Hippocampal CA1 pyramidal neurons
Original Article Neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal CA1 pyramidal neurons
... nification using a 100X objective lens (100X, NA 1.40, 488 nm laser, LSM 510) (Figure 1B, up- per panel). After the collection of images, the serial sections of each high magnification image were used for spine density ...
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Neurodegeneration After Cardiac Arrest: Cell Death Mechanisms and Methods of Neuroprotection
... The currently available evidence suggests that Purkinje cells degenerate via a Ca 2+ - mediated pathway (Yamashita et al., 2006; Brasko et al., 1995; Zhao et al., 2008). In a high-[Ca 2+ ] environment, calpains cleave a ...
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Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice
... daDREAM CA1 neurons in apical dendrites, while in basal dendrites we found a significant lower spine dens- ity in daDREAM ...of hippocampal CA1 pyramidal neurons ...in CA1 ...
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Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
... of neurons and neur- onal networks ...inhibits hippocampal pyramidal neurons [16] and in recent years, it has become ap- parent that metabolic hormones enhance GABA sig- naling in ...
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Activity-dependent decrease in contact areas between subsurface cisterns and plasma membrane of hippocampal neurons
... dissociated hippocampal cultures, every neuronal soma encountered was examined along the plasma membrane for evidence of subsurface cistern ...organotypic hippocampal slice cultures, sampling was restricted ...
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Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice
... 8 neurons from 3 mice for each group, p < ...those CA1 pyramidal neurons, we found the sEPSC amplitude in the constitutive KO group was signifi- cantly increased ...abnormal CA1 ...
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Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia
... of hippocampal CA1 neurons following transient global cerebral ischemia in ...reduced hippocampal neuronal ...healthy neurons in the hippocampal CA1 sector 7 days after ...
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Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice
... of pyramidal neurons, Tg CHRNA5/A3/B4 males were crossed with Thy1-YFP (Yellow Fluorescent Protein) heterozygous fe- males ...of CA1 pyramidal neurons was determined within a 50 × 50 μm ...
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Pharmaco-ethological and Hippocampal CA1 region neurohistological study of Sertraline effects on Single-prolonged Stress-induced Rodent model of PTSD
... of CA1 pyramidal neurons was severely impaired in all SPS-exposed ...shrunk neurons were commonly found in sertraline-treated rats, especially at the dose of 18 ...
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Acupuncture attenuates cognitive deficits and increases pyramidal neuron number in hippocampal CA1 area of vascular dementia rats
... to neurons, and the density of Nissl staining in the neuronal cytoplasm is used to evaluate neuronal damage ...in hippocampal CA1 [6,20], and permanent occlusion of the bilateral common carotid ...
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The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
... (CA1) neurons of the hippocampus are widely regarded as among the most vulnerable in the mammalian CNS to ischemia ...of pyramidal cells in CA1 hippocampal sector showed that the ...
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Amyloid precursor protein modulates β-catenin degradation
... primary neurons induces β-catenin phosphorylation at Ser 33 , Ser 37 , and Thr 41 (S33/37/T41) residues, which is a prerequisite for β- catenin ubiquitinylation and proteasomal ...of neurons with APP siRNAs ...
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Therapeutic effects of policosanol and atorvastatin against global brain ischaemia-reperfusion injury in gerbils
... of pyramidal hipoccampal neurons and increased plasma oxidative markers were ...of hippocampal CA1 neurons in gerbils with ischemia-reperfusion-induced global cerebral ischemia, but ...
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Stimulation induces gradual increases in the thickness and curvature of postsynaptic density of hippocampal CA1 neurons in slice cultures
... from hippocampal slice cultures was restricted to stratum radiatum of the CA1 region immediately next to the clustered pyramidal neuronal somas, extending ~ 100 μm ...
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The effect of Medial Septum Stimulation on Hippocampal Electrophysiology and Behaviour of Freely Moving Rats
... MS neurons while animals were running and showed that most neurons were correlated with ...MS neurons and correlation was stronger for bursting and theta modulated ...Interestingly, ...
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Morphology of Rat Hippocampal CA1 Neurons Following Modified Two and Four-Vessels Global Ischemia Models
... the hippocampal CA cells was not complete and bilateral arterial occlusion in 12 minutes enhanced the reproducibility of neuropathological ...the neurons in- creased in two-vessel occlusion model which is ...
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Structural plasticity of the hippocampus in response to estrogens in female rodents
... Dendritic spines are small, membranous protrusions from the dendrites of neurons. These structures express many different receptors on their surface and serve as the primary recipients of excitatory synaptic input ...
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Expression of one important chaperone protein, heat shock protein 27, in neurodegenerative diseases
... HSP27 has been implicated in various neurodegenera- tive diseases. For example, a highly induced expression of HSP27 has been reported in the brains of aged persons and of patients with AD, being present in proliferating ...
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Neuroprotective effects of erythropoietin on Alzheimer’s dementia model in rats
... surviving neurons in the CA1 and CA3 regions of the hippocampus were performed in 6 sections per studied group using an image analysis system (Image- Pro Express ...
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Synaptic Odyssey
... Figure 5. Ultrastructure of long-term potentiation in the young adult rat hippocampus. A, Positioning of stimulating electrodes and sample locations for serial EM sections from the control (blue) and LTP (red) sites. The ...
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