Histone acetyltransferase (HAT)
Original Article Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro
... In the present study, we examined the acetyla- tion of histones (H3 and H4) during high glucose induced EMT of human peritoneal mesothelial cells (HPMCs). Then, chromatin immunoprecipitation followed by qPCR (CHIP- qPCR) ...
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Plasmodium falciparum Histone Acetyltransferase, a Yeast GCN5 Homologue Involved in Chromatin Remodeling
... a histone acetyltransferase (HAT), is part of large multimeric complexes that are required for chromatin remodeling and transcriptional ...the HAT domain and the ...conserved HAT ...
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Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
... nuclear histone acetylation level and total histone acetyltransferase (HAT) and deacetylase (HDAC) activity in ejaculated sperm and their relevance to conventional sperm ...of HAT/HDAC1 ...
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Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae
... ABSTRACT Histone post-translational modifications (PTMs) alter chromatin structure by promoting the interaction of chromatin- modifying complexes with ...of histone PTMs. In Saccharomyces cerevisiae , the ...
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3D QSAR and docking studies on benzoylsulfonohydrazides as histone acetyltransferase KAT6A inhibitors
... of histone acetyltransferase (HAT) which are p300, GNAT (Gcn5-related N-acetyltransferase), and MYST (MOZ, Ybf2, Sas2, and Tip60 as founding members) (Voss and Thomas, ...(MOZ HAT) is ...
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HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity
... cellular histone acetyltransferase (HAT) enzymes p300 and GCN5, at residues K264, K266, and K273; this acetylation enhances DNA binding, enzyme activity, and integration (18, ...the histone ...
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Cryptococcus neoformans Histone Acetyltransferase Gcn5 Regulates Fungal Adaptation to the Host
... conserved histone acetyltrans- ferase complexes may differ according to the environmental niche, but the overall importance of gene regulation by histone acetylation is maintained in very divergent ...with ...
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No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer
... Pathogenic mutations in BRCA1 and BRCA2 account for the majority of but not all multiple-case breast cancer fami- lies that include members with ovarian cancer or male breast cancer. Among families with four or more ...
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The Histone Acetyltransferase CLOCK Is an Essential Component of the Herpes Simplex Virus 1 Transcriptome That Includes TFIID, ICP4, ICP27, and ICP22
... The impetus for the initiation of the studies reported here is the observation that ICP0 interacts with BMAL1 (19), a part- ner and regulator of the circadian histone acetyltransferase CLOCK (8, 15). Both ...
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The histone acetyltransferase inhibitor Nir regulates epidermis development
... that histone acetylation can be present at some genes together with putative repressive histone marks (De Gobbi et ...the histone acetyltransferase p300 and the HDAC SIRT1, increases Foxp3 ...
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Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis
... The histone acetyltransferase activity provided by NuA4 is required for the presetting of the inducible PHO5 promoter during the transition from a transcrip- tionally inactive to an active state in the ...
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Dissecting The Molecular Basis Of The Scaffold Protein Jade In Hbo1 Histone Acetyltransferase (hat) Activity
... HBO1 HAT complex on the histones and the HHBD orients the HAT domain by acting as a bridge between the HAT domain and the ...the histone core (Figure ...
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An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in C. elegans males
... of histone acetyltransferases ...different histone acetyltransferases (HATs), MYS-1, MYS-2, MYS-4 and ...fly HAT respon- sible for H4K16ac on the male ...family histone acetyltransferases ...
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Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis
... acetylated histone 3; ARE: antioxidant response element; DMM: destabilization of the medial meniscus; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; HAT: histone acetyltransferase; HDAC: ...
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Structure of noncoding RNA is a determinant of function of RNA binding proteins in transcriptional regulation
... The majority of the noncoding regions of mammalian genomes have been found to be transcribed to generate noncoding RNAs (ncRNAs), resulting in intense interest in their biological roles. During the past decade, numerous ...
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The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration
... hGFAP-cre::CBP Fl/Fl OB, cells from the V-SVZ tissue ex- plant of either control or hGFAP-cre::CBP Fl/Fl mice ex- hibited a significantly reduced number of single cells surrounding the t[r] ...
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The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16
... the histone acetyltransferase (HAT) p300 and repress HER2 in the HER2-overexpressing human breast cancer cell line ...for histone modification to repress transcription in human cancer ...
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Kruppel like factor 15 is critical for vascular inflammation
... Activation of cells intrinsic to the vessel wall is central to the initiation and progression of vascular inflam- mation. As the dominant cellular constituent of the vessel wall, vascular smooth muscle cells (VSMCs) and ...
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The Pygo2 H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling dependent transcription
... of histone H3 ...of histone binding for the role of Pygo2 as a Wnt signaling component and as a reader of chromatin modifications remains ...the histone acetyltransferase Gcn5 to chromatin, ...
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Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection
... Specific HAT inhibitors were able to postpone pupation and to reduce insect survival following wounding, whereas HDAC inhibitors accelerated pupation and increased ...induced HAT activity, suggesting that ...
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