Histone H3 lysine 27
Regulation of Phytohormone Biosynthesis Genes by Polycomb-Mediated Histone H3 Lysine 27 Trimethylation in Arabidopsis
... Abstract: Histone H3 lysine 27 trimethylation (H3K27me3) catalyzed by polycomb proteins plays a negative role in the regulation of gene ...
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The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation
... of histone demethylase in tumourigen- esis still remains unclear, especially with regards to ...inhibitory histone modifications determines gene ...of histone H3 lysine 27 ...
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CBP mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing
... of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2 (PRC2) is essential for transcriptional silencing of Polycomb target genes, whereas acetylation of H3K27 (H3K27ac) has ...
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Cytosolic acetyl-CoA promotes histone H3 lysine 27 acetylation in Arabidopsis
... a plant homeodomain (PHD) finger that is considered to be an H3K4me3 reader (Li et al., 2006). The TAZ-type of zinc finger domain presented in CBP/p300 family participates in the protein-protein interactions with ...
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Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2
... total H3 levels remain unchanged in both cell pop- ...total histone H3; (C) total acetylated histone H3; (D) EZH2; (E) H3K27me3; (F) ...
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Histone H3 lysine 27 acetylation is altered in colon cancer
... H3K27Ac was first discovered in yeast [27] and is present in animals and plants [28]. Recent advancements in DNA sequencing technology have enabled the ana- lysis of histone modification distribution ...
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Long noncoding RNAs, emerging players in muscle differentiation and disease
... acetylated histone H3 lysine 27; H3K4me1: monomethyl histone H3 lysine 4; IMP: Igf2 mRNA binding-protein; iPSC: induced pluripotent stem cell; IRES: internal ribosomal ...
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Targeting FBPase is an emerging novel approach for cancer therapy
... [22]. Lysine (K)-specificdemethylase 1A (LSD1)- mediated demethylation of H3K4me2 at FBP1 promoters suppressed FBP1 expression in HepG2 cells ...of histone deacetylase inhibitor further increased FBPase ...
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Establishment of Murine Cytomegalovirus Latency In Vivo Is Associated with Changes in Histone Modifications and Recruitment of Transcriptional Repressors to the Major Immediate-Early Promoter
... of histone modifications change when latency is ...histones H3 and H4 bound to the MIEP are acetylated at lysine residues associated with active transcription and H3 is methylated at ...
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Epigenetic regulation of caloric restriction in aging
... H2B, H3 and H4 mono- mers) [69]. In most cases, histone remodeling occurs at the N-terminal group of lysine (K) residues in histones by diverse modification patterns such as acetylation, methylation, ...
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Methylation of Histone H3 Lysine 36 Is Required for Normal Development in Neurospora crassa
... influencing histone-DNA, histone-histone, and histone-non- histone protein interactions (16, ...of histone modifications constitute a “histone code” that can impact chro- ...
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Characterization of the grappa Gene, the Drosophila Histone H3 Lysine 79 Methyltransferase
... Like K4, little if any H3 mono- or dimethyl K79 could be detected in early nuclear cleavage stage embryos. However unlike K4, K79 methylation does not appear to be activated when transcription commences in ...
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Histone H3 lysine K4 methylation and its role in learning and memory
... liquid chromatography–tandem MS (LC–MS/MS). Ana- lyzed peptides can then be mapped back to the protein by comparing the obtained tandem mass spectra with theoretical tandem mass spectra generated from in silico digestion ...
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Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b
... other H3 PTM analyzed ...other H3 PTMs following vitamin C treatment (Additional file 1: Figure ...to histone demethylases, and/ or because it is a transient step on the way to ...
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Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma
... Disruptor of telomeric silencing 1-like (Dot1l), located on the nucleosome surface, is the only known mammalian histone methyltransferase which targets the H3K79 position [10]. Just like its homolog gene Dot1 ...
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Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
... Over the past 15 years, it has been contentious whether H3K9 methylation is enriched on the mouse inactive X, and even in species where H3K9 methylation has been accepted to accumulate on the Xi, its role has remained ...
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The influence of DNA sequence on epigenome-induced pathologies
... as we try to address epigenome-induced pathologies. First, we are in a better technical position than ever before to determine the influence of genotype on epitype. New rapid DNA sequencing and DNA bead array methods for ...
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Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila
... “activating” histone PTMs and de- pleted in “repressing” histone PTMs (McKittrick et ...the histone PTMs enriched on H3.3 relative to H3 is acetylation of lysine nine (K9ac), a mark ...
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Lysine specific demethylase 1 mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
... against histone H3, mono-, di- and tri- methylated H3K9, as well as mono-, di- and trimethylated H3K4, were purchased from EMD Millipore (Billerica, MA, ...
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Histone H3 Lysine 4 Methylation Marks Postreplicative Human Cytomegalovirus Chromatin
... the H3 core domain (total H3; ab1791; Abcam) and H3K9/ 14ac (06-599 [Merck Millipore] or H5110-13A1 [United States Biologi- cal]), H3K9me2 (07-441; Merck Millipore), or H3K4me2 (07-030; Merck ...
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