Histone methyltransferases
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
... bearing EZH2-activating mutations [120]. In April 2014, GlaxoSmithKline began a phase1/2 dose escalation study to investigate the safety, pharmacokinetics, pharmaco- dynamics, and clinical activity of GSK2816126 (GSK126) ...
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Nicetto, Dario (2012): On the way to differentiation: xenopus Suv4-20h histone methyltransferases regulate the transition from the pluripotent to the ectoderm cell state. Dissertation, LMU München: Fakultät für Biologie
... of histone modifcations and DNA methylation (Surani, Hayashi et ...involving histone methyltransferases, transcription repressors, miRNA, and DNA methylation, creating an “epigenetic enviroment” ...
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Elucidation of the Two H3K36me3 Histone Methyltransferases Set2 and Ash1 in Fusarium fujikuroi Unravels Their Different Chromosomal Targets and a Major Impact of Ash1 on Genome Stability
... H3K36 histone methyltransferases Set2 and Ash1 in the filamentous ascomycete Fusarium ...H3K36 methyltransferases in higher ...H3K36-specific histone methyltransferases that deposit ...
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Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
... repressive histone methylation signatures (10, 18, 40, 44, ...contains histone H3K9 demethylases (LSD1, JMJD2s) and histone H3K4 methyltransferases (SETD1A, MLLs), which limits the ...
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Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers
... recombinant histone octamers as the ...for histone H3 ...H3K4me3 histone tail ...dimethylated histone tail mimics were used, and the lowest incorporation of the methyl donor group was detected ...
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Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans
... of histone peptides was achieved using a gradient of 0–26% buffer B over 45 min; then the column was washed by running from 26 to 80% buffer B over 5 min followed by isocratic 80% buffer B for 10 ...
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Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma
... Euchromatic histone-lysine N-meth- yltransferase 1 and 2 (EHMT1/2, also known as GLP and G9A, respectively) are epigenetic enzymes that pro- mote transcriptional repression through histone modifi- cations ...
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Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV 1 Latency
... H3K27 histone lysine methyltransferase (HKMT) component of Polycomb repressive complex 2 (PRC2), plays a critical role in controlling HIV latency in Jurkat T-cell models of latency (23, ...additional ...
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The role of H3K4 methyltransferases in Drosophila memory
... that histone methyltransferase activity results in memory phenotypes, immunohistochemistry on adult MB nuclei can be done to broadly quantify levels of H3K4me1 and H3K4me3 in response to genetic ...of ...
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DNA methyltransferases and their roles in tumorigenesis
... and/or histone modification, thus resulting in chromatin remodeling, genomic instability and gene ...as histone methyltransferases and transcriptional co-suppressors, is highly important in ...
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Histone H3 lysine 4 methyltransferases and demethylases in self-renewal anddifferentiation of stem cells
... specific histone methyltransferases, including LSD1 inhibitors, have been developed by several pharmaceutical compan- ies, although their specificities and efficacies require im- provement ...of ...
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Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm
... Results: A comparative study of AAA tissue samples ( n = 37, open surgical intervention) and healthy aortae ( n = 12, trauma surgery) was performed using quantitative PCR, immunohistochemistry (IHC), and Western blot. ...
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Histone H4 Facilitates the Proteolysis of the Budding Yeast CENP-ACse4 Centromeric Histone Variant
... eliminate histone mutants that are defective in galactose metabolism, positive hits were rescreened to compare their growth on galactose with a control vector [YEplac181 (Gietz and Sugino 1988)] with that of the ...
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A tale of histone modifications
... The essential yeast Esa1 acetyltransferase is a MYST family member that predominantly modifies histones H4 and H2A within the native NuA4 HAT complex [20]. Esa1 and Gcn5 both contribute to the regulation of the PHO5 gene ...
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The Effect of 5-Aza-2′-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apop
... 8. Herold C, Ganslmayer M, Ocker M, et al. The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol. 2002; 36(2):233-40. 9. Sanaei M, ...
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Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae
... To further investigate the role of histone acetylation in regulating Hho1 binding, we performed ChIP-seq analysis of Hho1 expressed from its native promoter. To visualize the data generated, we used 2D occupancy ...
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Lineage Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone
... 17. Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev S, Dryden DT, Dybvig K, Firman K, Gro- mova ES, Gumport RI, Halford SE, Hattman S, Heitman J, Hornby DP, Janulaitis A, ...
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Linker Histone in Diseases
... The linker histone also plays an important part in the process of spermatogenesis. Mammal sperms are characterized with highly condensed nuclei, and to achieve such high condensation, linker histones go over ...
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Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus.
... The column fractions from the uninfected A or infected B cell extracts were assayed for methyltransferase activity in the presence of2 mM each of GTP and Mg2+, using either unmethylated [r] ...
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Phytophthora methylomes are modulated by 6mA methyltransferases and associated with adaptive genome regions
... Results: We show that the oomycetes Phytophthora infestans and Phytophthora sojae possess functional adenine N6-methylation (6mA) methyltransferases that modulate patterns of 6mA marks across the genome. In ...
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