Histone deacetylases (HDACs)
Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate resistant prostate cancer cells
... Histone deacetylases (HDACs) are a family of enzymes associated with cancer risk. Post-translational modification of histones, in particular the removal or addition of acetyl groups on ε-N-acetyl lysine ...
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Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
... Abstract: Histone deacetylases (HDACs) are key regulators of gene expression in cells and have been investigated as important therapeutic targets for cancer and other ...of histone deacetylase ...
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Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy
... regulators: histone acetyltransferases (HATs) and histone deacetylases ...altering histone acetylation to modify chromatin structure, and by regulating the activity of non-histone ...
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The yeast Cyc8 Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene
... promoter histone deacetylation has been proposed to enhance further binding of Cyc8 – Tup1 thereby reinforcing transcription repression of target genes ...the histone deacetylases Hda1p and Rpd3p ...
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Histone Deacetylases 1 and 2 Are Phosphorylated at Novel Sites during Varicella-Zoster Virus Infection
... of histone deacetylases (HDACs) (7, 20, 23, ...on histone tails, resulting in chromatin condensation and re- pression of gene expression ...of histone acetyltransferases, HDACs and ...
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Histone deacetylases 1 and 2 are required for brain development
... - histone acetyltransferases (HATs) and histone deacetylases (HDACs) establish and maintain specific patterns of histone acetylation in balance, thereby contributing to both transcriptional ...
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Class IIa histone deacetylases: conducting development and differentiation
... mal histones in the vicinity of target promoters. Since class IIa HDACs do not bind to DNA, their repressive activity relies on interactions with sequence-specific DNA binding proteins, which thus dictate the targeting ...
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Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells
... Histone deacetylases (HDACs) play crucial roles in the initiation and progression of cancer, offering a promising target for cancer ...restored histone acetylation, suppressed cell growth and induced ...
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Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer
... Bladder cancer is one of the most common malignancies and causes hundreds of thousands of deaths worldwide each year. Bladder cancer is strongly associated with exposure to environmental carcinogens. It is believed that ...
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Expression of class I histone deacetylases during chick and mouse development
... ABSTRACT Histone deacetylases (HDACs) are a family of enzymes which regulate the acetylation state of nucleosomal histones, as well as non-histone ...
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Role of Histone Deacetylases in Fungal Phytopathogenesis: A Review
... of histone deacetylases in fungus and their secondary metabolism, growth and pathogenesis is essential for unlocking the mechanisms for synthesis of novel, natural product chemicals from ...
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A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression
... around histone octam- ers ...including histone acetyltrans- ferases and histone deacetylases (HDACs) (reviewed in refer- ence ...in histone tails by histone acetyltransferases ...
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A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages
... Gammaherpesviruses and histone deacetylases. HDAC1 and -2 are classically considered to repress transcription and are thus targeted by several alpha- and betaherpesvirus proteins (9, 10, 14, 15, 48, 49). ...
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Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications
... Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, studies over the past decades have demonstrated that epigenetic regulation also participates in the development of cancer. The ...
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Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
... as histone and DNA modifications, play a crucial role in these ...by histone acetyltrans- ferases (HATs) and histone deacetylases (HDACs), which are “classically” considered as transcriptional ...
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Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L
... Lack of absolute selectivity against cancer cells is a major limitation for current cancer therapies. In the previous study, we developed a prodrug strategy for selective cancer therapy using a masked cytotoxic agent ...
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Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles
... modifiers. Histone deacetylases (HDACs) are an evolutionarily conserved group of enzymes that remove acetyl groups from histones as well as nonhistone proteins ...
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Original Article Histone deacetylases 3 (HDAC3) is highly expressed in cervical cancer and inhibited by siRNA
... Cervical carcinoma is one of the most widely female genital neoplasms and occupies lead- ing causes of female deaths in developing country. Cervical carcinoma is characterized as substantial morbidity, easily metastasis ...
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Histone Deacetylases and the Nuclear Receptor Corepressor Regulate Lytic-Latent Switch Gene 50 in Murine Gammaherpesvirus 68-Infected Macrophages
... Gammaherpesviruses are important oncogenic pathogens that transit between lytic and latent life cycles. Silencing the lytic gene expression program enables the establishment of latency and a lifelong chronic infection of ...
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Activation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) by Inhibitors of Class III Histone Deacetylases: Identification of Sirtuin 1 as a Regulator of the KSHV Life Cycle
... II histone deacetylases (HDACs) potently reactivate KSHV from la- tency, the role of class III HDAC sirtuins (SIRTs) in KSHV latency remains ...active histone H3 trimethyl Lys4 (H3K4me3) mark but ...
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