high-mobility group protein B-1
Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... literature. Protein NMR spectroscopy is a powerful biophysical technique that can be used to obtain physical, chemical and electronic information about proteins in ...interaction. Protein NMR has been ...
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High mobility group box protein 1 in complex with lipopolysaccharide or IL 1 promotes an increased inflammatory phenotype in synovial fibroblasts
... IL-1 b through formation of complexes with enhanced sti- mulatory capacity [17,18], which is of interest regarding arthritis pathogenesis as both IL-1 a and IL-1 b are abun- dant ...
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Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
... The responder patients (BILAG C/D) had lower serum levels of HMGB1 at follow-up (mean of 93.7 ± 54.2 ng/ mL, median of 94.0, range of 27.9 to 181.5) versus those with persisting renal BILAG A or B (mean of 107.4 ± ...
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High mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
... binding B box domain mediates the proinflammatory effects of HMGB1, while the DNA-binding A box is an anti- inflammatory molecule that inhibits these activities mediated by full-length HMGB1 protein ...box ...
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High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis
... DNA-binding protein and was initially named for its characteristic rapid electrophoretic mobi- lity in polyacrylamide gels ...matory protein 1 (MIP1) ...MIP-1 b , thereby promoting ...
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High Mobility Group Box Protein-1 Correlates with Renal Function in Chronic Kidney Disease (CKD)
... for 1 h in blocking buffer (5% non-fat dry milk in wash ...in 1% non-fat dry milk in wash ...UK) 1:7500 dilution for 1 ...and B were mixed and added to the PVDF mem- brane and incubated ...
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The Role of High Mobility Group Box 1 in Innate Immunity
... Fig. 1. Structure of HMGB1. (A) HMGB1 protein is composed of 215 amino acids in three structural domains: the A box (1--79), B box (89-- 162), and the acidic C tail ...the B box do- ...
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Members of the high mobility group B protein family are dynamically expressed in embryonic neural stem cells
... passages 1 and 2 were dissociated as ...Millipore, 1:500) to identify neurons, with mouse anti- GFAP (Sigma, 1:1,000) to identify astrocytes, and anti-CNP (Sigma C5922 1:100) to identify ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... HMGB1 B-Box, potentiates the inhibitory effects of HMGB1 on effero- ...or B Box-His (500 ng/mL) were incubated with recom- binant PARP-1 in a poly(ADP-ribosyl)ation reaction containing NAD and ...
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<p>HMGB1/CXCL12-Mediated Immunity and Th17 Cells Might Underlie Highly Suspected Autoimmune Epilepsy in Elderly Individuals</p>
... example, B cell markers, such as chemokine (C-X-C motif) ligand (CXCL)13 and B cell activation factor (BAFF), have been shown to be elevated in antibody-associated CNS disorders, such as anti- ...
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Potential Role for a β-Catenin Coactivator (High-Mobility Group AT–Hook 1 Protein) during the Latency-Reactivation Cycle of Bovine Herpesvirus 1
... HMGA1 has additional functions that may be important for a latent infection and are FIG 8 wt ORF2 but not the ORF2 mutants cooperate with HMGA1 to stimulate  -catenin-dependent transcription. (A) Schematic of ORF2 and ...
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Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
... binding protein that is abundant in the cell ...25-kDa protein containing two positively charged DNA-binding do- mains (HMG box A and B) and a nega- tively charged ...
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Role of high mobility group box protein 1 (HMGB1) in peripheral blood from patients with multiple sclerosis
... MS group into RRMS and SPMS patients for HMGB1 comparisons among groups, or lumping non- inflammatory neurological controls and healthy controls within a unique control group ...
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Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling
... High mobility group box chromosomal protein 1 (HMGB1), a nuclear DNA-binding protein, proved recently to be a potent proinflammatory cytokine implicated as an important mediator ...
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High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis
... All experimental protocols conducted in this study were approved by the ethics committee of Arak University of Medical Sciences. Written consent was obtained from all volunteers. The study included three groups: 23 ...
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High mobility group box 1 protein, lipopolysaccharide binding protein, interleukin 6 and C reactive protein in children with community acquired infections and bacteraemia: a prospective study
... control group con- sisting of healthy children, and the inclusion of children in the newborn age ...control group - to receive the agreement from parents to take intravenous blood sam- ples from healthy ...
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The high mobility group protein HMO1 functions as a linker histone in yeast
... (Roche). Protein concentration was measured using BCA Protein Assay Kit ...of protein was resolved on 12 % SDS-PAGE, and the resolved pro- teins were transferred to polyvinylidene fluoride mem- ...a ...
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Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post cardiac arrest syndrome: a prospective observational study using high mobility group box 1 protein
... outcome group, which shows that systemic I/R after cardiac arrest may contribute to secondary brain aggravation, de- pending on the severity with increasing BBB perme- ...
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Neuroinflammatory responses in diabetic retinopathy
... using high-throughput techniques, diabetes- induced alteration of gene expression profile in Müller cells reveals that among 78 altered genes, one third are associated with inflammation [75], suggesting that ...
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High mobility group protein B1 is a predictor of poor survival in ovarian cancer
... analysis was semi-automated using Aperio ImageScope v11.2.0.780 software. The positive pixel count v9.1 algorithm settings were modified to provide accurate calling of expression levels (Iwp(high) at 140, ...
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