high mobility group protein-1
The High Mobility Group Protein 1 Is a Coactivator of Herpes Simplex Virus ICP4 In Vitro
... ICP4 is an activator of herpes simplex virus early and late gene transcription during infection and in vitro can efficiently activate the transcription of a core promoter template containing only a TATA box and an ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... literature. Protein NMR spectroscopy is a powerful biophysical technique that can be used to obtain physical, chemical and electronic information about proteins in ...interaction. Protein NMR has been ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... found with non-PARylated HMGB1. To determine if the increased binding of PARylated HMGB1 to apoptotic thymo- cytes is due to interaction with PS, PARylated HMGB1 was added to viable thymocytes, which do not have PS ex- ...
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Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear DNA-binding protein, proved recently to be a potent proinflammatory cytokine implicated as an important mediator ...
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High mobility group box protein 1 in complex with lipopolysaccharide or IL 1 promotes an increased inflammatory phenotype in synovial fibroblasts
... be mediated by simultaneous engagement of an HMGB1 receptor (RAGE or TLR4) and the partner ligand recep- tor. By blocking IL-1RI and TLR4 with the respective receptor antagonists (IL-1 receptor antagonist or ...
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Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
... MS group into RRMS and SPMS patients for HMGB1 comparisons among groups, or lumping non- inflammatory neurological controls and healthy controls within a unique control group ...
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High mobility group box 1 protein, lipopolysaccharide binding protein, interleukin 6 and C reactive protein in children with community acquired infections and bacteraemia: a prospective study
... control group con- sisting of healthy children, and the inclusion of children in the newborn age ...control group - to receive the agreement from parents to take intravenous blood sam- ples from healthy ...
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The high mobility group protein HMO1 functions as a linker histone in yeast
... (Roche). Protein concentration was measured using BCA Protein Assay Kit ...of protein was resolved on 12 % SDS-PAGE, and the resolved pro- teins were transferred to polyvinylidene fluoride mem- ...a ...
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High Mobility Group Box 1 expression predicts survival of patients after resection of adenocarcinoma of the ampulla of Vater
... HMGB1, a non-histone DNA-binding protein first reported in the calf thymus in 1973, is present in most mammalian cells [19, 20]. Wang et al. showed that HMGB1 was involved in inflammatory responses [21]. ...
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Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis
... Several recently studies have tried to identify sensitive diagnostic markers reflecting the severity of AA, such as bilirubin and procalcitonin levels. In a prospective study, Procalcitonin, an established marker of ...
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Potential Role for a β-Catenin Coactivator (High-Mobility Group AT–Hook 1 Protein) during the Latency-Reactivation Cycle of Bovine Herpesvirus 1
... HMGA1 has additional functions that may be important for a latent infection and are FIG 8 wt ORF2 but not the ORF2 mutants cooperate with HMGA1 to stimulate  -catenin-dependent transcription. (A) Schematic of ORF2 and ...
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Inflammasomes: Pandora’s box for sepsis
... of high-mobility group box 1 protein (HMGB1), microparticles (consisting of IL-1β, NLRP3, ASC, and CASP1) binding to endothelial cells and stimulating the induction of higher expression ...
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The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear deoxyribonucleic acid (DNA)-bind- ing protein, was recently rediscovered as a new potent pro-inflammatory ...
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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... HMGB1 can be released from the cell into the extracellular space, where it acts as a damage-associated molecular pat- tern (DAMP) or alarmin. Translocation from the nucleus to the cytoplasm oc- curs through acetylation ...
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High mobility group protein B1 is a predictor of poor survival in ovarian cancer
... This is a retrospective validation study with patients comprehensively staged according to the International Federation of Obstetricians and Gynecologists (FIGO) staging system for ovarian cancer. Full pathology review ...
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The Role of High Mobility Group Box 1 in Innate Immunity
... HMGB1 is a ubiquitous protein that has diverse roles in mediating significant pathways of inflammation in the in- tra- and extra-cellular microenvironment. With the growing studies on HMGB1 and its cytokine-like ...
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High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
... The understanding of DAMP came from original work by Matzinger (12), who in 1994 suggested that the innate immune system detects and reacts to “danger” via release of host-derived me- diators, what we now call “DAMP ...
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<p>Serum high mobility group box protein 1 (HMGB1) levels reflect clinical features of childhood hemophagocytic lymphohistiocytosis</p>
... strikingly high HMGB1 levels, patient 6 had complicated mild leukoen- cephalopathy revealed by magnetic resonance imaging (MRI) and required exchange transfusion in addition to methylpred- nisolone pulse ...
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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... ASD. In 2010, Emanuele et al. (58) firstly suggested that HMGB1 can play a role in ASD. They observed higher HMGB1 blood concentrations in a sample of young adults with ASD than in healthy age- and gender- matched ...
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
... Thirty-five patients with SLE and biopsy-proven active LN during the period of 1996 to 2008 were included in this study. All patients fulfilled the 1982 American Col- lege of Rheumatology classification criteria for SLE ...
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