Histone H2AX
Low level phosphorylation of histone H2AX on serine 139 (γH2AX) is not associated with DNA double-strand breaks
... The most conspicuous case of “dim” γH2AX foci is presented by exposure to CPT. Here the “dim” γH2AX foci were numerous but exhibited neither proximity to replication sites nor to 53BP1 foci (Figure 6D, 6H, Supplementary ...
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Original Article MiR-328 targets histone H2AX and regulates lung cancer cells apoptosis
... that histone H2AX is a downstream target of miR-328, which can bind directly to the 3’-untranslated region (3’-UTR) of H2AX, subsequently downregulating both the mRNA and protein levels of ...of ...
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Original Article Phospho-histone H2AX is a diagnostic and prognostic marker for epithelial ovarian cancer
... Abstract: Background: Histone H2AX phosphorylation is a sensitive marker for DSB which contributes to both ge- nomic instability and cancer treatment. Monitoring its formation may be a sensitive means to ...
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Widespread Phosphorylation of Histone H2AX by Species C Adenovirus Infection Requires Viral DNA Replication
... than H2AX (data not ...phosphorylated H2AX appeared prior to complete Mre11 degradation, these results demonstrate that ...Phosphorylated H2AX accumulates at late times after in- fection with ...
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Gadd45b deficiency promotes premature senescence and skin aging
... phospho- histone H2AX (γH2AX) stained cells compared with their wild type counterparts (Figure 8A and 8B) indicating that Gadd45b deficiency leads to increased DNA double-strand breaks in the skin in ...
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In vivo Analysis of H2AX Phosphorylation Induced by γ-Radiation
... as histone H2AX are potential candidates in the early stages of response to ionizing radiation, specifically to ...DSB. Histone H2AX is a H2A histone derivative with molecular weight of ...
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MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA
... Histone H2AX is a tumor suppressor protein that plays an important role in ...of H2AX with apoptosis in cancer cells remains ...that H2AX knockdown in lung cancer A549 cells affected the ...
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Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells
... the histone H2AX than their non-transfected counterparts. Higher H2AX expression may be involved in ...to H2AX–GFP expression by looking for distinct types of mammary cells that express these ...
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H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication
... A number of viruses including HSV induce the host DNA damage response pathway and subsequent phos- phorylation of histone H2AX [6, 7]. However, the mech- anism that triggers this pathway and its importance ...
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H2AX Phosphorylation Is Important for LANA-Mediated Kaposi's Sarcoma-Associated Herpesvirus Episome Persistence
... with H2AX through its amino- and carboxy- terminal ...of H2AX/␥H2AX with LANA by coimmunoprecipitation and GST pulldown ...␥ H2AX in KSHV-positive cells. These results demonstrated that ...
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LIA4 Encodes a Chromoshadow Domain Protein Required for Genomewide DNA Rearrangements in Tetrahymena thermophila
... phosphorylated histone H2AX (␥H2AX) in the developing macronucleus has been re- ported ...conserved histone vari- ant occurs in response to DNA damage, the authors hypothesized that the ␥ ...
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Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes
... [43]. Histone modifiers also control the differentiation of MSCs into mesoderm cell ...of histone acetylation on the promoter regions of the early cardiomyocyte-specific genes GATA4 and ...(a histone ...
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Establishment of Murine Cytomegalovirus Latency In Vivo Is Associated with Changes in Histone Modifications and Recruitment of Transcriptional Repressors to the Major Immediate-Early Promoter
... against histone H3, histone H4, acetylated histone H3 (Ac-H3), or acetylated histone H4 (Ac-H4), followed by quantitative real-time PCR with primers/probe specific to  -actin (top panels), ...
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Histone deacetylase modulators provided by Mother Nature
... proteasome. Histone acetyl transferases (HATs) and his- tone deacetylases (HDACs) regulate the balance of lysine acetylation on histones and non-histone proteins ...
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MOLECULAR DOCKING STUDY, SYNTHESIS AND INVITRO EVALUATION OF ANTITUMOR ACTIVITY OF NOVEL NAPHTHYLIDENE BASE OF BENZOIC ACID DERIVATIVES
... of histone has two forms as Histone acetylases and Histone deacetylases 1 HDACs are involved in cell-cycle progression and differentiation, and their deregulation is associated with several cancers 2 ...
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Constitutive heterochromatin formation and transcription in mammals
... distinct histone lysine methylation systems reveals a surprising plasticity in propagating methylation patterns in chromatin and offers important insights into fundamental biological ...
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Histone Lysine Methylation: A Potential New Treatment Target with Respect to BDNF Gene in Type 2 Diabetic Retinopathy
... environment. Histone lysine methylatio take part in alteration of chromatin structure and regulation of gene ...into histone modification may provide the mode for therapeutic function of drugs in ...on ...
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DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing
... γ H2AX and 53BP1 foci numbers only in the G1 (EdU- negative) ...that H2AX plays a critical role in iPSC ...γ H2AX during the cellular reprogramming of mouse embryonic fibro- blasts independent of ...
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Novel insights into epigenetic drivers of oropharyngeal squamous cell carcinoma: role of HPV and lifestyle factors
... Besides genetic alterations, the accumulation of aberrant epigenetic events deeply influence OPSCC biology and may contribute, at least in part, to the differences between HPV-driven and non-HPV-driven OPSCC [11]. To ...
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γ-H2AX expression detected by immunohistochemistry correlates with prognosis in early operable non-small cell lung cancer
... Results: Sixty-three patients (65.2%) died during the follow-up period. The mean survival time was 32.2 ± 1.9 months (95% confidence interval [CI]: 28.5–35.8 months; median 30.0 months); 1-, 2- and 3-year survival rates ...
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