histone acetylation
Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
... mistargeted histone acetylation and thus aberrant activation of gene expression ...in histone modification (CREBBP and CTCF), and genes target of DNA copy number alterations ...impairing ...
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Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease
... the acetylation state of histone proteins and other promoter- bound transcription factors ...of acetylation and deacetylation plays a causative role in the generation as well as in the suppression of ...
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Differential patterns of histone acetylation in inflammatory bowel diseases
... particularly acetylation, are associated with the regulation of inflammatory gene ...mucosa. Acetylation of histone H4 was significantly elevated in the inflamed mucosa in the trinitrobenzene ...
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Epigenetic Metabolite Acetate Inhibits Class I/II Histone Deacetylases, Promotes Histone Acetylation, and Increases HIV-1 Integration in CD4+ T Cells
... via histone acetylation and leads to HIV-1 reactivation in latently infected cells (2–7, 41, 46, ...as histone acetylation to modulate HIV-1 replication, we investigated the ability of acetate ...
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Histone acetylation and the role of histone deacetylases in normal cyclic endometrium
... [65]. Histone modification changes chromatin archi- tecture and regulates gene ...Since histone acetylation is an essential post-transcription modulator, it is a basic requirement in stem cell ...
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Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
... nuclear histone acetylation level and total histone acetyltransferase (HAT) and deacetylase (HDAC) activity in ejaculated sperm and their relevance to conventional sperm ...six acetylation ...
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Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae
... linker histone function is that most organisms contain multiple linker histone-encoding ...linker histone subtypeshavebeenidentifiedin mammals,includingsevensomatic and four germ line variants (Happel ...
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Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm
... targeted histone alterations determine the epigenetic state of the ...important histone modifica- tions is attachment or removal of an acetyl group, lead- ing either to gene activation or repression ...The ...
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The rate of glycolysis quantitatively mediates specific histone acetylation sites
... protein acetylation status including intracellular pH ...inhibit histone deacetylases [28, ...defined acetylation sites is also poorly ...of histone acetyl- ation from altered glucose ...
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Histone Acetylation and Reactivation of Epstein-Barr Virus from Latency
... acetylated histone H4 ...lated histone H4 ...that histone acetylation of the chromatin around Zp occurs during Zp activation in the EBV ...
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Genome scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors
... Histone acetylation links gene regulation with metabol- ism, and aberrant acetylation is associated with cancers and metabolic ...on acetylation. Our model re- vealed that histone ...
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The Carboxyl Terminus of Rtt109 Functions in Chaperone Control of Histone Acetylation
... linker histone acetylation occurs independent of the presence of other histones, we performed the above-described assay with a substrate of calf thymus H1 (Millipore) alone for either 6 ⫻ HIS- Rtt109 – ...
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Differential patterns of histone acetylation in inflammatory bowel diseases
... on histone acety- lation could be associated with its therapeutic ...by histone 4 acetylation ...with histone acetylation [28,34] and indeed with p65 acetylation ...H4 ...
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Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids
... SCFAs, mostly butyrate, have previously been identified as potent regulators of HDACs (6), associated with various bio- logical processes, including transcriptional regulation of interleukin-8 (IL-8) and monocyte ...
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RNA Binding to CBP Stimulates Histone Acetylation and Transcription
... eRNAs modulate the acetyltransferase activity of CBP in vivo Our data demonstrate that CBP binds to RNAs transcribed close to CBP binding sites such as at the YY1 enhancer Figure 6A; rec[r] ...
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DNA methylation and histone post-translational modification stability in post-mortem brain tissue
... core histone proteins H3 and H4 are highly conserved in ...decreased histone acetylation levels of the circadian rhythm gene Period2 (Per2) in the mouse suprachiasmatic nucleus ...
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Histone H3 lysine 27 acetylation is altered in colon cancer
... Aberrant acetylation of histones has been linked to CRC patho- genesis (reviewed in ...that histone acetylation is reduced in CRC and in other tumours [22]; however, examination of specific sites ...
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Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV 1 latency
... than histone acetylation/deacetylation regulate HERV ...that histone H3 acetylation was criti- cal to the expression of HERV-W and HERV-FRD env in placental tissues, where they are known to ...
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Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
... including histone modi- fications are increasingly being linked with gene dysregula- tion and cellular responses induced by air pollutants, including ambient PM ...a histone deacety- lase inhibitor [9], ...
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Original Article Chronic pethidine treatment induces histone H3 acetylation in rat brain
... els, histone acetylation is the most studied by far. Histone acetylation changes had been observed at several addiction-related genes in the nucleus accumbens (NAc), a key reward region of the ...
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