein (LBP) [13-16] and the Interleukin-6 (IL-6) [17-20] may be detectable already ...
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
... Methods: Thirty-five patients with active LN were included. Renal biopsies were performed at baseline and after standard induction therapy; corticosteroids combined with immunosuppressive drugs. The biopsies were ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... Δ30 protein acted in synergy with IL-1β to enhance IL-6 release in SFs (Chapter 4, Section ...the 1 H- 15 N HSQC spectra is presented in Figure 5.36. The ∆30 protein appeared to be well folded as the ...
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Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis
... (group 1) at 8.73 ± 3.49 × 10 9 and healthy volunteer group at ...patients group and healthy volunteer group (P ...between group 1 and 2, indi- cating that WBC counts are ...
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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
... C23 and C45 are engaged in a disulfide bridge and the cysteine in position C106 is in the reduced thiol form (HMGB1 C23-C45C106h , disulfide HMGB1), HMGB1 is stabilized in a conformation in which it functions as a ...
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Inflammasomes: Pandora’s box for sepsis
... of high-mobility group box 1 protein (HMGB1), microparticles (consisting of IL-1β, NLRP3, ASC, and CASP1) binding to endothelial cells and stimulating the induction of higher ...
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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... rocytosis (37). RAGE-deficient macro- phages were shown to have a dimin- ished capacity to phagocytose, and the inhibitory effect of HMGB1 on phagocy- tosis was contributed to the C-terminal tail of the protein. ...
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Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
... For the in vitro proliferation assay, splenocyte cultures were prepared; the cells were then incubated for 72 hours in 96- well plates with final concentrations of 0.05 μg/ml, 0.5 μg/ml, and 5 μg/ml pHMGB1. Culture ...
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Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria
... Prognostic and diagnostic biomarkers of underlying pathological processes may represent promising tools to supplement clinical and laboratory assessment and im- prove triage and clinical management of SM. In this study, ...
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Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
... HMGB1 protein levels paralleled HMGB1 mRNA expression levels, and serum levels were significantly increased in the whole MS group compared to the healthy control group (P = 2 × 10 −4 ...SPMS ...
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High mobility group box protein 1 in complex with lipopolysaccharide or IL 1 promotes an increased inflammatory phenotype in synovial fibroblasts
... be mediated by simultaneous engagement of an HMGB1 receptor (RAGE or TLR4) and the partner ligand recep- tor. By blocking IL-1RI and TLR4 with the respective receptor antagonists (IL-1 receptor antagonist or ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... of 1 mL 3% thioglycollate, and cells were harvested 4 d later by peri- toneal ...After 1 h at 37°C, nonadherent cells were removed by washing with ...
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Bench to bedside review: High mobility group box 1 and critical illness
... monocytes. In activated monocytes, the transfer of HMGB1 from the nucleus to the cytoplasm is mediated by hyperacetylation of critical lysine clusters that are components of nuclear localization signals [29]. This ...
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High mobility group box-1 and its clinical value in breast cancer
... HMGB1 protein in tissues was detected using a HMGB1 immunohistochemistry kit (Beijing Bioss Biotechnology, People’s Republic of China). The protocol was performed in accordance with the manufacturer’s instructions ...
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Molecular isoforms of high mobility group box 1 are mechanistic biomarkers for epilepsy
... (4). High-mobility group box 1 (HMGB1), a prototypical member of the DAMP fam- ily, is a known mediator of sterile neuroinflammation evoked by epileptogenic injuries (4, ...nuclear ...
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The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report
... In the current study, we showed that serum HMGB1 levels were increased in patients with HCC in comparison to healthy controls, which is consistent with the report of Cheng et al. [16]. However, the serum HMGB1 level in ...
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... factor 1 (46) have been identi- fied to contribute to HMGB1 release in warm liver I/R ...HMGB1 protein significantly decreased liver I/R injury through upreg- ulation of IL-1R–associated kinase-M, a ...
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High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
... has high- lighted functions of HMGB1 in its vari- ous forms from the whole molecule to individual domains and critical amino acid residues; its immunogenic activity either alone or in complex with cofac- tors; and ...
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The Role of High Mobility Group Box 1 in Innate Immunity
... Fig. 1. Structure of HMGB1. (A) HMGB1 protein is composed of 215 amino acids in three structural domains: the A box (1--79), B box (89-- 162), and the acidic C tail ...A box ...
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