hippocampal CA3
Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
... In order to examine if the liraglutide effects on the cur- rents were due to the pre- or postsynaptic mechanisms or both, we studied the influence of liraglutide on the currents in the presence of the voltage-gated ...
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Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles
... the hippocampal dentate gyrus or CA1 cell ensembles is important for memory reactivation and to generate synthetic or false ...manipulating CA3 cell ensembles has not been reported. The CA3 area of ...
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Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses
... Using hippocampal cultures and slices from TRPM2 null mice we demonstrate that the loss of these channels selectively impairs NMDAR-dependent long-term depression (LTD) while sparing long-term ...in ...
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Multiple Kinases Involved in the Nicotinic Modulation of Gamma Oscillations in the Rat Hippocampal CA3 Area
... The suppressing effect of high concentrations of nicotine was stronger in the presence of nAChR antagonists (Wang et al., 2015), which seems to indicate an effect of nicotine on the NMDAR bypassing the nAChR. One ...
14
The modulation of acute methamphetamine on the neuronal network oscillations in rat hippocampal CA3 area.
... Gamma frequency oscillations ( γ , 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in ...
13
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies
... Figure 5 Hippocampal CA3 brain region selectively vulnerable in APP, α -syn, and α -syn/APP tg mice. Immunocytochemical analysis was performed in the hippocampal CA3 pyramidal layer. A. ...
18
The mechanisms for pattern completion and pattern separation in the hippocampus
... least recently, as it is the one that is least adapted (Deco and Rolls, 2005). The whole system operates at a rather slow timescale for the transi- tions between the attractors partly because of the time for the noise ...
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Original Article Sevoflurane exposure induces short-term impairment of hippocampal synaptic plasticity in aged rats
... function. Hippocampal synaptic plasticity is well recognized to involve in learning and memory in ...in hippocampal synaptic plasticity on aged rats is still ...on hippocampal synaptic plasticity in ...
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Coccomyxa Gloeobotrydiformis Improves Learning and Memory in Intrinsic Aging Rats
... in hippocampal CA1 and CA2/3 regions of aged ...the hippocampal CA3 was upregulated much more significantly than other regions, and there is no reasonable explanation for it based on our pre- sent ...
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Influence of slow oscillation on hippocampal activity and ripples through cortico hippocampal synaptic interactions, analyzed by a cortical CA3 CA1 network model
... the CA3-CA1-subiculum-entorhinal cortex ...of hippocampal activity modulation by the cortical slow oscillation (SO) during deep sleep and anesthesia, and correlations between ripples and UP states, support ...
19
Original Article Chronic anterior thalamic nucleus deep brain stimulation reduces gliosis and neuronal loss in hippocampal CA2 and CA3 regions of epileptic rhesus monkeys
... the CA3 region, the number of NeuN-positive cells in the DBS group was higher than that in the sham-DBS group and lower than in the con- trol group ...the CA3 region, NeuN level in the DBS group ...in ...
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Heritability of hippocampal subfield volumes using a twin and non twin siblings design
... The HCP scans used in this study are of high-resolution and –contrast with 0.7mm isotropic voxels. Figure 1 and figure S2 in the supplementary section demonstrate that the internal structure of the hippocampus can be ...
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Focal CA3 hippocampal subfield atrophy following LGI1 VGKC complex antibody limbic encephalitis
... Unlike CA3, the between-group CA1 contrast did not reach statistical significance when corrected for multiple ...in CA3 than CA1 following seizures in homo- zygous LGI1 knockout mice (Chabrol et ...2010). ...
8
Effects of dalteparin on structure of hippocampal neurons of rats in chronic stress
... Peripherally generated pro-inflammatory cytokines, can induce production of cytokines in the CNS and initiate brain neuro-inflammation (Kubera, 2010). For example, systemic LPS administration induces a pe- ripheral and ...
6
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits
... Implantation of electrodes for EEG. Animals were anesthetized with a mixture of ketamine (100 mg/kg, ACE Surgical Supply Co.) and xylazine (10 mg/kg, Sigma-Aldrich) and placed in a ste- reotactic apparatus (David Kopf ...
15
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
... hippocampal function. We have found that long-term potentiation (LTP) elicited by theta burst stimulation (TBS) was significantly impaired in hippocampal field CA1 of CD animals. This deficit might be ...
12
Pannexin 1 mediated ATP release from area CA3 drives mGlu5 dependent neuronal oscillations
... 16 We confirmed the nature of the released substance to be ATP two-fold: (i) by application of the ecto-ATPase inhibitor ARL 67156 (100 µM), which enhances the spread of intercellular Ca 2+ waves (Leybaert and Sanderson, ...
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Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study
... Interestingly, animal studies demonstrate removal or inhibition of toxic tau species in the brain improves performance on a hippocampal-dependent memory task [80, 87], suggesting the potential use of anti-tau ...
18
Interactions Between Hippocampal Areas CA3 and CA1 During Slow Wave Sleep
... in CA3 are more effective than isolated single spikes in driving CA1 ...each CA3 neuron into two parts: isolated single spikes and spikes in ...each CA3 burst as a single "spike", compared to ...
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Mechanisms of Astrocytic Calcium Wave Propagation and In Vitro Hippocampal Cell Death Are Determined By The Magnitude Of Mechanical Injury
... in hippocampal slices 24 hours following mechanical injury. Within the CA3 region of the hippocampus there is a significant increase in cell death after stretch-injury that can be attenuated by inhibiting ...
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