High Mobility Group Proteins
Structural and functional properties of linker histones and high mobility group proteins in polytene chromosomes
... Int J De, Bini ~O 177 187 (1996) 177 Structural and functional properties of linker histones and high mobility group proteins in polytene chromosomes JACEK R WISNIEWSKI' and ULRICH GROSSBACH Third Dep[.] ...
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High Mobility Group Proteins HMGD and HMGZ Interact Genetically With the Brahma Chromatin Remodeling Complex in Drosophila
... (HMGB) proteins in higher eukaryotes but their precise function has remained ...these proteins, we infer that a major function of the abundant HMGB proteins in Drosophila is to participate in ...
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The high mobility group protein HMO1 functions as a linker histone in yeast
... mammalian high mobil- ity group (HMGB1) proteins contain two HMG domains (box A and box B) followed by an acidic C-terminal ...HMGB1 proteins have been shown to induce a less stable chromatin ...
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Investigations into the interactions of the high mobility group box 1 protein and their toxicological relevance
... HMGB1 and IL-1β have been shown to act synergistically to enhance inflammation (Sha et al., 2008; Hreggvidsdottir et al., 2009; Garcia-Arnandis et al., 2010; Wähämaa et al., 2011) and it has been proposed that this ...
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Differential expression of alarmins—S100A9, IL 33, HMGB1 and HIF 1α in supraspinatus tendinopathy before and after treatment
... alarmin proteins (S100A9, high-mobility group box 1 (HMGB1) and interleukin-33 (IL-33) and hypoxia-inducible factor 1a (HIF-1a), a subunit of an oxygen sensitive transcription factor, in three ...
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Overexpression of high mobility group box 1 contributes to progressive clinicopathological features and poor prognosis of human bladder urothelial carcinoma
... Total proteins from the 20 pairs of BUC and normal bladder tissues were extracted by using Total Protein Extraction Kit (ProMab Biotechnologies, ...of proteins were electrophoretically separated by 12% ...
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Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis
... HMGB1 is a multifunctional factor that is functionally influenced by its subcellular location. It mainly exists in eukaryotic chromosomes in the cell nucleus, where it acts as a DNA chaperone to bind to minor grooves of ...
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Neuroinflammation in Autism Spectrum Disorders: the Role of High Mobility Group Box 1 Protein
... development (10). These effects can also be achieved in the absence of active infection, via generalized inflammatory response or loss of immune regulation (16). Animal models of maternal immune activation (MIA) have ...
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<p>Impact of high-mobility-group A2 overexpression on epithelial-mesenchymal transition in pancreatic cancer</p>
... To further de fi ne HMGA2 function during EMT, HMGA2 was silenced and overexpressed in human pan- creatic cancer CAPAN 1 cells, and multiple EMT-asso- ciated proteins were detected. Zeb1, a transcription factor, ...
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Recent Developments in the Role of High-Mobility Group Box 1 in Systemic Lupus Erythematosus
... of proteins such as complement factor C1q and serum amyloid P component (SAP), which are involved in opsonization and thereby phagocytosis and clearance of apoptotic cells, results in spontaneous development of ...
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Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... for HMGB1. HMGB1 interaction with RAGE can mediate cell proliferation, growth and migration by activating in- tracellular signals such as nuclear factor (NF)-κB and the mitogen-activated pro- tein kinase (MAPK) pathway ...
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The involvement of high mobility group 1 cytokine and phospholipases A2 in diabetic retinopathy
... The protein levels were detected and quantified by using western blot analysis in retinal tissues of DR and their respective control. Interestingly, similar to the results obtained in the gene expression study. We ...
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High-Mobility Group 1/2 Proteins Are Essential for Initiating Rolling-Circle-Type DNA Replication at a Parvovirus Hairpin Origin
... known proteins with these characteristics suggested that the cellular factor might be a member of the high-mobility group of small, nonhistone chromosomal proteins, which bind tightly ...
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High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
... The understanding of DAMP came from original work by Matzinger (12), who in 1994 suggested that the innate immune system detects and reacts to “danger” via release of host-derived me- diators, what we now call “DAMP ...
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The High Mobility Group Protein 1 Is a Coactivator of Herpes Simplex Virus ICP4 In Vitro
... chromosomal proteins that share a DNA-binding region known as the HMG domain (reviewed in reference ...main proteins contains only one HMG domain and binds DNA more ...1/2 proteins, through DNA ...
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High mobility group box-1 and its clinical value in breast cancer
... cell lines (Hs5787 and MDA-MB-231) than in less aggressive MCF-7 cells. Decreasing HMGB1 proteins using an antisense ribozyme approach inhibited transformation in human breast cancer cells. In contrast, increased ...
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SEPARATION OF NONHISTONE HIGH MOBILITY GROUP (HMG) FROM HUMAN LYMPHOCYTES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
... hydrophobic groups to the column and therefore the remaining silica gel hydrophilic groups ought to be recovered by an ion pairing agent. Triethylamine was selected for this purpose. Others have used TFA as eluting ...
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High-Mobility-Group Box Nuclear Factors of Plasmodium falciparum
... parasite proteins exhibit a basic extension N terminal to the HMG box domain and apparently no acidic C-terminal tail, as also ob- served for the yeast NHP6A ...HMG-D proteins, the basic extension binds in ...
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High mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
... HIPK2 rescues the HMGA1 antiapoptotic effect on p53. (A) H1299 cells were infected with dl70.3 (– in the p53 row) or Adp53 (+ in the p53 row) viruses at 60 MOI. One hour after infection, cells were transfected with ...
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Serum High Mobility Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections
... Three types of influenza viruses infect humans: types A, B, and C (1). New antigenic variants of influenza A and B viruses emerge annually, giving rise to seasonal outbreaks. However, a new and very different influenza A ...
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