Histone deacetylases
Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate resistant prostate cancer cells
... Histone deacetylases (HDACs) are a family of enzymes associated with cancer risk. Post-translational modification of histones, in particular the removal or addition of acetyl groups on ε-N-acetyl lysine ...
15
Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications
... Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, studies over the past decades have demonstrated that epigenetic regulation also participates in the development of cancer. The ...
14
Class IIa histone deacetylases: conducting development and differentiation
... In addition to their similar structural organization, class IIa HDACs also share the same overall mechanism of regulation. Regulation of class IIa members relies on their ability to shuttle between the nucleus and the ...
12
Histone Deacetylases and the Nuclear Receptor Corepressor Regulate Lytic-Latent Switch Gene 50 in Murine Gammaherpesvirus 68-Infected Macrophages
... Gammaherpesviruses are important oncogenic pathogens that transit between lytic and latent life cycles. Silencing the lytic gene expression program enables the establishment of latency and a lifelong chronic infection of ...
9
Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation
... multiple histone deacetylases with antagonistic functions at HMR and HML and Sir2’s catalytic function in the nucleation of the Sir proteins at the ...
31
Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer
... Bladder cancer is one of the most common malignancies and causes hundreds of thousands of deaths worldwide each year. Bladder cancer is strongly associated with exposure to environmental carcinogens. It is believed that ...
11
The yeast Cyc8 Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene
... promoter histone deacetylation has been proposed to enhance further binding of Cyc8 – Tup1 thereby reinforcing transcription repression of target genes ...the histone deacetylases Hda1p and Rpd3p ...
14
Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
... Abstract: Histone deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other ...of histone deacetylase ...
14
Expression of class I histone deacetylases during chick and mouse development
... ABSTRACT Histone deacetylases (HDACs) are a family of enzymes which regulate the acetylation state of nucleosomal histones, as well as non-histone ...
12
Inhibition of Histone Deacetylases Induces Bovine Leukemia Virus Expression In Vitro and In Vivo
... of histone deacetylases, acetylation being a major characteristic of transcriptionally active ...of deacetylases, trichostatin A (TSA) and trapoxin ...
9
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
... as histone and DNA modifications, play a crucial role in these ...by histone acetyltrans- ferases (HATs) and histone deacetylases (HDACs), which are “classically” considered as transcriptional ...
19
Histone deacetylases 1 and 2 are required for brain development
... - histone acetyltransferases (HATs) and histone deacetylases (HDACs) establish and maintain specific patterns of histone acetylation in balance, thereby contributing to both transcriptional ...
8
Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells
... Histone deacetylases (HDACs) play crucial roles in the initiation and progression of cancer, offering a promising target for cancer ...restored histone acetylation, suppressed cell growth and induced ...
14
Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles
... modifiers. Histone deacetylases (HDACs) are an evolutionarily conserved group of enzymes that remove acetyl groups from histones as well as nonhistone proteins ...
11
Multiple stage dependent roles for histone deacetylases during amphibian embryogenesis: implications for the involvement of extracellular matrix remodeling
... Fig. 2. Blocking histone deacetylases leads to stage-dependent developmen- tal defects. TSA was added to embryo or tadpole-rearing water at a concentration of 100 nM at various developmental stages as ...
8
Histone Deacetylases 1 and 2 Are Phosphorylated at Novel Sites during Varicella-Zoster Virus Infection
... of histone deacetylases (HDACs) (7, 20, 23, ...on histone tails, resulting in chromatin condensation and re- pression of gene expression ...of histone acetyltransferases, HDACs and ...
12
A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression
... around histone octam- ers ...including histone acetyltrans- ferases and histone deacetylases (HDACs) (reviewed in refer- ence ...in histone tails by histone acetyltransferases ...
8
A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages
... Gammaherpesviruses and histone deacetylases. HDAC1 and -2 are classically considered to repress transcription and are thus targeted by several alpha- and betaherpesvirus proteins (9, 10, 14, 15, 48, 49). ...
13
Original Article Histone deacetylases 3 (HDAC3) is highly expressed in cervical cancer and inhibited by siRNA
... Cervical carcinoma is one of the most widely female genital neoplasms and occupies lead- ing causes of female deaths in developing country. Cervical carcinoma is characterized as substantial morbidity, easily metastasis ...
6
Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L
... Lack of absolute selectivity against cancer cells is a major limitation for current cancer therapies. In the previous study, we developed a prodrug strategy for selective cancer therapy using a masked cytotoxic agent ...
9