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High Mobility Group Box Proteins

Serum High Mobility Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections

Serum High Mobility Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections

... Mx proteins in the lungs of RSV- and influenza virus-infected cotton rats was defined previously as a marker of local inflammation, typically peaking on day 7 ...

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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance

Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance

... It has been previously demonstrated that HMGB1 and IL-1β act in synergy to amplify the inflammatory response and it has been postulated that this effect is mediated by the formation of a highly active pro-inflammatory ...

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Characterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection

Characterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection

... HMG proteins are one of the most evolutionarily conserved proteins in ...tone proteins which play a role in nucleosome remodeling ...HMG box. The HMGB proteins typically interact with ...

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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

... for HMGB1. HMGB1 interaction with RAGE can mediate cell proliferation, growth and migration by activating in- tracellular signals such as nuclear factor (NF)-κB and the mitogen-activated pro- tein kinase (MAPK) pathway ...

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High mobility group box-1 and its clinical value in breast cancer

High mobility group box-1 and its clinical value in breast cancer

... cell lines (Hs5787 and MDA-MB-231) than in less aggressive MCF-7 cells. Decreasing HMGB1 proteins using an antisense ribozyme approach inhibited transformation in human breast cancer cells. In contrast, increased ...

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The Role of High Mobility Group Box 1 in Innate Immunity

The Role of High Mobility Group Box 1 in Innate Immunity

... Following its discovery, several subgroups of HMG pro- teins were identified in comprehensive studies. These addi- tional members of the protein family were found to have different functions than those of nuclear HMG ...

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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein

Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein

... the proteins whose assembly results in the formation of active inflammasome complexes are up-regulated; caspase-1 and inflammasome- associated cytokines, such as IL-1β and IL-18 are produced and activated in these ...

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High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule

High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule

... The understanding of DAMP came from original work by Matzinger (12), who in 1994 suggested that the innate immune system detects and reacts to “danger” via release of host-derived me- diators, what we now call “DAMP ...

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Overexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma

Overexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma

... Total proteins from the 20 pairs of BUC and normal bladder tissues were extracted by using Total Protein Extraction Kit (ProMab Biotechnologies, ...of proteins were electrophoretically separated by 12% ...

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Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis

Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis

... HMGB1 is a multifunctional factor that is functionally influenced by its subcellular location. It mainly exists in eukaryotic chromosomes in the cell nucleus, where it acts as a DNA chaperone to bind to minor grooves of ...

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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus

Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus

... In addition to apoptosis and necrosis, a new form of cell death was described in 2004 by Brinkmann et al. (41). They showed that neutrophils can entrap mi- croorganisms by a programmed external- ization of chromatin ...

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Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)

Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)

... Wild-type rat HMGB1 was cloned, ex- pressed and purified as described previ- ously (2). For generating C45A mutant HMGB1, cysteine at position 45 in the wild-type HMGB1 clone was substituted with alanine using the ...

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High-Mobility-Group Box Nuclear Factors of Plasmodium falciparum

High-Mobility-Group Box Nuclear Factors of Plasmodium falciparum

... 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and subjected to Western blotting experiments (see Fig. 4b) after transfer onto polyvinylidene difluoride membranes (Bio-Rad). For sexual-stage ...

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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

... HMGB1 (previously also called HMG1, amphoterin and p30) is a nonhistone DNA binding protein that is abundant in the cell nucleus. Nuclear HMGB1 acts as a DNA chaperone with DNA binding and bending activities and ...

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High mobility group box 3 as an emerging biomarker in diagnosis and prognosis of hepatocellular carcinoma

High mobility group box 3 as an emerging biomarker in diagnosis and prognosis of hepatocellular carcinoma

... To evaluate the diagnostic value of serum HMGB3 levels, the current study conducted a cohort containing patients with HCC, liver cirrhosis (LC), chronic hepatitis (CH), and healthy control. One hundred twenty-seven HCC ...

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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis

... Methods: Thirty-five patients with active LN were included. Renal biopsies were performed at baseline and after standard induction therapy; corticosteroids combined with immunosuppressive drugs. The biopsies were ...

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Renal Expression and Clinical Significance of High Mobility Group Box 1 in Lupus Nephritis

Renal Expression and Clinical Significance of High Mobility Group Box 1 in Lupus Nephritis

... patients with LN. The staining was predominantly found outlining the glomerular endothelium and was also documented in the mesangium. A less pronounced HMGB1 expression was documented in vessels and tubular cells. To ...

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High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

... High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal ...

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Serum high mobility group box protein 1 (HMGB1) levels reflect clinical features of childhood hemophagocytic lymphohistiocytosis

<p>Serum high mobility group box protein 1 (HMGB1) levels reflect clinical features of childhood hemophagocytic lymphohistiocytosis</p>

... strikingly high HMGB1 levels, patient 6 had complicated mild leukoen- cephalopathy revealed by magnetic resonance imaging (MRI) and required exchange transfusion in addition to methylpred- nisolone pulse ...

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Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes

Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes

... High-mobility group box 1 (HMGB1) is a non-histone DNA-binding protein that regulates gene expression and nucleosome stabilization [19]. HMGB1 is also a cytokine that can activate monocytes ...

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